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| 1 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | Airway and alveolar nitric oxide measurements in obstructive sleep apnea syndrome 显示文摘 | Fortuna AM Miralda R Calaf N | 2011 | Respir Med2011，105，： | 1 |
| 3 | Instability of short tandem repeats (microsatellites) in human cancer显示文摘 | Wooster R Cleton-Jansen AM Collins N | 1994 | Nat Genet1994，6，： | 1 |
| 4 | Airway and alveolar nitric oxide measurements in obstructive sleep apnea syndrome 显示文摘 | Fortuna AM Miralda R Calaf N | 2011 | Respir Med2011，105，4： | 1 |
| 5 | L - arginine supplementation in peripheral arterial disease: no benefit and possible harm 显示文摘 | Wilson AM Harada R Nair N | 2007 | Circulation2007，116，2： | 1 |
| 6 | Helico- bacter pylori induces RANTES through activation of NF κB 显示文摘 | MORI N KRENSKY AM GELEZIUMAS R | 2003 | Infect Immun2003，71，7： | 1 |
| 7 | Medical meth- ods for first trimester abortion 显示文摘 | Kulier R Kapp N Giilmezoglu AM | 2011 | Cochrane Database Syst Rev2011，11，21： | 1 |
| 8 | Mycorrhiza development in onion in response to inoculation with chitin-decomposing actinomycetes显示文摘 | AMES N R | 1989 | New Phytologist1989，112，3： | 1 |
| 9 | Investigation of local ACEactivity and structural alterations during development of L-NAME-induced hypertension显示文摘 | Sharifi AM Akbarloo N Darabi R | 2005 | Pharmacol Res2005，52，5： | 1 |
| 10 | Hyphal uptake and transport of nitrogen from two 15 N-labelled sources by Glomus mosseae, a vesicular- arbuscular mycorrhizal fungus显示文摘 | Ames R N Reid C P P Porter L K | 1983 | New Phytologist1983，95，3： | 1 |
| 11 | A phase Ⅰ clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors显示文摘 | Scott AM Tebbutt N Herbertson R | 2007 | Proc Natl Acad Sci2007，104，： | 1 |
| 12 | Hyphal uptake and transport of nitrogen from two ^15N-labelled sources by Glomus mosseae (a vesicular-arbuseular mycorrhizal fungus) 显示文摘 | Ames R N Reid C P P Porter L K | 1983 | New Phytol1983，95，： | 1 |
| 13 | Nestin expression in reactive astrocytes following focal cerebral ischemia in rat显示文摘 | Duggal N Schmidt-kastner R Hakim AM | 1997 | Brain Res1997，768，12： | 1 |
| 14 | Development of a laboratory - scale flaking machine for oat end products testing 显示文摘 | Ames N P Rhymer C R | 2003 | Cereal Chemistry2003，80，6： | 1 |
| 15 | Instability of short tandem repeats (microsatellites) in human cancers显示文摘 | Wooster R Cleton Jansen AM Collins N | | 0，，： | 1 |
| 16 | TNFalpha modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts显示文摘 | Connor AM Mahomed N Gandhi R | 2012 | Arthritis Res Ther2012，14，2： | 1 |
| 17 | Identifying blood biomarkers and physiological processes that distinguish humans with superior performance under psychological stress显示文摘 | Cooksey AM Momen N Stocker R | | 0，，12： | 1 |
| 18 | Endogenous oxidative damage of deoxycytidine in DNA 显示文摘 | Wagner J R Hu C C Ames B N | 1992 | Proceedings of the National Academy of Sciences1992，89，8： | 1 |
| 19 | Detection of pieomole levels of hydroperoxides using a fluorescent dichlorofluoreseein assay显示文摘 | Cathcart R Schwiers E Ames B N | 1983 | An- alytical Biochemistry1983，34，1： | 1 |
| 20 | Effects of skim milk pow- der enriched with glycomacropeptide and G600 milk fat extract on frequency of gout flares : a proof- of-concept randomised controlled trial显示文摘 | Dalheth N Ames R Gamble GD | 2012 | Ann Rheum Dis2012，71，6： | 1 |
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