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| 1 | Metabolomic and elemental profiling of blood serum in bladder cancer显示文摘Bladder cancer(BC)is one of the most frequently diagnosed types of urinary cancer.Despite advances in treatment methods,no specific biomarkers are currently in use.Targeted and untargeted profiling of metabolites and elements of human blood serum from 100 BC patients and the same number of normal controls(NCs),with external validation,was attempted using three analytical methods,i.e.,nuclear magnetic resonance,gold and silver-109 nanoparticle-based laser desorption/ionization mass spectrometry(LDI-MS),and inductively coupled plasma optical emission spectrometry(ICP-OES).All results were subjected to multivariate statistical analysis.Four potential serum biomarkers of BC,namely,isobutyrate,pyroglutamate,choline,and acetate,were quantified with proton nuclear magnetic resonance,which had excellent predictive ability as judged by the area under the curve(AUC)value of 0.999.Two elements,Li and Fe,were also found to distinguish between cancer and control samples,as judged from ICP-OES data and AUC of 0.807(in validation set).Twenty-five putatively identified compounds,mostly related to glycans and lipids,differentiated BC from NCs,as detected using LDI-MS.Five serum metabolites were found to discriminate between tumor grades and nine metabolites between tumor stages.The results from three different analytical platforms demonstrate that the identified distinct serum metabolites and metal elements have potential to be used for noninvasive detection,staging,and grading of BC. | Krzysztof Ossolinski Tomasz Ruman Valerie Copie Brian P.Tripet Leonardo B.Nogueira Katiane O.P.C.Nogueira Artur Kołodziej Aneta Płaza-Altamer Anna Ossolinska Tadeusz Ossolinski Joanna Nizioł | 2022 | Journal of Pharmaceutical Analysis2022，12，6： | 2 |
| 2 | Molecular-beacon multiplex real-Time PCR assay for detection of Vibrio cholerae显示文摘 | ANETA J G DAVID F P | 2006 | Appl Environ Microbiol2006，72，9： | 1 |
| 3 | Benign familial neonatal convulsions caused by mutation inKCNQ3,exon 6 : a European case 显示文摘 | FISTER P ANETA SOLTIROVSKA-SALAMON A Debeljak M | 2013 | Eur J Paediatr Neurol2013，17，3： | 1 |
| 4 | Manufacturing of Highly Porous Calcium Phosphate Bioceramics via Gel-casting using Agar- ose 显示文摘 | MAREK P ANETA Z ZOFIA P | 2009 | Ceramics International2009，35，6： | 1 |
| 5 | DFT study of anovel lead structure in the isoxazole heterocyclic system 显示文摘 | ANETA J JAROSLAW P STANISLAW R | 2003 | JMol Struct2003，636，123： | 1 |
| 6 | Detection of Specific Helicobacter pylori DNA and Antigens in Stool Samples in Dyspeptic Patients and Healthy Subjects显示文摘 | Monika Wi?niewska Hans Olof Nilsson Leokadia B?lk‐Romaniszyn Tomasz Rechciński W?adys?aw Bielański Izabela P?aneta‐Ma?ecka Ma?gorzata P?onka Stanis?aw Konturek Torkel Wadstr?m Wies?awa Rudnicka Magdalena Chmiela | 2002 | Microbiology and Immunology2002，，10： | 1 |
| 7 | Total thyroidectomy is associated with increased prevalence of permanent hypoparathyroidism显示文摘 | Ireneusz N Aneta P Krzyszt P | 2014 | Medical Science2014，9，20： | 1 |
| 8 | Serological Indicators of Helicobacter pylori Infection in Adult Dyspeptic Patients and Healthy Blood Donors显示文摘 | Tomasz Rechciński Magdalena Chmiela Ewa Matecka‐Panas Izabela P?aneta‐Ma?secka Wies?awa Rudnicka | 1997 | Microbiology and Immunology1997，，5： | 1 |
| 9 | Manufacturing of Highly Porous Calcium Phosphate gioceramics via Gel casting Using Agarose Ceramics显示文摘 | Marek P Aneta Z Zofia P | 2009 | International2009，35，： | 1 |
| 10 | DFT study of a novel lead structure in the isoxazole heterocyclic system显示文摘 | Aneta J Jaroslaw P Stanislaw R | 2003 | J Mol Struct:THEOCHEM2003，636，： | 1 |
| 11 | Heat treatment in the South African Middle Stone Age: Temperature induced transformations of silcrete and their technological implications显示文摘 | Patrick S Guillaume P Aneta S | 2013 | Journal of Archaeological Science2013，40，： | 1 |
| 12 | Enhancing phytoremediation ability of Pisum sativum by EDTA application显示文摘 | ANETA P BARBARA T | 2003 | Phytochemistry2003，64，： | 1 |
| 13 | Delineating the glioblastoma stemness by genes involved in cytoskeletal rearrangements and metabolic alterations显示文摘Literature data on glioblastoma ongoingly underline the link between metabolism and cancer stemness,the latter is one responsible for potentiating the resistance to treatment,inter alia due to increased invasiveness.In recent years,glioblastoma stemness research has bashfully introduced a key aspect of cytoskeletal rearrangements,whereas the impact of the cytoskeleton on invasiveness is well known.Although non-stem glioblastoma cells are less invasive than glioblastoma stem cells(GSCs),these cells also acquire stemness with greater ease if characterized as invasive cells and not tumor core cells.This suggests that glioblastoma stemness should be further investigated for any phenomena related to the cytoskeleton and metabolism,as they may provide new invasion-related insights.Previously,we proved that interplay between metabolism and cytoskeleton existed in glioblastoma.Despite searching for cytoskeleton-related processes in which the investigated genes might have been involved,not only did we stumble across the relation to metabolism but also reported genes that were found to be implicated in stemness.Thus,dedicated research on these genes in GSCs seems justifiable and might reveal novel directions and/or biomarkers that could be utilized in the future.Herein,we review the previously identified cytoskeleton/metabolism-related genes through the prism of glioblastoma stemness. | Żaneta Kałuzińska-Kołat Damian Kołat Katarzyna Kośla Elżbieta Płuciennik Andrzej K Bednarek | 2023 | World Journal of Stem Cells2023，15，5： | 0 |
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