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| 1 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 2 | Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human alpha synuelein: Implication for alpha-synueleinopathies显示文摘 | ISHII A NONAKA T TANIGUCHI S SAOTO T ARAI T MANN D IWATSUBO T HISANAQA S GOEDERT M HASEQAWA M | 2007 | FEBS Lett2007，581，24： | 1 |
| 3 | Plasma concentrations of immunoreactive (ir) -inhibin, gonadotropins and steroid hormones during the ovulatory cycle of the duck 显示文摘 | YANG P MEDAN M S ARAI K Y | 2005 | J Reprod Dev2005，51，3： | 1 |
| 4 | A simplified model for predicting vertical temperature distribution in a large space 显示文摘 | S Togari Y Arai K Miura | 1993 | ASHRAE Trans1993，99，1： | 1 |
| 5 | Proximal femo- ral nail for treatment of trochanteric femoral fractures显示文摘 | MORIHARA T ARAI Y TOKUGAWA S | 2007 | J Or- thop Surg(Hong Kong)2007，15，3： | 1 |
| 6 | High dose rate after loading intracavitary radiation therapy for cancer of the uatering cervix显示文摘 | Arai T Nakano T Morita S | 2003 | Cancer2003，69，1： | 1 |
| 7 | A role for the apoptosis inhibitory factor AIM/Spa/Api6 in atheroselerosis develop ment显示文摘 | Arai S Shelton JM Chen M | 2005 | Cell Metab2005，1，3： | 1 |
| 8 | Enzymic protein degradation and resynthesis for protein improvement in food proteins显示文摘 | Fujimaki M Arai S Yamashita M | 1977 | Washington DC USA: American chemical Society1977，，： | 1 |
| 9 | Thermal behavior of Li1y NiO2 and the decomposition mechanism显示文摘 | Arai H Okada S Sakurai Y | 1998 | Solid State Ionics1998，109，： | 1 |
| 10 | Electrochemical and thermal behavior of LiNi1-zMzO2 (M = Co,Mn,Ti)显示文摘 | ARAI H OKADA S SAKURAI Y | 1997 | J Electrochem Soc1997，144，： | 1 |
| 11 | A systematic approach to hepatic complications in hematopoietic stem cell transplantation显示文摘 | ARAI S LEE LA VOGELSANG GB | 2002 | Journal of Hematotherapy and Stem Cell Research2002，11，： | 1 |
| 12 | A Fas! breath-hold T2- weighted MR imaging reduces interobserver variability in the di- agnosis of adenomyosis显示文摘 | Bazot M I)arai E de Givry S | 2003 | AJR2003，180，5： | 1 |
| 13 | Clinical importance of serum hepatitis B surface antigen levels in chronic hepatitis B 显示文摘 | Togo S Arai M Tawada A | 2011 | J Viral Hepat2011，18，： | 1 |
| 14 | Synthesis and anti-in- fluenza evaluation of polyvalent sialidase inhibitors bearing 4- guanidlno-NeuSAc2en derivatives 显示文摘 | HONDA T YOSHIDA S ARAI M | 2002 | Bioorganic & Medicinal Chemistry Letters2002，12，15： | 1 |
| 15 | Induced neRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription 显示文摘 | Wang X Arai S Song X | 2008 | Nature2008，454，7200： | 1 |
| 16 | Phylogenetic relationships within Cladophorales(Ulvophyceae,Chlorophyta) inferred from 18S rRNA gene sequences,with special reference to Aegagropila linnaei显示文摘 | Hanyuda T Wakana I Arai S Miyaji K WatanoY Ueda K | 2002 | J Phycol2002，38，3： | 1 |
| 17 | Mini-incision posterior approach for total hip arthroplasty显示文摘 | Nakamura S Matsuda K Arai N | 2004 | Int Orthop2004，28，： | 1 |
| 18 | A one-step process for incorporation of L-methionine into soy protein by treatment with papain显示文摘 | Yamashita M Arai S Imaizumi Y | 1979 | Journal of Agricultural and Food Chemistry1979，27，1： | 1 |
| 19 | Posterior chamber intraocular len implantation in filtered or nonfiltered glaucoma eyes显示文摘 | Yamagami S Araie M Mori M | 1994 | Jpn J Ophthalmol1994，38，7： | 1 |
| 20 | Numerical simulation of piston ring in mixed lubrication - a nonaxisymmetrical analysis 显示文摘 | Hu Y Z Cheng H S Arai T | 1994 | Transaction of ASME1994，116，： | 1 |
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