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| 1 | Psychiatric side effects of pegylated interferon alfa-2b as compared to conventional interferon alfa-2b in patients with chronic hepatitis C显示文摘AIM: To assess systematically the spectrum and extent of depressive symptoms comparing patient groups receiving peginterferon or conventional interferon.METHODS: Ninety-eight patients with chronic hepatitis C and interferon-based therapy (+ribavirin) were consecutively enrolled in a longitudinal study. Patients were treated with conventional interferon alfa-2b (48/98patients; 5 MIU interferon alfa-2b thrice weekly) or peginterferon alfa-2b (50/98 patients; 80-150 μgpeginterferon alfa-2b) in combination with weight-adapted ribavirin (800-1 200 mg/d). Repeated psychometric testing was performed before, three times during and once after antiviral therapy: Depression was evaluated by the Hospital Anxiety and Depression Scale (HADS), anger/hostility by the Symptom Checklist-90 Items Revised (SCL-90-R).RESULTS: Therapy with pegylated interferon alfa-2bproduces comparable scores for depression (ANOVA:P = 0.875) as compared to conventional interferon.Maximums of depression scores were even higher and cases of clinically relevant depression were frequent during therapy with peginterferon. Scores for anger/hostility were comparable for both therapy subgroups.CONCLUSION: Our findings suggest that the extent and frequency of depressive symptoms in total are not reduced by peginterferon. Monitoring and management of neuropsychiatric toxicity especially depression have to be considered as much as in antiviral therapy with unmodified interferon. | Michael R Kraus Arne Sch(a|¨)fer Herbert Csef Michael Scheurlen | 2005 | World Journal of Gastroenterology2005，11，12： | 5 |
| 2 | Real-life chromoendoscopy for dysplasia surveillance in ulcerative colitis显示文摘AIM To evaluate the use of chromoendoscopy for surveillance of ulcerative colitis in a real-life community hospital setting.METHODS Patients with extensive ulcerative colitis, having disease duration of more than 8 years and who presented between the years of 1999 to 2013, were offered enrolment in this single cohort prospective study. All participants underwent standard bowel preparation with sodium phosphate and chromoendoscopy. Two expert endoscopists, novice to chromoendoscopy, evaluated each segment of the colon with standarddefinition colonoscopes after spray application of 0.4% indigo carmine. All observed lesions were recorded and evaluated before being removed and/or biopsied. In addition, nontargeted biopsies were taken from each segment of the colon. The dysplasia detection rate and dysplasia detection yield were ascertained. RESULTS A total of 21 neoplastic lesions(2 carcinomas, 4 of high-grade dysplasia and 15 of low-grade dysplasia) and 27 nondysplastic lesions were detected in 16 of the total 67 patients(70% male; median disease duration: 17 years; median age at diagnosis: 25 years; 92% aminosalicylate-treated). The dysplasia detection rate was 10.5%(7/67 patients). The dysplasia detection yield was 20.8%(10/48) for targeted biopsies and 3.5%(11/318) for nontargeted biopsies. The sensitivity and specificity for the macroscopic evaluation of neoplasia using chromoendoscopy were 48% [95% confidence interval(CI): 26%-70%] and 96%(95%CI: 93%-98%), respectively. The positive predictive and negative predictive values were 42%(95%CI: 27%-59%) and 97%(95%CI: 95%-98%), respectively. A total of 19/21 dysplastic lesions were detected in mucosa with histologic inflammation.CONCLUSION Chromoendoscopy seems to be of value for dysplasia surveillance of ulcerative colitis in a community hospital setting. The yield of non-targeted biopsies is negligible. | Pasquale Klepp Anita Tollisen Arne Roseth Milada Cvancarova Smastuen Solveig N Andersen Morten Vatn Bjorn A Moum Stephan Brackmann | 2018 | World Journal of Gastroenterology2018，24，35： | 3 |
| 3 | The impact of affectivity dispositions, self-efficacy and locus of control on psychosocial adjustment in patients with epilepsy显示文摘 | Arne Gramstad Erik Iversen Bernt A Engelsen | 2001 | Epilepsy Research2001，，1： | 2 |
| 4 | Virtual permeametry on microtomographic images显示文摘 | C Arns H M A Knackstedt W V Pinczew ski | | 0，，1： | 1 |
| 5 | Pore-scale characterization of carbonates using X-ray microtomography显示文摘 | Arns C H Bauget F Limaye A | 2005 | SPEJournal2005，10，4： | 1 |
| 6 | Cost- effectiveness of linezolid versus vancomycin in mechanical ventilation-associated nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus显示文摘 | Machado A R L Arns C C Follador W | 2005 | Braz J lnfect Dis2005，9，3： | 1 |
| 7 | Orbital tumors in children:CT and MR imaging features显示文摘 | Mejdoubi M Arne JL Sevely A | | 0，，12： | 1 |
| 8 | Orbital tumors in children:CT and MR imaging features显示文摘 | Mejdoubi M Arne JL Sevely A | | 0，，12： | 1 |
| 9 | The role of the thi- oredoxin and glutaredoxin pathways in reducing pro- teindisulfide bonds in the Escherichia coli cytoplasm 显示文摘 | WILLIAM A P ARNE H JON B | 1997 | J Biol Chem1997，272，15： | 1 |
| 10 | Molecular characterizat-ion of Brazilian avian pneumovirus isolates using reverse transcription-polymerase chain reaction,restriction endonuclease analysis and sequencing of a G gene fragment显示文摘 | Dani M A C Arns C W Durigon E L | 1999 | Avian Pathol1999，28，： | 1 |
| 11 | 257 ankle arthroplasties performed in Norway between 1994 and 2005显示文摘 | Bj?rg-Tilde S Fevang Stein A Lie Leif I Havelin Johan G Brun Arne Skredderstuen Ove Furnes | 2007 | Acta Orthopaedica2007，，5： | 1 |
| 12 | Down-regulated progesterone receptor A and B coinciding with successful treatment of endometrial hyperplasia by the levonorgestrel impregnated intrauterine system显示文摘 | Orbo A Arnes M Pettersen I | 2010 | Acta Obstet Gynecol Scand2010，89，11： | 1 |
| 13 | Computation of linear elastic properties from microtomographic images:methodology and agreement between theory and experiment显示文摘 | Arns C H Knackstedt M A Pincewski W V | 2002 | Geophysics2002，67，5： | 1 |
| 14 | As-cast morphology of iron-intermetallics in Al-Si foundry alloys显示文摘 | CAMERON M D JOHN A T ARNE K D | 2005 | Scripta Materialia2005，53，： | 1 |
| 15 | Preparation and assay of mammali- an thioredoxin and thioredoxin reductase 显示文摘 | Arne' r ES Zhong L Holmgren A | 1999 | Meth Enzymol1999，300，： | 1 |
| 16 | Orbital tumors in children: CT and MR imaging features显示文摘 | Mejdoubi M Arne J Sevely A | 2007 | J Radiol2007，88，： | 1 |
| 17 | IL-10inhibits endothelium-dependent T cell eostimulation by up-Regulation of ILT3/4 in human Vascular endothelial cells 显示文摘 | Christian A Gleissner Arne Zastrow Rlaud Klingenberg | 2007 | Eur J Immunol2007，37，1： | 1 |
| 18 | Treatment resialts of endometriai hyperplasia after prospective D-score classifcation: a follow-up study comparing effect of LNG-IUD and oral progestins versus observation only显示文摘 | Orbo A Arnes M Hancke C | 2008 | Gynecol Oncol2008，111，1： | 1 |
| 19 | Supercriticalfluid extraction of free amino acids from broccoli leaves显示文摘 | E Arn a iz J Bernal M T Mart i n | 2012 | Journal of Chromatography A2012，1250，： | 1 |
| 20 | Loss of expression of MLH1,MSH2, MSH6, and PTEN related to endometrial cancer in 68 patients with endometrial hyperplasia 显示文摘 | Orbo A Nilsen M N Arnes M S | 2003 | Int J Gynecol Pathol2003，22，2： | 1 |
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