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| 1 | Epidemiology of plasmid-mediated quinolone resistance in salmonella enterica serovar typhimurium isolates from food-producing animals in Japan显示文摘 | Asai T Sato C Masani K Usui M Ozawa M Ogino T Aoki H Sawada T Izumiya H Watanabe H | | 0，，17： | 1 |
| 2 | Effects of a pure alpha/betaadrenergic receptor blocker on monocrotaline-induced pulmonary arterial hypertension with right ventricular hypertrophy in rats显示文摘 | Ishikawa M Sato N Asai K | 2009 | Circ J2009，73，12： | 1 |
| 3 | Effects a pure alpha/beta - ad- renergic receptor blocker on monocrotaline - induced pulmonary hypertension with right ventricular hypertrophy in rats显示文摘 | Ishikawa M Sato N Asai K | 2009 | Circ J2009，73，： | 1 |
| 4 | Serological diagnosis of enzootic pneumonia of swine by a double-sandwich enzyme-linked immunosorbent assay using a monoclonal antibody and recombinant antigen (P46) of Mycoplasma hyopneumoniae显示文摘 | Okada M Asai T Futo S Mori Y Mukai T Yazawa S Uto T Shibata I Sato S | 2005 | Vet Microbiol2005，105，34： | 1 |
| 5 | Prolactin inhib-its apoptosis of ovarian carcinoma cells induced by serum starvation orcisplatin treatmeat显示文摘 | ASAI SATO M NAGASHIMA Y MIYAGI E | 2005 | Int J Cancer2005，115，4： | 1 |
| 6 | Association of glycated albumin with the presence of carotid plaque in patients with type 2 diabetes 显示文摘 | Sato Y Mago M Asai A | 2013 | J Diabetes Investig2013，4，6： | 1 |
| 7 | Development of a He/CdI2 gas-jet system coupled to a surface-ionization type ion-source in JAEA-ISOL:towards determination of the first ionization potential of Lr ( Z = 103) 显示文摘 | Sato T K Asai M Sato N | 2015 | Jour-nal of Radioanalytical and Nuclear Chemistry2015，303，2： | 1 |
| 8 | Genotype and Haplotype Association Study of the STRKI Region ON 5q12 Among Japanese显示文摘 | Nakayama T Asai S Sato N Soma M | 2006 | Stroke2006，37，： | 1 |
| 9 | New approach for diagnosis in herniated lumbosacral discs显示文摘 | Asai T Sato K | 1986 | Spine1986，，： | 1 |
| 10 | Improving the accuracy of predicting secondary structure for aligned RNA sequences显示文摘 | HAMADA M SATO K ASAI K | 2011 | NAR2011，39，2： | 1 |
| 11 | Hypoadiponectinemmia in lean lactating women: prolactin hlhibits adiponectinsecretion from human adipocytes 显示文摘 | Asai - Sato M Okamoto M Endo M | 2006 | Endocr J2006，53，4： | 1 |
| 12 | Centroidfold: aweb server for RNA secondary structure prediction 显示文摘 | SATO K HAMADA M ASAI K | 2009 | Nucleic Acids Research2009，31，2： | 1 |
| 13 | Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (JCOG0305)显示文摘Objectives: Glioblastoma(GBM) is one of the worst cancers in terms of prognosis.Standard therapy consists of resection with concomitant chemoradiotherapy.Resistance to nimustine hydrochloride(ACNU),an alkylating agent,has been linked to methylguanine DNA methyltransferase(MGMT).Daily administration of procarbazine(PCZ) has been reported to decrease MGMT activity.This study investigated the efficacy of ACNU + PCZ compared to ACNU alone for GBM and anaplastic astrocytoma(AA).Methods: Patients(20-69 years) who had newly diagnosed AA and GBM were randomly assigned to receive radiotherapy with ACNU alone or with ACNU + PCZ.The primary endpoint was overall survival(OS).This was designed as a phase Ⅱ/Ⅲ trial with a total sample size of 310 patients and was registered as UMIN-CTR C000000108.Results: After 111 patients from 19 centers in Japan were enrolled,this study was terminated early because temozolomide was newly approved in Japan.The median OS and median progression-free survival(PFS) with ACNU alone(n = 55) or ACNU + PCZ(n = 56) in the intention-to-treat population were 27.4 and 22.4 months(P = 0.75),and 8.6 and 6.9 months,respectively.The median OS and median PFS of the GBM subgroup treated with ACNU alone(n = 40) or ACNU + PCZ(n = 41) were 19.0 and 19.5 months,and 6.2 and 6.3 months,respectively.Grade 3/4 hematologic adverse events occurred in more than 40% of patients in both arms,and 27% of patients discontinued treatment because of adverse events.Conclusions: The addition of PCZ to ACNU was not beneficial,in comparison with ACNU alone,for patients with newly diagnosed AA and GBM. | Shibui S Narita Y Mizusawa J Beppu T Ogasawara K Sawamura Y Kobayashi H Nishikawa R Mishima K Muragaki Y Maruyama T Kuratsu J Nakamura H Kochi M Minamida Y Yamaki T Kumabe T Tominaga T Kayama T Sakurada K Nagane M Kobayashi K Nakamura H Ito T Yazaki T Sasaki H Tanaka K Takahashi H Asai A Todo T Wakabayashi T Takahashi J Takano S Fujimaki T Sumi M Miyakita Y Nakazato Y Sato A Fukuda H Nomura K | 2013 | 中国神经肿瘤杂志2013，11，1： | 0 |
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