6篇
您的检索式：作者名="ASAKAWA Naoki"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Automation of Polishing Work by an Industrial Robot显示文摘 | Takeuchi Yoshimi Asakawa Naoki Ge Donfang | 1993 | JSME International Journal1993，36，4： | 1 |
| 2 | Miscibility and phase structure of blends of poly ( ethyl- ene oxide ) with poly ( 3-hydroxybutyrate ), poly ( 3- hydroxypropionate), and their copolymers 显示文摘 | Yang-Ho Na Yong He Naoki Asakawa | 2002 | Macromolecules2002，35，3： | 1 |
| 3 | Effects of Low Molecular Weight Compounds with Hydroxyl Groups on Properties of Poly ( L-lactic Acid ) 显示文摘 | He Yong Asakawa Naoki Li Jianchun | 2001 | Jour- nal of Applied Polylmer Science2001，82，： | 1 |
| 4 | Effect oflignin particles as a nucleating agent on crystallization ofpoly(3-hydroxybutyrate)显示文摘 | Kai Weihua Yong He Naoki Asakawa | 2004 | Journal of Applied Polymer Science2004，94，： | 1 |
| 5 | Sharp photonic Crystal Defect Modes and Their Response to Ultrashort Optical Pulses显示文摘Single photonic crystal defects based on an air-bridge structure were fabricated. We obtained sharp defect modes with quality factors higher than 600 and observed their response to ultrashort optical pulses by utilizing two-photon absorption. | Kyozo Kanamoto Sheng Lan Naoki Ikeda Yoshimasa Sugimoto Kiyoshi Asakawa Hiroshi Ishikawa | 2003 | 光学学报2003，23，S1： | 0 |
| 6 | Highly Selective Molecular Recognition of Biologically Active Substances Using Liquid Phase Separation显示文摘The development of new chiral stationary phases has been very important in the a ccurate analysis of drug enantiomers and their metabolites in biological samples during drug discovery and development. New chiral stationary phases have been d eveloped using conalbumin and flavoprotein from chicken egg whites, which have b een applied to a broad range of drug enantiomers. The application and characteri zation of these two chiral columns for high-performance liquid chromatograp hy have been documented. Both specific and non-specific interactions, based on the silica gel surface and linker moiety, influenced retention and chiral separa tion of solutes. Interactions between drug enantiomers and proteins, as a pseudo chiral stationary phase, were investigated with affinity capillary electrophore sis, in order to avoid the effects of non-specific interactions. The chiral dis crimination region for ketoprofen on the flavoprotein surface was concluded to c onsist of an α-helix structure. Studies with chemically modified flavoprot ein indicated that two types of interactions at the chiral discrimination region were required for chiral separation: a π-π interaction between a tryptophan residue and the aromatic ring of ketoprofen, and an ionic interaction between th e carboxyl group of ketoprofen and an amino and carboxyl group of the protein. I n the bod y, drugs and biologically active substances having a carboxyl group have been kn own to transform various metabolites such as acyl glucuronide. The acyl adenylat e has also been noted as a chemically active intermediate of coenzyme A ligation . Both the acyl adenylate and the acyl glucuronide produced protein adducts by r eacting with nucleophilic groups such as amino groups on protein molecules. To c haracterize both active intermediates and protein adducts, analytical techniques conferring highly selective molecular recognition, such as high-performance li quid chromatography and mass spectrometry, were required. | MANO Nariyasu ASAKAWA Naoki GOTO JunichiGraduate School of Pharmaceutical Sciences Tohoku University | 2003 | 色谱2003，21，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员