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| 1 | CA19-9 level determines therapeutic modality in pancreatic cancer patients with para-aortic lymph node metastasis显示文摘Background: In general, para-aortic lymph node(LN16) metastasis has been considered as a contraindication for pancreatic resection. However, some pancreatic cancer patients with LN16 metastasis have been reported to survive for longer than expected after pancreatectomy. The purpose of this study was to determine whether pancreatic cancer patients with LN16 metastasis might benefit from surgery.Methods: We retrospectively reviewed 201 consecutive patients with invasive pancreatic ductal adenocarcinoma who underwent surgery at Osaka National Hospital between April 2003 and December 2012.These patients included 22 patients with LN16 metastasis who underwent an extended lymphadenectomy and 25 patients who underwent a palliative surgical biliary and gastric bypass. The clinicopathological data and outcomes were evaluated using univariate and multivariate analyses.Results: The overall survival of the patients with LN16 metastasis was poorer than that of the LN16-negative patients(P = 0.0014). An overall survival analysis of the LN16-positive patients stratified according to the preoperative CA19-9 level showed a significant difference between patients with a low preoperative CA19-9 level(≤360 U/mL) and those with a high preoperative CA19-9 level(>360 U/mL)(P = 0.0301). No significant difference in overall survival of patients was observed between those with LN16 positivity and those who underwent bypass surgery. However, the overall survival of the LN16-positive patients with a CA19-9 level ≤360 U/mL(n = 11) was significantly higher than that of those who underwent bypass surgery(P = 0.0452).Conclusion: Surgical resection and extended lymphadenectomy remains an option for pancreatic cancer patients with LN16-positivity whose CA19-9 level is ≤360 U/mL. | Tadafumi Asaoka Atsushi Miyamoto Sakae Maeda Naoki Hama Masanori Tsujie Masataka Ikeda Mitsugu Sekimoto Shoji Nakamori | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，1： | 4 |
| 2 | C-reactive protein as a predictor of cardiac rupture after acute myocardial infarction显示文摘 | So Ueda Uichi Ikeda Keiji Yamamoto Masafumi Takahashi Masanori Nishinaga Naoki Nago Kazuyuki Shimada | 1996 | American Heart Journal1996，，5： | 2 |
| 3 | Blinded nonrandomized comparative study of gastric examination with a magnetically guided capsule endoscope and standard videoendoscope显示文摘 | Jean-Francois Rey Haruhiko Ogata Naoki Hosoe Kazuo Ohtsuka Noriyuki Ogata Keiichi Ikeda Hiroyuki Aihara Ileana Pangtay Toshifumi Hibi Shin-Ei Kudo Hisao Tajiri | 2012 | Gastrointestinal Endoscopy2012，，2： | 2 |
| 4 | SJES14121200034992显示文摘 | Sha Sha Zeng Taro Yamashita Mitsumasa Kondo Kouki Nio Takehiro Hayashi Yasumasa Hara Yoshimoto Nomura Mariko Yoshida Tomoyuki Hayashi Naoki Oishi Hiroko Ikeda Masao Honda Shuichi Kaneko | 2014 | Journal of Hepatology2014，，1： | 2 |
| 5 | Combined assessment of T-wave alternans and late potentials used to predict arrhythmic events after myocardial infarction显示文摘 | Takanori Ikeda Takao Sakata Mitsuaki Takami Naoki Kondo Naoki Tezuka Takeshi Nakae Mahito Noro Yoshihisa Enjoji Ryoji Abe Kaoru Sugi Tetsu Yamaguchi | 2000 | Journal of the American College of Cardiology2000，，： | 2 |
| 6 | Mucosal patterns change after Helicobacter pylori eradication:Evaluation using blue laser imaging in patients with atrophic gastritis显示文摘BACKGROUND Mucosal patterns(MPs)observed on blue laser imaging in patients with atrophic gastritis can be classified as spotty,cracked,and mottled.Furthermore,we hypothesized that the spotty pattern may change to the cracked pattern after Helicobacter pylori(H.pylori)eradication.AIM To further substantiate and comprehensively investigate MP changes after H.pylori eradication in a larger number of patients.METHODS We included 768 patients who were diagnosed with atrophic gastritis with evaluable MP using upper gastrointestinal endoscopy at the Nishikawa Gastrointestinal Clinic,Japan.Among them,325 patients were H.pylori-positive,and of them,101 patients who underwent upper gastrointestinal endoscopy before and after H.pylori eradication were evaluated for post-eradication MP changes.The patients’MPs were interpreted by three experienced endoscopists who were blinded to their clinical features.RESULTS Among 76 patients with the spotty pattern before or after H.pylori eradication,the pattern disappeared or decreased in 67 patients[88.2%,95%confidence interval(CI):79.0%-93.6%),appeared or increased in 8 patients(10.5%,95%CI:5.4%-19.4%),and showed no change in 1 patient(1.3%,95%CI:0.2%-7.1%).In 90 patients with the cracked pattern before or after H.pylori eradication,the pattern disappeared or decreased in 7 patients(7.8%,95%CI:3.8%-15.2%),appeared or increased in 79 patients(87.8%,95%CI:79.4%-93.0%),and showed no change in 4 patients(4.4%,95%CI:1.7%-10.9%).In 70 patients with the mottled pattern before or after H.pylori eradication,the pattern disappeared or decreased in 28 patients(40.0%,95%CI:29.3%-51.7%),appeared or increased in 35 patients(50.0%,95%CI:38.6%-61.4%),and showed no change in 7 patients(10.0%,95%CI:4.9%-19.2%).CONCLUSION After H.pylori eradication,MPs changed from spotty to cracked in most patients,which may help endoscopists easily and precisely evaluate H.pylori-related gastritis status. | Yoshiyuki Nishikawa Yoshio Ikeda Hidehiro Murakami Shin-Ichiro Hori Megumi Yoshimatsu Naoki Nishikawa | 2023 | World Journal of Gastroenterology2023，29，17： | 1 |
| 7 | Estimating an EQ-5D population value set,the case of Japan显示文摘 | Aki Tsuchiya Shunya Ikeda Naoki Ikegami | 2002 | Health Economics2002，11，： | 1 |
| 8 | Neutrophil depletion attenuates interleukin-8 production in mild-overstretch ventilated normal rabbit lung显示文摘 | Mariko Kotani Toru Kotani Akitoshi Ishizaka Seitaro Fujishima Hidefumi Koh Sadatomo Tasaka Makoto Sawafuji Eiji Ikeda Kiyoshi Moriyama Yoshifumi Kotake Hiroshi Morisaki Naoki Aikawa Akira Ohashi Kouji Matsushima Yuh-Chin T. Huang Junzo Takeda | 2004 | Critical Care Medicine2004，，2： | 1 |
| 9 | Influence of purity on the formation of cube texture in aluminum foils for electrolytic capacitors显示文摘 | Naoki Takata Ken-ichi Ikeda Fuyuki Yoshida | 2004 | Mater Trans2004，45，5： | 1 |
| 10 | Immunohistochemical study of p53, c-erbB-2, and PCNA in Barrett’s esophagus with dysplasia and adenocarcinoma arising from experimental acid or alkaline reflux model显示文摘 | Yukimitsu Kawaura Yasuhiko Tatsuzawa Tokio Wakabayashi Naoki Ikeda Mitsuru Matsuda Shougo Nishihara | 2001 | Journal of Gastroenterology2001，，9： | 1 |
| 11 | Apoptosis of T cells in the hepatic fibrotic tissue of the rat: a possible inducing role of hepatic myofibroblast-like cells显示文摘 | Sawako Kobayashi Shuichi Seki Norifumi Kawada Hiroyasu Morikawa Kazuki Nakatani Naoki Uyama Kazuo Ikeda Yuji Nakajima Tetsuo Arakawa Kenji Kaneda | 2003 | Cell and Tissue Research2003，，3： | 1 |
| 12 | Novel quantitative perfusion analysis with contrast-enhanced harmonic EUS for differentiation of autoimmune pancreatitis from pancreatic carcinoma显示文摘 | Hiroo Imazu Keisuke Kanazawa Naoki Mori Keiichi Ikeda Hiroshi Kakutani Kazuki Sumiyama Shoryoku Hino Tiing Leong Ang Salem Omar Hisao Tajiri | 2012 | Scandinavian Journal of Gastroenterology2012，，7： | 1 |
| 13 | Effective Hepatocyte Transplantation Using Rat Hepatocytes with Low Asialoglycoprotein Receptor Expression显示文摘 | Hirohiko Ise Toshio Nikaido Naoki Negishi Nobuhiro Sugihara Fumitaka Suzuki Toshihiro Akaike Uichi Ikeda | 2004 | The American Journal of Pathology2004，，2： | 1 |
| 14 | Hypercholesterolemia Inhibits Angiogenesis in Response to Hindlimb Ischemia: Nitric Oxide–Dependent Mechanism显示文摘 | Junli Duan Toyoaki Murohara Hisao Ikeda Atsushi Katoh Satoshi Shintani Ken-ichiro Sasaki Hidemichi Kawata Naoki Yamamoto Tsutomu Imaizumi | 2000 | Circulation: Journal of the American Heart Association . 2000 (19 S)2000，，： | 1 |
| 15 | Influence of purity on the formation of cube texture in aluminum foils for electrolytic capacitors 显示文摘 | Naoki T Ikeda K I | 2004 | Mater Trans2004，145，5： | 1 |
| 16 | Novel quantitative perfusion analysis with contrast-enhanced harmonic EUS for differentiation of autoimmune pancreatitis from pancreatic carcinoma显示文摘 | Hiroo Imazu Keisuke Kanazawa Naoki Mori Keiichi Ikeda Hiroshi Kakutani Kazuki Sumiyama Shoryoku Hino Tiing Leong Ang Salem Omar Hisao Tajiri | 2012 | Scandinavian Journal of Gastroenterology2012，，7： | 1 |
| 17 | Epithelial to Mesenchymal Transition Is a Determinant of Sensitivity to Chemoradiotherapy in Non-Small Cell Lung Cancer显示文摘 | Yasushi Shintani Akira Okimura Katsutoshi Sato Tomoyuki Nakagiri Yoshihisa Kadota Masayohi Inoue Noriyoshi Sawabata Masato Minami Naoki Ikeda Kunimistu Kawahara Tomoshige Matsumoto Nariaki Matsuura Mitsunori Ohta Meinoshin Okumura | 2011 | The Annals of Thoracic Surgery2011，，5： | 1 |
| 18 | Usefulness of procalcitonin serum level for the discrimination of severe sepsis from sepsis: a multicenter prospective study显示文摘 | Shigeatsu Endo Naoki Aikawa Seitaro Fujishima Isao Sekine Kazuhiro Kogawa Yasuhiro Yamamoto Shigeki Kushimoto Hidekazu Yukioka Noboru Kato Kyoichi Totsuka Ken Kikuchi Toshiaki Ikeda Kazumi Ikeda Hiroyuki Yamada Kazuaki Harada Shinji Satomura | 2008 | Journal of Infection and Chemotherapy2008，，3： | 1 |
| 19 | 采用EQ-5D测量日本Ⅱ型糖尿病病人健康相关生存质量显示文摘目的:采用日文版欧洲生命质量量表(EQ-5D)测量糖尿病病人健康相关生存质量(HRQL),考察病人临床状况与健康状况(health status)之间的关系。方法:1998年11月17日至12月24日,对到日本琦玉县(Saitama Prefecture)一家医院门诊的220名Ⅱ型糖尿病病人开展了该项研究。病人采用5个维度以及视觉模拟法(visual analog scale,VAS)评价了他们的健康状况。EQ- 5D积分根据病人回答的5个问题的答案,采用事先确定的日文版分值表计算。结果:没有病人回答'极度严重'等级的问题;有并发症的病人在'活动性(mobility)'和'焦虑与沮丧(anxiety/ depression)'两个维度回答'有些问题'的频率显著高于无并发症的病人('活动性':27.4%和14.4%;'焦虑与沮丧':25.7%和13.5%)。有并发症病人EQ-5D平均得分为0.846(95%置信区间0.817~0.874),无并发症病人平均得分为0.884(95%置信区间0.855~0.914)。有糖尿病并发症病人与无糖尿病并发症病人的VAS得分统计学差异显著,有视网膜病变病人与无视网膜病变病人的VAS得分有显著差异。结论:本研究的发现提示我们重视糖尿病病人健康状况测量的价值,因为这使我们能比较全面地评价病人的健康情况,并且为病人主观症状与实验室检查数据增加另一个维度的资料。 | Hiroyuki Sakamaki Shunya Ikeda Naoki Ikegami Yasuko Uchigata Yasuhiko Iwamoto Hideki Origasa Toshiki Otani Yoichi Otani 李洪超 | 2008 | 中国药物经济学2008，0，4： | 1 |
| 20 | Impact of culprit plaque volume and composition on myocardial microcirculation following primary angioplasty in patients with ST-segment elevation myocardial infarction: Virtual histology intravascular ultrasound analysis显示文摘 | Kousei Ohshima Shuntaro Ikeda Hisaki Kadota Kenichi Yamane Naoki Izumi Kiyotaka Ohshima Mareomi Hamada | 2012 | International Journal of Cardiology2012，，： | 1 |
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