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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | IL-17-producing human peripheral regulatory T cells retain suppressive function显示文摘 | Beriou G Costantino C M Ashley C W | 2009 | Blood2009，113，18： | 1 |
| 3 | Analysis of volatile organic compounds in mainstream cigarette smoke显示文摘 | Polzin G M Kosa-Maines R E Ashley D L | 2007 | Environmental Science & Technology2007，41，4： | 1 |
| 4 | Outpatient management of patients with low-risk upper-gastrointestinal haemorrhage: multicentre validation and prospective evaluation显示文摘 | AJ Stanley D Ashley HR Dalton C Mowat DR Gaya E Thompson U Warshow M Groome A Cahill G Benson O Blatchford W Murray | 2009 | The Lancet2009，，9657： | 1 |
| 5 | Classification of large-scale subaqueous bedforms:a new look at an old problem显示文摘 | Ashley G M | | 0，，01： | 1 |
| 6 | The nature and pollutant role of solids at the water-sediment interface in combined sewer networks显示文摘 | Cheebo G Ashley R Gromaire M C | 2003 | Water Sci Technol2003，47，4： | 1 |
| 7 | The orphan G protein-coupled receptors GPR41 and GPR43 are ae tivated by propionate and other short chain carboxylic acids显示文摘 | Andrew J B Susan M G Ashley A B | 2003 | J Biol Chem2003，278，11： | 1 |
| 8 | InSbl_x Nx growth and devices 显示文摘 | Ashley T Burke T M Pryee G J | 2003 | Solid-State Electronics2003，47，3： | 1 |
| 9 | Interpretation of polymodal sediments显示文摘 | Ashley G M | 1978 | Journal of Geology1978，86，： | 1 |
| 10 | Rates and patterns of Late Cenozoic denudation in the northernmost Atlantic Coastal Plain and Piedmont显示文摘 | STANFORD S D ASHLEY G M RUSSELL E W B | 2002 | Geological Society of American Bulletin2002，114，： | 1 |
| 11 | Interpretation of Polymodal Sediments显示文摘 | ASHLEY G M | 1978 | The Journal of Geology1978，86，： | 1 |
| 12 | Precipitable Water Vapor above Dome A, Antarctica, Determined from Diffuse Optical Sky Spectra 显示文摘 | Sims G Ashley M C B Cui X et at | 2012 | Publications of the Astronomical Society of the Pacific2012，124，911： | 1 |
| 13 | In vivo and in vitro characterization of a novel neuroprotective strategy for stroke: isehemie postconditioning显示文摘 | Pignataro G Meller R Inoue K Ordonez A N Ashley M D Xiong Z | 2008 | J Cereb Blood Flow Metab2008，28，： | 1 |
| 14 | The calculation of plate efficiency under conditions of finite mixing in both phases in multiplate columns, and the potential advantage of parallel flow 显示文摘 | ASHLEY M J HASELDEN G G | 1970 | Chemical Engineering Science1970，，25： | 1 |
| 15 | Analysis of volatile organic compounds in mainstream cigarette smoke显示文摘 | Polzin G M Kosa-Maines R E Ashley D L | | 0，，4： | 1 |
| 16 | The nature and pollutant role of solids at the water-sediment interface in combined sewer networks 显示文摘 | CHEBBO G ASHLEY R GROMAIRE M C | 2005 | Water Science and Technology2005，47，3： | 1 |
| 17 | Interpretation of polymodal sediments 显示文摘 | Ashley G M | 1978 | Journal of Geology1978，86，： | 1 |
| 18 | Classification of large scale subaqueous bed forms, a new look at an old problem显示文摘 | ASHLEY G M | 1990 | J Sediment Petrol1990，60，： | 1 |
| 19 | Classification of large-scale subaqueous bedform: New look at old problem显示文摘 | Ashley G M | 1990 | Journal of sedimentary Petrology1990，60，1： | 1 |
| 20 | Late Quatermary sequence stratigraphy of a slowly subsiding passive margin, New Jersey Continental Shelf显示文摘 | Carey J S Sheridan R E Ashley G M | 1998 | AAPG Bulletin1998，82，5： | 1 |
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