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| 1 | Methanolic extract of Momordica cymbalaria enhances glucose uptake in L6 myotubes in vitro by up-regulating PPAR-γ and GLUT-4显示文摘The present study was undertaken to evaluate the influence of the methanolic fruit extract of Momordica cymbalaria(MFMC) on PPARγ(Peroxisome Proliferator Activated Receptor gamma) and GLUT-4(Glucose transporter-4) with respect to glucose transport. Various concentrations of MFMC ranging from 62.5 to 500 μg·mL-1 were evaluated for glucose uptake activity in vitro using L6 myotubes, rosiglitazone was used as a reference standard. The MFMC showed significant and dose-dependent increase in glucose uptake at the tested concentrations, further, the glucose uptake activity of MFMC(500 μg·mL-1) was comparable with rosigilitazone. Furthermore, MFMC has shown up-regulation of GLUT-4 and PPARγ gene expressions in L6 myotubes. In addition, the MFMC when incubated along with cycloheximide(CHX), which is a protein synthesis inhibitor, has shown complete blockade of glucose uptake. This indicates that new protein synthesis is required for increased GLUT-4 translocation. In conclusion, these findings suggest that MFMC is enhancing the glucose uptake significantly and dose dependently through the enhanced expression of PPARγ and GLUT-4 in vitro. | Puttanarasaiah Mahesh Kumar Marikunte V Venkataranganna Kirangadur Manjunath Gollapalle L Viswanatha Godavarthi Ashok | 2014 | Chinese Journal of Natural Medicines2014，12，12： | 2 |
| 2 | Recent advances in biologicalproduction of 3-hydroxypropionic acid 显示文摘 | KUMAR V ASHOK S PARIC S | 2013 | BiotechnologyAdvances2013，31，6： | 1 |
| 3 | Rao Studieson thermal and morphologyical behavior of silieonized epoxy bismaleimide matrices 显示文摘 | A Ashok Kumar M Alagar R M V G K | 2001 | J Appl Polym Sci2001，81，： | 1 |
| 4 | Recent advances in biological production of 3-hydroxypropionic acid显示文摘 | KUMAR V ASHOK S PARK S | 2013 | Biotechnology Advances2013，31，6： | 1 |
| 5 | Recent advances in biological production of 3-hydroxypropionic acid 显示文摘 | Kumar V Ashok S Park S | 2013 | Bioteehnol Adv2013，31，6： | 1 |
| 6 | Indias casting Industry Holds Opportunities显示文摘 | Swartzlander M Ashok Kumar Raviraj B V | 2009 | Challenges Modern Casting American Foundry Society2009，2009，12： | 1 |
| 7 | Recent advances in biologi- cal production of 3-hydroxypropionic acid 显示文摘 | Kumar V Ashok S Park S | 2013 | Biotech- nology Advances2013，31，6： | 1 |
| 8 | Sythesis and characterization of siliconized epoxy-1,3-bis (maleimido) benzene intercrossIinked matrix materials显示文摘 | ASHOK KUMAR A ALAGAR M RAO R M V G K | 2002 | Polymer2002，43，： | 1 |
| 9 | Synthesis and characterization of high performance polymeric hybrid siliconized epoxy composites for aerospace applications显示文摘 | Alagar M Thanikai Velan T V Ashok Kumar A | 1999 | Materials and Manufacturing Processes1999，14，1： | 1 |
| 10 | Effects of deposition temperature on materials properties of magnetron sputtered titanium nitride coatings on mild steel substrates with Ni interlayer显示文摘 | Ashok K Selvan G Kumar V Senthil | | 0，，08： | 1 |
| 11 | Synthesis and Characterization of Siliconized Epoxy--1,3-bis (maleimide)benzene Intercrosslinked Matrix Materials显示文摘 | Ashok Kumar A Alagar M Rao R M V G K | 2002 | Polymer2002，43，3： | 1 |
| 12 | Surface-enhanced Raman scattering studies of human transcriptional coactivator p300显示文摘 | Pavan Kumar G V Ashok Reddy B A Arif M | | 0，，33： | 1 |
| 13 | Aldehyde dehydrogenase activity is important to the production of 3-hydroxypropionic acid from glycerol by recombinant Klebsiella pneumonia 显示文摘 | Ko Y Ashok S Zhou SF Kumar V Park S | 2012 | Process Biochem2012，47，： | 1 |
| 14 | Studies on thermal and morphological behavior of siliconized epoxy bismaleimide matrices 显示文摘 | A Ashok Kumar M Alagar R M V G K Rao | 2001 | J Appl Polym Sci2001，81，10： | 1 |
| 15 | Sequential constraint imposition for dimension-driven solid models显示文摘 | Ashok V Kumar Lichao Yu | 2001 | Computer-Aided Design2001，6，： | 1 |
| 16 | Studies on thermal and morphological behavior of siliconized epoxy bismaleimide matrices 显示文摘 | A Ashok Kumar M Alagar R M V G K Rao | 2001 | J Appl Polym Sci2001，81，10： | 1 |
| 17 | Synthesis and characterization of high performance polymeric hybrid siliconized epoxy composites for aerospace applications显示文摘 | Alagar M Thanikai Velan T V Ashok Kumar A | 1999 | Materials and Manufacturing Processes1999，14，1： | 1 |
| 18 | Sequential Constraint Imposition for Dimension- driven Solid Models显示文摘 | ASHOK V Kumar YU Lichao | 2001 | Computer Aided Design2001，33，6： | 1 |
| 19 | Second law analysis of a waste heat recovery steam generator显示文摘 | Reddy B V Ramkiran Y Ashok Kumar K | 2002 | International Journal of Heat and Mass Transfer2002，45，9： | 1 |
| 20 | Antioxidant and an- ti -cancer potentials of rheum emodi rhizome extracts 显示文摘 | Rajkumar V Guha G Ashok Kumar R | 2011 | Evid Based Complement Alternat Med2011，，： | 1 |
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