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| 1 | Analysis of the relationship between bile duct and duodenal microbiota reveals that potential dysbacteriosis is the main cause of primary common bile duct stones显示文摘Bacteria play an important role in the formation of primary Common Bile Duct(CBD)stones.However,the composition and function of the microbiota of bile duct in patients with primary CBD stones remained to be explored.We utilized the 16S rRNA gene high-throughput sequencing technology to analyze the microbial diversity and community composition of biliary and duodenal microbiota in 15 patients with primary CBD stones and 4 patients without biliary tract diseases.Alpha diversity analysis showed that the microbiota richness was similar in bile and intestinal fluid;Beta diversity analysis showed that there were differences in the composition between biliary microbiota and the duodenal microbiota,but the abundance of the main groups showed similarities.The composition of the biliary microbiota from gallstone patients was more complex,as was the duodenal microbiota.Proteobacteria and Firmicutes were the dominant bacteria at phylum level,accounting for at least 75%of the total reads in each subgroup.Pseudomonas and EscherichiaShigella were the major genus among subgroups,but Escherichia-Shigella had increased abundance in duodenal microbiota with primary choledocholithiasis,which may play an important role in stone formation.It is noteworthy that Clostridiumsensu_stricto,Lachnospiraceae_UCG-008,Butyrivibrio and Roseburia which could produce short chain fatty acids(SCFAs),were significantly decreased in biliary microbiota with primary CBD stones(p<0.05).Our study provided new insights into the compositional of normal biliary microbiota.The micro-ecology of biliary and duodenal in patients with stones is complex and closely related,and there is a potential for dysbacteriosis.The decrease in abundance of certain major acid-producing bacteria affects the health of the biliary tract and thus leads to the formation of stones. | Zhitang Lyu Tingting Yu Lichao Zhang Xiaona Xu Yijun Zhang Jihong Li Zhirong Li Wei Zhang Senlin Hou | 2021 | Synthetic and Systems Biotechnology2021，6，4： | 2 |
| 2 | An object-oriented modular framework for implementing the finite element method 显示文摘 | YU Lichao KUMMAR A V | 2001 | Computers & Structures2001，79，9： | 1 |
| 3 | Characterization and flocculation mechanism of a bioflocculant from hydrolyzate of rice stover显示文摘 | Junyuan Guo Jing Yu Xin Xin Changwu Zou Qingfeng Cheng Huaijin Yang Lichao Nengzi | 2014 | Bioresource Technology2014，，： | 1 |
| 4 | Orally administered oleoylethanolamide protects mice from focal cerebral ischemic injury by activating peroxisome proliferator-activated receptorα显示文摘 | Yu Zhou Lichao Yang Ang Ma | 2012 | Neuropharmacology2012，，63： | 1 |
| 5 | Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrestin human gastric cancer cells显示文摘 | Jian Pan Hai Hu Zhuan Zhou Lichao Sun Liang Peng Long Yu Lixin Sun Jun Liu Zhihua Yang Yuliang Ran | 2010 | Oncology Reports2010，，1： | 1 |
| 6 | Puerarin blocks the signaling transmission mediated by P2X 3 in SG and DRG to relieve myocardial ischemic damage显示文摘 | Shuangmei Liu Chunping Zhang Qingming Shi Guilin Li Miaomiao Song Yun Gao Changshui Xu Hong Xu Bo Fan Shicheng Yu Chaoran Zheng Qicheng Zhu Bing Wu Lichao Peng Huangui Xiong Qin Wu Shangdong Liang | 2014 | Brain Research Bulletin2014，，： | 1 |
| 7 | Sequential constraint imposition for dimension-driven solid models显示文摘 | Ashok V Kumar Lichao Yu | 2001 | Computer-Aided Design2001，6，： | 1 |
| 8 | FERONIA receptor kinase pathway suppresses abscisic acid signaling in Arabidopsis by activating ABI2 phosphatase显示文摘 | Feng Yu Lichao Qian Candida Nibau Qiaohong Duan Daniel Kita Kathryn Levasseur Xiaoqian Li Changqing Lu Hui Li Congcong Hou Legong Li Bob B. Buchanan Liangbi Chen Alice Y. Cheung Dongping Li Sheng Luan | 2012 | Proceedings of the National Academy of Sciences2012，，36： | 1 |
| 9 | Sequential Constraint Imposition for Dimension- driven Solid Models显示文摘 | ASHOK V Kumar YU Lichao | 2001 | Computer Aided Design2001，33，6： | 1 |
| 10 | Sequential constraint imposition for dimension-driven solid models显示文摘 | Kumar A V Yu Lichao | | 0，，06： | 1 |
| 11 | Sequential constraint imposition for dimension-driven solid models显示文摘 | Kumar Ashok V Yu LiChao | 2001 | Computer-Aided Design2001，33，6： | 1 |
| 12 | Effect of aging on islet beta-cell function and its mechanisms in Wistar rats显示文摘 | Zhaoyan Gu Yingzhen Du Yu Liu Lichao Ma Lin Li Yanping Gong Hui Tian Chunlin Li | 2012 | AGE2012，，6： | 1 |
| 13 | Hydrogen Gas Improves Survival Rate and Organ Damage in Zymosan-Induced Generalized Inflammation Model显示文摘 | Keliang Xie Yonghao Yu Zishen Zhang Wenbo Liu Yuping Pei Lize Xiong Lichao Hou Guolin Wang | 2010 | Shock2010，，5： | 1 |
| 14 | PROTECTIVE EFFECTS OF HYDROGEN GAS ON MURINE POLYMICROBIAL SEPSIS VIA REDUCING OXIDATIVE STRESS AND HMGB1 RELEASE显示文摘 | Keliang Xie Yonghao Yu Yuping Pei Lichao Hou Shaoyang Chen Lize Xiong Guolin Wang | 2010 | Shock2010，，1： | 1 |
| 15 | Sequential constraint imposition for dimension-driven solid models显示文摘 | Ashok V Kumar Lichao Yu | 2001 | Computer Aided Desigaa2001，33，6： | 1 |
| 16 | Preconditioning with Isoflurane Produces Dose-Dependent Neuroprotection via Activation of Adenosine Triphosphate-Regulated Potassium Channels After Focal Cerebral Ischemia in Rats显示文摘 | Lize Xiong Yu Zheng Mingchun Wu Lichao Hou Zhenghua Zhu Xijing Zhang Zhihong Lu | 2003 | Anesthesia & Analgesia2003，，1： | 1 |
| 17 | ERCP combined with colonoscopy in the treatment of biliary-colonic fistula:case report and literature review显示文摘Introduction Internal biliary fistula is a potentially serious complication of laparoscopic cholecystectomy[1].Biliary-colonic fistula is a rare type of internal biliary fistula.Formation of a biliary-colonic fistula can occur as the result of surgical injury,stone obstruction,and biliary hypertension.More infrequent causes include intestinal ulcer and malignant tumor.The formation of a fistula also has the effect of infection and inflammation.While very few cases of biliary-colonic fistulas have been reported,these cases typically present with the aforementioned clinical presentations[2,3].In the present case,a biliary-colonic fistula resulting from bile-duct injury after laparoscopic cholecystectomy was identified by endoscopic retrograde cholangiopancreatography(ERCP).We innovatively adopted ERCP combined with colonoscopy to clamp the sinus tract for the patient. | Hongfei He Tingting Yu Yaoting Li Senlin Hou Lichao Zhang | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 18 | Novel per-oral cholangioscopy for treatment of occult accessory hepatic duct stones显示文摘Introduction The accessory hepatic duct is a variation of the biliary tree and is considered to be an important factor contributing to bile duct injury during surgery[1].Accessory hepatic duct stones are a rare form of cholelithiasis.The angle at which the accessory hepatic duct opens into the common bile duct makes it difficult to remove stones using conventional endoscopic retrograde cholangiopancreatography(ERCP).We reported a rare and insidious case of an accessory hepatic duct stone.The patient’s abdominal computed tomography(CT)did not reveal any abnormalities,but endoscopic ultrasound revealed a stone in the bile duct opening into a branch of the common bile duct.The patient underwent ERCP,and cholangiography showed no abnormalities.However,the accessory hepatic duct opening was found in the common bile duct and the accessory hepatic duct stones were successfully removed using the EyeMax Choledochoscope System Digital Controller(Nanjing,China). | Tingting Yu Yaoting Li Hongfei He Senlin Hou Lichao Zhang | 2023 | Gastroenterology Report2023，11，1： | 0 |
| 19 | Redesign of a short-chain dehydrogenase/reductase for asymmetric synthesis of ethyl (R)-2-hydroxy-4-phenylbutanoate based on per-residue free energy decomposition and sequence conservatism analysis显示文摘As an important building block for the synthesis of angiotensin-converting enzyme inhibitors,ethyl(R)-2-hy-droxyl-4-phenylbutanoate[(R)-HPBE]has attracted increasing attention.The key to industrial biosynthesis of(R)-HPBE is a biocatalyst that efficiently reduces ethyl 2-oxo-4-phenylbutanoate(OPBE)with high R-enantiose-lectivity.This paper proposed a strategy for identifying key residues involved in enantioselectivity control based on per-residue free energy decomposition and sequence conservatism analysis.Using this strategy,4 noncon-servative sites with high energy contribution to binding of OPBE were chosen as engineering targets,generating variant Mu27 with 99%conversion and 98%(R)ee value at substrate loading of up to 500 mmol/L.MD simu-lations suggested the higher stability and formation probability of Mu27-OPBEproR prereaction state as key rea-sons for the excellent R-enantioselectivity of Mu27 towards OPBE.The success in this study provides a viable approach for rational design of alcohol dehydrogenases with high enantioselectivity towards unnatural substrates. | Bingmei Su Lian Xu Xinqi Xu Lichao Wang Aipeng Li Juan Lin Lidan Ye Hongwei Yu | 2020 | Green Synthesis and Catalysis2020，1，2： | 0 |
| 20 | Short-process recycling of Nd-Fe-B sintered magnet sludge wastes:Challenges and approaches显示文摘Nd-Fe-B sintered magnet sludge wastes are one kind of typical commodity of recyclable rare-earth permanent magnet resources,and recycling such kind of wastes with economical and environmentally friendly techniques is crucial to the sustainable rare-earth industry.However,the current multistage wet process recycling technique for the sludge wastes involves high fabrication cost,excessive energy consumption,and heavy environmental burden.Therefore,short-process recycling techniques for Nd-Fe-B sintered magnet wastes have drawn increasing attention in the past decades.In this paper,we review recent efforts into short-process recycling Nd-Fe-B sintered magnet sludge wastes with emphasis on in-situ recycling techniques. | Liying Cong Lichao Yu Quangui Zhou Qingmei Lu Ming Yue | 2023 | Journal of Rare Earths2023，41，10： | 0 |
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