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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Cranioplasty: cosmetic or therapeutic 显示文摘 | Dujovny M Aviles A Agner C el al | 1997 | Surg Neurol1997，47，： | 1 |
| 3 | Effect of a wound healing electromagnetic field on inflammatory cytokine gene expression in rats显示文摘 | Jasti A C Wetzel B J Aviles H | 2001 | Biomed Sci Instrum2001，37，： | 1 |
| 4 | Rituximab and chemotherapy in primary gastric lymphoma显示文摘 | Aviles A Castafieda C Cleto S | 2009 | Cancer Biother Radiopharm2009，24，1： | 1 |
| 5 | Fractal analysis applied to characteristic segments of the san andreas fault显示文摘 | Aviles C A Scholz C H | 1987 | Journal of Geophysical Research1987，92，1： | 1 |
| 6 | Scaling differences between large interpolate and intraplate earthquakes显示文摘 | Scholz C H Aviles C A Wesnousky S G | 1986 | Bull Seismol Soe Am1986，76，1： | 1 |
| 7 | The fractal geometry of faults and faulting 显示文摘 | SCHOLZ C H AVILES C A | 1986 | 5th Sympon Earth quake Source Mechanisms1986，，： | 1 |
| 8 | Results of a phase Ⅲ clinical trial: CHOP versus CMED in peripheral T-cell lymphoma unspecified显示文摘 | Aviles A Castaneda C Neri N | 2008 | Med Oncol2008，25，3： | 1 |
| 9 | Crackpath in foam cored DCB sandwich fracture specimens显示文摘 | Carlsson L A Matteson R C Aviles F Loup D C | 2005 | Composites Science and Technology2005，65，1516： | 1 |
| 10 | Fractal dimension of the 1906 San Andress fault and 1915 Pleasant Valley faults (abstract)显示文摘 | Scholz C H Aviles C A | 1985 | Earthquakes Notes1985，55，： | 1 |
| 11 | Rituximab and chemotherapy in primary gastric lymphoma显示文摘 | Aviles A Castaneda C Cleto S | 2009 | Cancer Biother Radiopharm2009，24，1： | 1 |
| 12 | Rituximab and chemotherapy in primary gastric lymphoma显示文摘 | Aviles A Castaneda C Cleto S | 2009 | Cancer Biother Radiopharm2009，24，1： | 1 |
| 13 | Experimental support for the use of egg uniformity in parasite egg discrimination by cuckoo hosts显示文摘 | Moskát C Avilés JM Bán M Hargitai R Z(o)lei A | | 0，，： | 1 |
| 14 | Thermal study of the effect of several solvents on polymerization of acrylonitrile and their subsequent pyrolysis显示文摘 | Sanchez-Soto P J Aviles M A del Rio J C | 2001 | Journal of analytical and applied pyrolysis2001，5859，： | 1 |
| 15 | Fractal analysis applied to characteristic segments of the San Andreas Fault显示文摘 | Aviles C A Acholz C Z Boatwright J | 1987 | J Geophysics Res1987，92，23： | 1 |
| 16 | Experimental support for the use of egg uniformity in parasite egg discrimination by cuckoo hosts显示文摘 | Moskát C Avilés JM Ban M Hargitai R Zolei A | | 0，，： | 1 |
| 17 | Fractal analysis applied to characteristic segments of the San Andreas fault显示文摘 | AVILES C A SCHOLZ C H BOATWRIGHT J | 1987 | Journal of Geophysical Research1987，92，1： | 1 |
| 18 | Reversion of advanced ebola virus disease in nonhuman primates with Zmapp显示文摘 | Qiu X Wong G Audet J Bello A Fernando L Alimonti JB Fausther-Bovendo H Wei H Aviles J Hiatt E Johnson A Morton J Swope K Bohorov O Bohorova N Goodman C Kim D Pauly M H Velasco J Pettitt J Olinger G G Whaley K Xu B Strong J E Zeitlin L Kobinger G P | 2014 | Nature2014，514，7520： | 1 |
| 19 | Fractal analysis applied to characteristic segments of the San Andreas Fault显示文摘 | AVILES C A SCHOLZ C Z BOATWRIGHT J | 1987 | J Geophys Res1987，92，： | 1 |
| 20 | Scaling differences between large interplate and intraplate earthquakes显示文摘 | SCHOLZ C H AVILES C A WESNOUSKY S G | 1986 | Bulletin of the Seismological Society of America1986，76，1： | 1 |
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