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| 1 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 2 | A new minimally invasive experimental spinal cord injury model in rabbits显示文摘 | Baydin A Cokluk C Aydin K | | 0，，03： | 1 |
| 3 | Overprinting Faulting Me- chanisms in High Porosity Sandstones of SE Utah 显示文摘 | Davatzes N C Aydin A | 2003 | Journal of Structural Geology2003，25，11： | 1 |
| 4 | Magnetic susceptibility and heavy-metal contamination in topsoils along the Izmit Gulf coastal area and Izaytas (Turkey) 显示文摘 | CANBAY M AYDIN A KURTULUS C | 2010 | Journal Applied Geophys- ical2010，70，6： | 1 |
| 5 | Evidence of excessive releases of metals from primitive E-waste processing in Guiyu,China显示文摘 | Wong C S C Duzgoren-Aydin N S Aydin A | 2007 | Environmental Pollution2007，148，1： | 1 |
| 6 | Effect of steel fibers on the mechanical properties of natural lightweight aggregate concrete显示文摘 | DUZGUN OguzAkm GUL R AYDIN A C | 2005 | Materials Letters2005，59，27： | 1 |
| 7 | Presurgical ultrasound-assisted neuro-examination in the surgical repair of peripheral nerve injury 显示文摘 | Cokluk C Aydin K Senel A | 2004 | Minim Invasive Neurosurg2004，47，3： | 1 |
| 8 | Soft-tissue reconstruction of sole and heel defects with free tissue transfers显示文摘 | Yucel A Senyuva C Aydin Y | 2000 | Ann Plast Surg2000，44，3： | 1 |
| 9 | Theeffects of G-CSF and naproxen sodium on the serum TGF-betal level and fracture healing in rat tibias显示文摘 | KAYGUSUZ M A TURAN C C AYDIN N E | 2006 | Life Sci2006，80，1： | 1 |
| 10 | A new minimally invasive experimental spinal cord injury model in rabbits 显示文摘 | Baydin A Cokluk C Aydin K | 2007 | Minim Invasive Neurosurg2007，50，3： | 1 |
| 11 | Serum insulin, leptin, and neuropeptide y levels in epileptic children treated with valproate显示文摘 | Aydin K Serdaroglu A Okuyaz C | 2005 | J Child Neurol2005，20，10： | 1 |
| 12 | Fundamental principals of tumor necrosis factor - alpha gene therapy approach and implications for patients with lung carcinoma显示文摘 | SANGLIOGLU A D AYDIN C BOZCUK H | 2004 | Lung Cancer2004，44，2： | 1 |
| 13 | Structural analysis of the essential resuscitation promoting factor YeaZ suggests a mechanism of nucleotide regulation through dimer reorganization 显示文摘 | Aydin I Saijo-Hamano Y Namba K Thomas C Roujeinikova A | 2011 | PLoS ONE2011，6，23： | 1 |
| 14 | A finite element-spherical harmonics radiation transport model for photon migration in turbid media显示文摘 | Aydin E D de Oliveira C R E Goddard A J H | 2004 | Journal of Quantitative Spectro-scopy and Radiative Transfer2004，84，3： | 1 |
| 15 | Fastforward solvers for the low-frequency detection of buried dielectric objects显示文摘 | CUI T J CHEW W C AYDINER A A | | 0，，09： | 1 |
| 16 | Human model simulating right ventricular outflow tract tachycardia by high - frequency stimulation in the left pulmonary artery: autonomies and idiopathic ventricular ar- rhythmias 显示文摘 | Hasdemir C Alp A Aydin M | 2009 | J Cardiovasc Electrophysiol2009，20，7： | 1 |
| 17 | Transcriptional profiling of septal wall of the right ventricular outflow tract in patients with idiopathic ventricular arrhythmias显示文摘 | Hasdemir C Aydin H H Celik H A | 2010 | Pacing Clin Electrophysiol2010，33，2： | 1 |
| 18 | Effects of mesiodistal inclination of implants on stress distribution in implant-supported fixed prostheses显示文摘 | Caqlar A Aydin C Ozen J | 2006 | Int J Oral Maxillofac Implants2006，21，1： | 1 |
| 19 | Human model simulating right ventricular outflow tract tachycardia by high-frequency stimulation in the left pulmonary artery: autonomies and idiopathic ventrieular arrhythmias显示文摘 | Hasdemir C Alp A Aydin M | 2009 | J Cardiovasc Electrophysiol2009，20，7： | 1 |
| 20 | Midterm outcome after unilateral approach for bilateral decompression of lumbar spinal stenosis:5-year prospective study显示文摘 | Cavusoglu H Kaya R A Türkmenoglu O N Tuncer C Colak I Aydin Y | 2007 | Eur Spine J2007，16，： | 1 |
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