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	题名	作者	年代	出处	被引量
1	肿瘤相关糖蛋白-72特异性T细胞活化融合基因的分子克隆显示文摘目的克隆正常人T细胞CD3ξ胞内区、跨膜区基因,将其与肿瘤相关抗原肿瘤相关糖蛋白-72(TAG-72)特异性单链抗体基因克隆入真核表达载体。方法用逆转录-聚合酶链反应(RT-PCR)法从正常人外周血T细胞扩增出CD3ξ胞内区、跨膜区基因;应用PCR法扩增抗TAG-72特异性单链抗体(scFv)基因;将该单链抗体与CD3ξ基因顺序克隆构建重组真核表达载体scFv-CD3ξ-pcDNA3.0并测序。结果抗TAG-72 scFv cDNA片段为729 bp,与已知的序列相符;CD3ξ胞内区、跨膜区的cDNA片段为306 bp,与Gene Bank公布的序列一致。重组的表达载体经酶切琼脂糖电泳及测序加以证实。结论成功构建了含抗肿瘤相关抗原TAG-72scFv及CD3ξ胞内区、跨膜区序列的重组表达载体scFv-CD3ξ-pcDNA3.0,为制备消化道肿瘤靶向性嵌合锚定T细胞奠定了实验基础。	徐宏勇徐立李开宗窦科峰刘彦仿 Hinrich Abken	2003	中华实验外科杂志2003，20，2：	2
2	B7-1 and B7-2 act differentially in the induction of a T cell response: their impact for a HLA-matehed and HLA-mismatehed anti-tumor immunotherapy 显示文摘	Krenfeld K Abken H seliger B	2005	Int J Cancer2005，117，5：	1
3	The weal and woe of costimula- tion in the adoptive therapy of cancer with chimeric antigen receptor ( CAR) -redirected T cells显示文摘	Hombach AA Holzinger A Abken H	2013	Curr Mol Med2013，13，7：	1
4	HLA-G and MIC expression in tumors and their role in anti-tumor immunity显示文摘	Seliger B Abken H Ferrone S	2003	Trends Immunol2003，24，2：	1
5	CAR T cells transform to trucks:Chim- eric antigen receptor- redirected T cells engineered to deliver in- ducible IL - 12 modulate the tumour stroma to combat cancer显示文摘	Chmielewski M Abken H	2012	Cancer Immunol Immun2012，61，8：	1
6	TRUCKs: the fourth generation of CARs显示文摘	Chmieleski M Abken H		Expert Opin Biol Ther0，15，8：	1
7	Depletion of annexin A5, annexin A6, and collagen X causes no gross changes in matrix vesicle–mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response显示文摘	Ivan Grskovic Anna Kutsch Christian Frie Gergely Groma Jacek Stermann Ursula Schl?tzer‐Schrehardt Anja Niehoff Stephen E Moss Sabrina Rosenbaum Ernst P?schl Markus Chmielewski Gunter Rappl Hinrich Abken John F Bateman Kathryn SE Cheah Mats Paulsson Bent B	2012	J Bone Miner Res2012，，11：	1
8	The weal and woe of co- stimulation in the adoptive therapy of cancer with chimeric an- tigen receptor (CAR) -redirected T cells 显示文摘	Hombach AA Holzinger A Abken H	2013	Curt' Mol Med2013，13，7：	1
9	CD4 + CD7- leukemic T cells from patients with S6zary syndrome are protected from galectin-1- triggered T cell death 显示文摘	Rappl G Abken H Muche JM	2002	Leukemia2002，16，5：	1
10	TRUCKs: the fourth generation of CARs显示文摘	Markus Chmielewski Hinrich Abken	2015	Expert Opinion on Biological Therapy2015，，8：	1
11	Can combined cell and anbody-based immunotherapy outsmart tumor cell 显示文摘	Abken H Hombach A Reinhold U	1998	Immunol Today1998，19，1：	1
12	Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma显示文摘	Chmielewski M Hombach AA Abken H	2014	Immunol Rev2014，257，1：	1
13	HLA-G and MIC expression in tumors and their role in anti-tumor immunity 显示文摘	Sefiger B Abken H Ferrone S	2003	Trends Immunol2003，24，2：	1
14	An Empirical Evaluation of Value-at-Risk by Scenario Sim-ulation显示文摘	Abken Peter	2000	Journal of Derivatives2000，7，4：	1
15	Antibody-IL2 fusion proteins for tumor targeting显示文摘	Hombach AA Abken H	2012	Methods Mol Biol2012，907，：	1
16	Of CARs and TRUCKs: chimeric antigen receptor(CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma 显示文摘	Chmielewski M I-Iombach AA Abken H	2014	Immunol Rev2014，257，1：	1
17	Antibody-IL2 fusion proteins for tumor targeting显示文摘	Ombach AA Abken H	2012	Methods Mol Bio12012，907，：	1
18	Photoluminescence Study of Polycrystalline Photovoltaic CdS Thin Film Layer Grown by Close-Spaced Sublimation and Chemical Bath Deposition显示文摘	Abken A E Halliday D P Durose K		0，，06：	1
19	Combining cytokine-induced killer cells with vaccination in cancer immunotherapy显示文摘	Thanendrarajan S Nowak M Abken H	2011	Leukemia Research2011，35，：	1
20	Immortali-zation of human lymphocytes by fusion with cytoplasts oftransformed mouse L cells 显示文摘	ABKEN H JUNGFERH ALBERT W H	1986	J Cell Biol1986，103，3：	1

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