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| 1 | Dual stimuli-responsive polyurethane-based hydrogels as smart drug delivery carriers for the advanced treatment of chronic skin wounds显示文摘The design of multi-stimuli-responsive vehicles for the controlled and localized release of drugs is a challenging issue increasingly catching the attention of many research groups working on the advanced treatment of hard-to-close wounds.In this work,a thermo-and pH-responsive hydrogel(P-CHP407)was prepared from an ad hoc synthesized amphiphilic poly(ether urethane)(CHP407)exposing a significant amount of-COOH groups(8.8±0.9 nmol/g_(polymer)).The exposure of acid moieties in P-CHP407 hydrogel led to slightly lower initial gelation temperature(12.1◦C vs.14.6◦C,respectively)and gelation rate than CHP407 hydrogel,as rheologically assessed.Nanoscale hydrogel characterization by Low Field NMR(LF-NMR)spectroscopy suggested that the presence of carboxylic groups in P-CHP407 caused the formation of bigger micelles with a thicker hydrated shell than CHP407 hydrogels,as further proved by Dynamic Light Scattering analyses.In addition,P-CHP407 hydrogel showed improved capability to change its internal pH compared to CHP407 one when incubated with an alkaline buffer(pH 8)(e.g.,pH_(change_5min)=3.76 and 1.32,respectively).Moreover,LF-NMR characterization suggested a stronger alkaline-pH-induced interaction of water molecules with micelles exposing-COOH groups.Lastly,the hydrogels were found biocompatible according to ISO 10993 and able to load and release Ibuprofen:delivery kinetics of Ibuprofen was enhanced by P-CHP407 hydrogels at alkaline pH,suggesting their potential use as smart delivery systems in the treatment of chronic infected wounds. | Rossella Laurano Monica Boffito Michela Abrami Mario Grassi Alice Zoso Valeria Chiono Gianluca Ciardelli | 2021 | Bioactive Materials2021，6，9： | 3 |
| 2 | Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum显示文摘 | Abrami L Kunz B Iacovache I | 2008 | Proc Natl Acad Sci USA2008，105，14： | 1 |
| 3 | Work role ambiguity, job satisfaction, and job performance: Meta-analyses and review显示文摘 | Abramis D J | 1994 | Psychological Reports1994，75，12： | 1 |
| 4 | Transcervical Femoral Fracture A review of 195 patients treated by sliding nail-plate fixation显示文摘 | Brown JT Abrami G | | 0，，： | 1 |
| 5 | student/instructor Attitude similarity,student Ratings and Course Performance 显示文摘 | Abrami P Mizener D | 1985 | Journal of educational psychology1985，77，6： | 1 |
| 6 | Glycerol permeability of mutant aquaporin 1 and other AQP-MIP proteins:inhibition studies 显示文摘 | Abrami L Berthonaud V Deen PM | 1996 | Pflugers Arehiv1996，431，3： | 1 |
| 7 | Anthrax toxin: the long and winding road that leads to the kill 显示文摘 | Abrami L Reig N van der Goot FG | 2005 | Trends Microbiol2005，13，2： | 1 |
| 8 | Anthrax toxin: the long and winding road that leads to the kill 显示文摘 | Abrami L Reig N vander Goot FG | 2005 | Trends Microbiol2005，13，2： | 1 |
| 9 | Cross-talk between caveolae and glycosylphosphatidylinositol-rich domains显示文摘 | Abrami L Fivaz M Kobayashi T | 2001 | J Biol Chem2001，276，30： | 1 |
| 10 | 查看详情显示文摘 | Abrami L | | 0，，： | 1 |
| 11 | Transeervic, al femoral fracture: a review of 195 patients treated with sliding nail-plate fixation 显示文摘 | Brown JT Abrami G | 1964 | J Bone Joint Surg (Br)1964，46，： | 1 |
| 12 | Implementing comput er technologies:Teachers' perceptions and practices显示文摘 | Wozney L Venkatesh V Abrami P | 2006 | Jour- nal of Technology and Teacher Education2006，14，1： | 1 |
| 13 | The effects of group size and exposure time on microcomputer learning显示文摘 | Baron LJ Abrami PC | 1992 | Computers in Human Behavior1992，8，4： | 1 |
| 14 | Navigating student ratings of instruction显示文摘 | d'Apollonia S Abrami P C | | American Psycholo- gist0，52，11： | 1 |
| 15 | Anthrax toxin: the long and winding road that leads to the kill 显示文摘 | Abrami L Reig N vander Goot FG | 2005 | Trends Microbiol2005，13，2： | 1 |
| 16 | The mammoj~ra- at the SYRMEP beamline 显示文摘 | Dreossi D phy project Abrami A Arfelli F | 2008 | European Journal of Radiology2008，68，3： | 1 |
| 17 | Therapeutic Potential of Nucleic Acid-Based Drugs in Coronary Hyper- Proliferative Vascular Diseases显示文摘 | G. Grassi B. Scaggiante B. Dapas R. Farra F. Tonon G. Lamberti A. Barba S. Fiorentino N. Fiotti F. Zanconati M. Abrami M. Grassi | 2013 | Current Medicinal Chemistry2013，，28： | 1 |
| 18 | First application of computed radiology to mammography with synchrotron radiation显示文摘 | E. Quai R. Longo F. Zanconati G. Jaconelli M. Tonutti A. Abrami F. Arfelli D. Dreossi G. Tromba M. A. Cova | 2013 | La radiologia medica2013，，： | 1 |
| 19 | Adventures of a pore-forming toxin at the target cell surface 显示文摘 | Abrami L Fivaz M van der Goot F G | 2000 | Trends Microbiol2000，8，： | 1 |
| 20 | Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization 显示文摘 | GUYADER M KIYOKAWA E ABRAMI L | 2002 | J Virol2002，76，10： | 1 |
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