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| 1 | Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials显示文摘Hepatocellular carcinoma(HCC), the predominant form of primary liver cancer, is the sixth most common cancer worldwide and the third leading cause of cancerrelated death. The difficulty to diagnose early cancer stages, the aggressive behaviors of HCC, and the poor effectiveness of therapeutic treatments, represent the reasons for the quite similar deaths per year and incidence number. Considering the fact that the diagnosis of HCC typically occurs in the advanced stages of the disease when the therapeutic options have only modest efficacy, the possibility to identify early diagnostic markers could be of significant benefit. So far, a large number of biomarkers have been associated to HCC progression and aggressiveness, but many of them turned out not to be of practical utility. This is the reason why active investigations are ongoing in this field. Given the huge amount of published works aimed at the identification of HCC biomarkers, in this review we mainly focused on the data published in the last year, with particular attention to the role of(1) molecular and biochemical cellular markers;(2) micro-interfering RNAs;(3) epigenetic variations; and(4) tumor stroma. It is worth mentioning that a significant number of the HCC markers described in the present review may be utilized also as targets for novel therapeutic approaches, indicating the tight relation between diagnosis and therapy. In conclusion, we believe that integrated researches among the different lines of investigation indicated above should represent the winning strategies to identify effective HCC markers and therapeutic targets. | Bruna Scaggiante Maryam Kazemi Gabriele Pozzato Barbara Dapas Rosella Farra Mario Grassi Fabrizio Zanconati Gabriele Grassi | 2014 | World Journal of Gastroenterology2014，20，5： | 13 |
| 2 | Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the predominant form of primary liver cancer and represents the third leading cause of cancer-related death worldwide. Current available therapeutic approaches are poorly effective,especially for the advanced forms of the disease. In the last year,short double stranded RNA molecules termed small interfering RNAs(si RNAs) and micro interfering RNAs(mi RNA),emerged as interesting molecules with potential therapeutic value for HCC. The practical use of these molecules is however limited by the identification of optimal molecular targets and especially by the lack of effective and targeted HCC delivery systems. Here we focus our discussion on the most recent advances in the identification of si RNAs/mi RNAs molecular targets and on the development of suitable si RNA/mi RNAs delivery systems. | Rossella Farra Mario Grassi Gabriele Grassi Barbara Dapas | 2015 | World Journal of Gastroenterology2015，21，30： | 5 |
| 3 | Performance, structure, and mechanism of CeO 2 in HCl oxidation to Cl 2显示文摘 | Amol P. Amrute Cecilia Mondelli Maximilian Moser Gerard Novell-Leruth Núria López Dirk Rosenthal Ramzi Farra Manfred E. Schuster Detre Teschner Timm Schmidt Javier Pérez-Ramírez | 2011 | Journal of Catalysis2011，，： | 2 |
| 4 | Role of E2F1-Cyclin El-cyclin E2 circuit in human coronary smooth muscle cell proliferation and therapeutic potential of its downregulation by siRNAs显示文摘 | Dapas B Farra R Grassi M | 2009 | Mol Med2009，15，910： | 1 |
| 5 | Integronsandgene casset tes in clinical isolates of co t rimoxazo le resistant Gram negative bacteri显示文摘 | Grape M Farra A Kronvall G etal | 2005 | J Clin Microbiol Infect2005，11，3： | 1 |
| 6 | Proliferation of human primary vascular smooth muscle cells depends on serum response factor显示文摘 | Daniela Werth Gabriele Grassi Nina Konjer Barbara Dapas Rossella Farra Carlo Giansante Reinhard Kandolf Gianfranco Guarnieri Alfred Nordheim Olaf Heidenreich | 2010 | European Journal of Cell Biology2010，，2： | 1 |
| 7 | 显示文摘 | PINEDA O FARRAS J MACCARI L | 2004 | Bioorganic & Medicinal Chemistry Letters2004，19，14： | 1 |
| 8 | Ray tracing in complex media显示文摘 | Farra V | 1993 | Journal of Applied Geophysics1993，30，1： | 1 |
| 9 | Ideal hierarchical secret sharing schemes 显示文摘 | Farras O Padro C | 2012 | IEEE Transactions on Information Theory2012，58，5： | 1 |
| 10 | Polyamines inhibit lipidperoxidation in senescing oat leaves显示文摘 | BORRELL A CARBONELL L FARRAS R | 1997 | Physiol Plant1997，99，： | 1 |
| 11 | Role of outer membrane proteinOprD and penicillin-binding proteins in resistance of pseudomonasaeruginosa to imipenem and meropenem显示文摘 | Farra A Islam S Stralfors A | 2008 | Int J Antimicrob A-gents2008，31，42： | 1 |
| 12 | Improving siRNA bio - distribution and minimizing side effects 显示文摘 | Scaggiante B Dapas B Farra R | 2011 | Curt Drug Metab2011，12，1： | 1 |
| 13 | Long term antibiotic re- sistance surveillance of Gram-negative pathogens suggests that temporal trends can be used as a resistance warning system显示文摘 | Sorberg M Farra A Ransio A | 2001 | Scand J Infect Dis2001，34，5： | 1 |
| 14 | Perfluoroalkyl acids and related chemistries-toxicokinetics and modes of action显示文摘 | Andersen M.E Butenhoff J.L Chang Farra D.G | | 0，，01： | 1 |
| 15 | Inducible overexpression of oat arginine decarboxylase in transgenic tobacco plants显示文摘 | Masgrau C Altabella T Farras R | 1997 | The Plant Journal1997，11，3： | 1 |
| 16 | Long-term antibiotic resistance surveillance of Gram-negative pathogens suggests that temporal trends can be used as a resistance warning system显示文摘 | Sorberg M Farra A Ransio A | 2002 | Scand J Infect Dis2002，34，5： | 1 |
| 17 | An integrated approach to Deacon chemistry on RuO2-based catalysts 显示文摘 | Teschner D Farra R Yao L D | 2012 | Journal of Catalysis2012，285，1： | 1 |
| 18 | In situ surfacecoverage analysis of Ru02 -catalysed HC1 oxidation revealsthe entropic origin of compensation in heterogeneous cataly-sis显示文摘 | TeschnerD Novell-Leruth G Farra R | 2012 | Nature Chemistry2012，4，9： | 1 |
| 19 | Long-term antibiotic resistance surveillance of Gram- negative pathogens suggests that temporal trends can be used as a resistance warning system显示文摘 | Sorberg M Farra A | 2002 | Scand J Infect Dis2002，34，5： | 1 |
| 20 | Spray combustion characteristics and gaseous emissions of a wood derived fast pyrolysis liquid-ethanol blend in a pilot stabilized swirl burner显示文摘 | Tzanetakis T Farra N Moloodi S | 2010 | Energy & Fuels2010，24，10： | 1 |
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