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41篇 您的检索式:作者名="Adaikan"
    题名 作者 年代 出处 被引量
1Oestrogen-androgen crosstalk in the pathophysiology oferectile dysfunction显示文摘Ageing in man is associated with a decline in testosterone following changes in the hypothalamo-pituitary-testicular axis. This may offset the physiologic equilibrium between oestrogen and androgen and at some point when the ratio of free testosterone to oestradiol reaches a critical level, the oestrogenic gonadotropin suppressive effect predominates with decreased release of FSH and LH. Adding to this endocrinal complexity is the continued peripheral conversion to oestradiol through aromatisation. Although the androgen deficiency is not the sole cause for impotence in the elderly, there is a gradual decrease in nocturnal penile tumescence (NPT) and spontaneous morning erections with ageing. Despite the age related increase in oestrogen levels, the information on the pathophysiological role of the 'female hormone' in erectile dysfunction has been scanty. Together with our identification of oestrogen receptors within the penile cavernosum, we have delineated dysfunctional changes on male erection mediated by oestradiol.These findings parallel the recent concerns over environmental oestrogens on fertility declines in young men. Oestrogenic activity is also present in plants and thereby in human diet. These phytoestrogens are structurally and functionally similar to oestradiol and more potent than the environmental oestrogenic chemicals such as organochlorine and phenolic compounds. Thus in the light of growing concerns of possible compromising effects on sexuality by endogenous and environmental oestrogens, we are faced with the scientific need to delineate their role on the mechanism of male erectile pathway in health and disease for clinical correlates and prognostics.B Srilatha PG Adaikan 2003Asian Journal of Andrology2003,5,4:6
2Endocrine milieu and erectile dysfunction: is oestradio-testosterone imbalance, a risk factor in the elderly?显示文摘雌激素不对女性独占,但是在 25-70   的中等传播层次发生; pg 在男人的 ml −1 ,与 44-153   相比; pg 在女人的 ml −1 。从睾丸激素(T) 的 aromatisation 产生,雌激素被认为有许多在变老的男性反对生理的功能和进步 T 衰落与浆液 oestradiol 的相对或绝对的增加被联系(E 2) 。性公正和可勃起的机能障碍(编辑) 在老很可能由于 pathophysiological E 2-T 不平衡;改变的神经质的比率可以也向 environmental/plant 雌激素在 hyperestrogenism 或后面的暴露解释编辑的更高的发生。Balasubramanian Srilatha P Ganesan Adaikan 2011Asian Journal of Andrology2011,13,4:5
3Pharmacology of penile erection in humans显示文摘P. Ganesan Adaikan Ph.D. Shan S. Ratnam 1988Cardiovascular and Interventional Radiology1988,,4:1
4Prostaglandin 15-hydroxydehydrogenase activity in human penile corpora cavemosa and its significance in prostaglandin-mediated penile erection显示文摘 Adaikan PG Sen DK 1989J Urol1989,64,:1
5Tocolytic and toxic activity of papaya seed extract on isolated rat uterus显示文摘Adebiyi A Ganesan Adaikan P Prasad RN 2003Life Sci2003,74,5:1
6Summary of the recommendations on sexual dysfunctions in men显示文摘Montorsi F Adaikan G Becher E 2010J Sex Med2010,7,11:1
7Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction--a pilot study 显示文摘Srilatha B Adaikan P G Moore P K 2006Eur J Pharmacol2006,535,13:1
8History of herbal medicines with an insight on the pharmacological properties of Tribulus terrestris显示文摘 Gauthaman K Prasad RNV 2001Ageing Male2001,4,:1
9Pregnancy outcomes following pre- and post-implantation exposure of Sprague-dawley rats to benzyl isothiocyanate显示文摘ADEBIYI A ADAIKAN P G PRASAD R N 2004Food Chem Toxicol2004,42,5:1
10Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats显示文摘K Gauthaman P.G Adaikan R.N.V Prasad 2002Life Sciences2002,,12:1
11Sexual dysfunction related to antihypertensive agents:Results from the animal model显示文摘Srilatha B Adaikan PG Arulkumaran S 1999Int J Impot Res1999,11,:1
12Endogenous hydrogen sulfide insufficiency as a predictor of sexual dysfunction in aging rats显示文摘Srilatha B Muthulakshmi P Adaikan PGE 2012The Aging Male2012,15,3:1
13Papaya (Carica papaya) consumption is unsafe in pregnancy:fact or fable? Scientific evaluation of a common belief in some parts of Asia using a rat model显示文摘Adebiyi A Adaikan P G Prasad R 2002British Journal of Nutrition2002,88,2:1
14Effect of Tribulus ter- restris on nicotinamide adenine dinucleotide phosphate 2 diaphorase activity and androgen receptors in rats brain 显示文摘Cauthaman K Adaikan P G 2005J Ethnophannaeol2005,96,12:1
15Possible role for the novel gasotransmitter hydrogen sulfide in erectile dysfunction:A pilot study 显示文摘Srilathine B Adaikan P - G Moore P - K 2006Eur J Pharmaeol2006,535,:1
16Effects of hydrogen sulfide on erectile function and its possible mechanism(s) of action显示文摘Liaw RL Srilatha B Adaikan PG 0,,07:1
17Hydrogen sulphide : A novel en- dogenous gasotransmitter facilitates ereetile function显示文摘Srilatha B Adaikan PG Li L 2007J Sex Med2007,4,5:1
18Hydrogen sulphide:a novel endogenous gasotransmitter facilitates erectile function显示文摘Srilatha B Adaikan PG Li L 0,,5:1
19Endogenous hydrogen sulfide insufficiency as a predictor of sexual dysfunction in aging rats 显示文摘Srilatha B Muthulakshmi P Adaikan PG 2012The Aging Male2012,15,3:1
20Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction--a pi lot study显示文摘Srilatha B Adaikan P G Moore P K 2006Eur J Pharmacol2006,535,13:1
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