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13篇 您的检索式：作者名="Adam Diamond"

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		题名	作者	年代	出处	被引量
	1	Effect of storage temperature on early graft function following liver transplantation显示文摘	Morino M Adam R Diamond T	1992	Clin Transplant1992，6，2：	1
	2	Effect of extended cold ischaemia with UW solution on graft function after liver transplantation显示文摘	Adam R Bismuth H Diamond T	1992	Lancet1992，340，8832：	1
	3	Liver Resection Versus Transplantation for Hepatocellular Carcinoma in Cirrhotic Patients显示文摘	Henri Bismuth Laurence Chiche René Adam Denis Castaing Tom Diamond Ashley Dennison	1993	Annals of Surgery1993，，2：	1
	4	Effect of extended cold ischaemia wi th UW solution on graft function after liver transplantation显示文摘	Adam R Bismuth H Diamond T	1992	Lancet1992，340，：	1
	5	Estimated ultraviolet radiation doses in wetlands in six national parks显示文摘	DIAMOND S A TRENHAM P C ADAMS M J	2005	Ecosystems2005，8，：	1
	6	Effect of extended cold ischaemia with UW solution on graft function after liver transplantation显示文摘	Bismuth H Diamond T	1992	Lancet1992，340，8832：	1
	7	Liver resection versus transplantation for hcpatocellular carcinoma in cirrhotic patients显示文摘	Bismuth H Chiche L Adam R Castaing D Diamond T Dennison A		0，，：	1
	8	Effect of extended cold ischaemia with UW solution on graft function after liver transplantation显示文摘	Adam R Bismuth H Diamond T	1992	Lancet1992，340，8832：	1
	9	Effect of extended cold ischemnia with UW solution on grafe function after liver transplantation显示文摘	Adam R Bismuth H Diamond T	1992	Lancet1992，340，：	1
	10	Effect of storage temperature on early graft function following liver transplantation显示文摘	MORINO M ADAM R DIAMOND T	1992	Clin Transplant1992，6，2：	1
	11	Effect of storage temperature on early graft function folllwing liver transplantation 显示文摘	Morino M Adam R Diamond T	1992	Clin Transplant1992，6，：	1
	12	Effect of storage temperature on early graft function following liver transplantation显示文摘	Morino M Adam R Diamond T	1992	Clin Transplant1992，6，：	1
	13	Dosing strategies for de novo once-daily extended release tacrolimus in kidney transplant recipients based on CYP3A5 genotype显示文摘BACKGROUND Tacrolimus extended-release tablets have been Food and Drug Administrationapproved for use in the de novo kidney transplant population.Dosing requirements often vary for tacrolimus based on several factors including variation in metabolism based on CYP3A5 expression.Patients who express CYP3A5 often require higher dosing of immediate-release tacrolimus,but this has not been established for tacrolimus extended-release tablets in the de novo setting.AIM To obtain target trough concentrations of extended-release tacrolimus in de novo kidney transplant recipients according to CYP3A5 genotype.METHODS Single-arm,prospective,single-center,open-label,observational study(ClinicalTrials.gov:NCT037-13645).Life cycle pharma tacrolimus(LCPT)orally once daily at a starting dose of 0.13 mg/kg/day based on actual body weight.If weight is more than 120%of ideal body weight,an adjusted body weight was used.LCPT dose was adjusted to maintain tacrolimus trough concentrations of 8-10 ng/mL.Pharmacogenetic analysis of CYP3A5 genotype was performed at study conclusion.RESULTS Mean time to therapeutic tacrolimus trough concentration was longer in CYP3A5 intermediate and extensive metabolizers vs CYP3A5 non-expressers(6 d vs 13.5 d vs 4.5 d;P=0.025).Mean tacrolimus doses and weight-based doses to achieve therapeutic concentration were higher in CYP3A5 intermediate and extensive metabolizers vs CYP3A5 non-expressers(16 mg vs 16 mg vs 12 mg;P=0.010)(0.20 mg/kg vs 0.19 mg/kg vs 0.13 mg/kg;P=0.018).CYP3A5 extensive metabolizers experienced lower mean tacrolimus trough concentrations throughout the study period compared to CYP3A5 intermediate metabolizers and non-expressers(7.98 ng/mL vs 9.18 ng/mL vs 10.78 ng/mL;P=00.008).No differences were identified with regards to kidney graft function at 30-d post-transplant.Serious adverse events were reported for 13(36%)patients.CONCLUSION Expression of CYP3A5 leads to higher starting doses and incremental dosage titration of extended-release tacrolimus to achieve target trough concentrations.We suggest a higher starting dose of 0.2 mg/kg/d for CYP3A5 expressers.	Adam Diamond Sunil Karhadkar Kenneth Chavin Serban Constantinescu Kwan N.Lau Oscar Perez-Leal Kerry Mohrien Nicole Sifontis Antonio Di Carlo	2023	World Journal of Transplantation2023，13，6：	0

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