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| 1 | Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies显示文摘Gastrointestinal cancers represent a major cause of morbidity and mortality,with incomplete response to chemotherapy in the advanced stages and poor prognosis.Angiogenesis plays a crucial part in tumor growth and metastasis,with most gastrointestinal cancers depending strictly on the development of a new and devoted capillary network.Confocal laser endomicroscopy is a new technology which allows in vivo microscopic analysis of the gastrointestinal mucosa and its microvascularization during ongoing endoscopy by using topically or systemically administered contrast agents.Targeting markers of angiogenesis in association with confocal laser endomicroscopic examination(immunoendoscopy),as a future challenge,will add functional analysis to the morphological aspect of the neoplastic process.This review describes previous experience in endomicroscopic examination of the upper and lower digestive tract with emphasis on vascularization,resulting in a broad spectrum of potential clinical applications,and also preclinical research that could be translated to human studies. | Dan Ionut Gheonea Tatiana Crtnǎ Tudorel Ciurea Carmen Popescu Anca Bǎdǎrǎu Adrian Sǎftoiu | 2011 | World Journal of Gastroenterology2011，17，1： | 6 |
| 2 | Early infant male circumcision:Systematic review,risk-benefit analysis,and progress in policy显示文摘AIM To determine whether recent evidence-based United States polices on male circumcision(MC) apply to comparable Anglophone countries,Australia and New Zealand.METHODS Articles in 2005 through 2015 were retrieved from PubM ed using the keyword 'circumcision' together with 36 relevant subtopics.A further PubM ed search was performed for articles published in 2016.Searches of the EMBASE and Cochrane databases did not yield additional citable articles.Articles were assessed for quality and those rated 2+ and above according to the Scottish Intercollegiate Grading System were studied further.The most relevant andrepresentative of the topic were included.Bibliographies were examined to retrieve further key references.Randomized controlled trials,recent high quality systematic reviews or meta-analyses(level 1++ or 1+ evidence) were prioritized for inclusion.A risk-benefit analysis of articles rated for quality was performed.For efficiency and reliability,recent randomized controlled trials,metaanalyses,high quality systematic reviews and large welldesigned studies were used if available.Internet searches were conducted for other relevant information,including policies and Australian data on claims under Medicare for MC.RESULTS Evidence-based policy statements by the American Academy of Pediatrics(AAP) and the Centers for Disease Control and Prevention(CDC) support infant and later age male circumcision(MC) as a desirable public health measure.Our systematic review of relevant literature over the past decade yielded 140 journal articles that met our inclusion criteria.Together,these showed that early infant MC confers immediate and lifelong benefits by protecting against urinary tract infections having potential adverse long-term renal effects,phimosis that causes difficult and painful erections and 'ballooning' during urination,inflammatory skin conditions,inferior penile hygiene,candidiasis,various sexually transmissible infections in both sexes,genital ulcers,and penile,prostate and cervical cancer.Our risk-benefit analysis showed that benefits exceeded procedural risks,which are predominantly minor,by up to 200 to 1.We estimated that more than 1 in 2 uncircumcised males will experience an adverse foreskin-related medical condition over their lifetime.Wide-ranging evidence from surveys,physiological measurements,and the anatomical location of penile sensory receptors responsible for sexual sensation strongly and consistently suggested that MC has no detrimental effect on sexual function,sensitivity or pleasure.United States studies showed that early infant MC is cost saving.The evidence supporting early infant MC has further strengthened since the positive AAP and CDC reviews.CONCLUSION Affirmative MC policies are needed in Australia and New Zealand.Routine provision of accurate,unbiased education,and access in public hospitals,will maximize health and financial benefits. | Brian J Morris Sean E Kennedy Alex D Wodak Adrian Mindel David Golovsky Leslie Schrieber Eugenie R Lumbers David J Handelsman John B Ziegler | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 2 |
| 3 | Three-dimensional vortex organization in a high-Reynolds-number supersonic turbulent boundary layer显示文摘 | Elsinga G E Adrian R J Van Oudheusden B W | 2010 | J Fluid Mech2010，644，： | 1 |
| 4 | The role of transforming growth factor-beta (TGF- beta) during ovarian follicular development in sheep 显示文摘 | JENNIFER L J ADRIAN H B KAREN L R | 2004 | Reproductive Biology and Endocrinology2004，2，： | 1 |
| 5 | Concentrations and mass fluxes of chloroacetic acids and trifluoroacetic acid in rain and natural waters in Switzerland显示文摘 | MICHEAL B STEPHAN R M ADRIAN W | 2000 | Environ Sci Technol2000，34，： | 1 |
| 6 | Dynamic and design criteria of inertia type tree shaker 显示文摘 | Adrian P A Fridley R B | 1965 | Transactions of the ASAE1965，8，1： | 1 |
| 7 | Dynamics and design criteria of inertia type tree shakers显示文摘 | Adrian P A Fridley R B | 1965 | Transactions of the ASAE1965，8，1： | 1 |
| 8 | On-table reconstruction of comminuted fractures of the radial head 显示文摘 | Adrian B Thomas P R Christoph S | 2010 | Injury2010，41，6： | 1 |
| 9 | Three-dimensional vortex organization in a high-Reynolds number supersonic turbulent boundary layer显示文摘 | Elsinga G E Adrian R J Van Oudheusden B W | 2010 | Journal of Fluid Mechanics2010，644，： | 1 |
| 10 | Toward Predictable Repair of Regurgitant Aortic Valves显示文摘 | Gsta B Adrian C Savage R | 2008 | JACC2008，52，1： | 1 |
| 11 | A three-dimensional finite element stress analysis for tunnel placement and buttons in anterior cruciate ligament reconstructions 显示文摘 | Au G James R Adrian B | 2005 | Journal of Biomechanics2005，38，： | 1 |
| 12 | Photosynthesis as a power supply for (bio-) hydrogen production 显示文摘 | BERNDT E ADRIAN B MATTHIAS R | 2006 | Trends in Plant Science2006，11，11： | 1 |
| 13 | Plant regeneration from seedling explants of Eucalyptus grandis of Europhylla 显示文摘 | Luis P B C Adriane C M G Silvia B R C | 1999 | Plant Cell Tissue and Organ Culture1999，56，： | 1 |
| 14 | Dynamics and design criteria of inertia type tree shakers 显示文摘 | Adrian P A Fridley R B | 1965 | Transactions of the ASAE1965，8，1： | 1 |
| 15 | Dynamics and design criteria ofinertia type tree shakers显示文摘 | Adrian P A Fridley R B | 1965 | Transactions of the ASAE1965，8，1： | 1 |
| 16 | Analysis of RNA-recognition motif and RS and RGG domains:conservation in metazoan pre-mRNA splicing factors显示文摘 | EWAN B SANJAY K ADRIAN R K | | 0，，： | 1 |
| 17 | 显示文摘 | Steven R D Adrian R B Alan A | 2003 | Journal of Non-Crystal-line Solids2003，315，： | 1 |
| 18 | Formation of silica/epoxy hybrid network polymers 显示文摘 | Davis S R Adrian R B Alan A | 2003 | Journal of Non - Crystalline Solids2003，315，： | 1 |
| 19 | Nitric oxide and wound healing 显示文摘 | MAJIDA R MARIA B W ADRIAN B | 2004 | World J Surg2004，28，： | 1 |
| 20 | The role of transforming growth factor beta(TGF-beta) during ovarian follicular development in sheep显示文摘 | Jennifer L J Adrian H B Karen L R | | 0，，02： | 1 |
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