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| 1 | Ocular drug delivery systems:An overview显示文摘The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration,especially for the treatment of anterior segment diseases. Delivery of drugs to the targeted ocular tissues is restricted by various precorneal,dynamic and static ocular barriers. Also,therapeutic drug levels are not maintained for longer duration in target tissues. In the past two decades,ocular drug delivery research acceleratedly advanced towards developing a novel,safe and patient compliant formulation and drug delivery devices/techniques,which may surpass these barriers and maintain drug levels in tissues. Anterior segment drug delivery advances are witnessed by modulation of conventional topical solutions with permeation and viscosity enhancers. Also,it includes development of conventional topical formulations such as suspensions,emulsions and ointments. Various nanoformulations have also been introduced for anterior segment ocular drug delivery. On the other hand,for posterior ocular delivery,research has been immensely focused towards development of drug releasing devices and nanoformulations for treating chronic vitreo-retinal diseases. These novel devices and/or formulations may help to surpass ocular barriers and associated side effects with conventional topicaldrops. Also,these novel devices and/or formulations are easy to formulate,no/negligibly irritating,possess high precorneal residence time,sustain the drug release,and enhance ocular bioavailability of therapeutics. An update of current research advancement in ocular drug delivery necessitates and helps drug delivery scientists to modulate their think process and develop novel and safe drug delivery strategies. Current review intends to summarize the existing conventional formulations for ocular delivery and their advancements followed by current nanotechnology based formulation developments. Also,recent developments with other ocular drug delivery strategies employing in situ gels,implants,contact lens and microneedles have been discussed. | Ashaben Patel Kishore Cholkar Vibhuti Agrahari Ashim K Mitra | 2013 | World Journal of Pharmacology2013，2，2： | 18 |
| 2 | Improved dielectric and electro-optical parameters of nematic liquid crystal doped with magnetic nanoparticles显示文摘This study investigates the effect of magnetic nanoparticles(NPs) on the weakly polar nematic liquid crystal(NLC).Different parameters of dielectric data were measured for both the homeotropic and planar aligned samples as a function of frequency and temperature and the substantial changes have been noticed for the doped systems. Dielectric permittivity has been increased after the dispersion of magnetic NPs in the pure NLC. Dielectric anisotropy has also been influenced by incorporating the magnetic NPs with the NLC molecules. These results were attributed to the dipole–dipole interaction between the magnetic nanoparticles and nematic liquid crystal molecules. Electro-optical study indicated the faster rise time and fall time of the doped systems as compare to pure NLC. Threshold voltage has been calculated and found to be decreased for the doped systems. Moreover, we have also calculated the rotational viscosity and the splay elastic constant for pure and the doped systems. Both the rotational viscosity and splay elastic constant of the doped systems are found to be considerably lower than those of pure NLC. Change in these properties has been explained on the basis of molecular disturbances created by the interaction between the magnetic nanoparticle and LC director. This study reveals that the inclusion of magnetic NPs in weakly polar NLC can be useful to enhance the basic properties of the weakly polar NLC and make it a promising material for many display applications. | Geeta Yadav Govind Pathak Kaushlendra Agrahari Mahendra Kumar Mohd Sajid Khan V S Chandel Rajiv Manohar | 2019 | Chinese Physics B2019，28，3： | 2 |
| 3 | Degradation of chicken feather a poultry waste product by keratinolytic bacteria isolated from dumping site at Ghazipur poultry processing plant 显示文摘 | Agrahari S Wadhwa N | 2010 | International Journal of Poultry Science2010，9，5： | 1 |
| 4 | Inhibition of Na -K -ATPase in different tissues of freshwater fish Channa punctatus (Bloch) exposed to monocrotophos显示文摘 | Agrahari S Gopal K | 2008 | Pestic Biochem Physiol2008，92，2： | 1 |
| 5 | Biochemical alteration induced by monocrotophos in the blood plasma of fish, Channa punctatus (Bloch) 显示文摘 | AGRAHARI S PANDEY K C GOPAL K | 2007 | Pesticide Biochemistry and Physiology2007，88，3： | 1 |
| 6 | Double fetus in Fetu显示文摘 | Rai R Singh DK Agrahari D | 2011 | Indian Pediatr2011，48，11： | 1 |
| 7 | Inhibition of Na+/K+-ATPase in different tissues of freshwater fish Channa punctatus (Bloch) exposed to monocrotophos 显示文摘 | Agrahari S Gopal K | 2008 | Pesticide Bioch- emistry and Physiology2008，92，2： | 1 |
| 8 | Cytokine gene polymorphisms are associated with risk of urinary bladder cancer and recurrence after BCG immunotherapy显示文摘 | Dinesh K. Ahirwar Anita Agrahari Anil Mandhani Rama D. Mittal | 2009 | Biomarkers2009，，4： | 1 |
| 9 | Molecular iodine catalyzed selective acetylation of alcohols with vinyl acetate显示文摘 | JOHN BOSCO J W AGRAHARI A SAIKIA A K | 2006 | Tetrahedron Lett2006，47，24： | 1 |
| 10 | Managing E-Procurement Solutions Portfolio:Case Study of an Indian Steel Manufacturer显示文摘 | Pani A K Agrahari A | | 0，，2： | 1 |
| 11 | Ensuring Data Stor- age Security in Cloud Computing显示文摘 | Singh R Kumar S Agrahari S K | 2014 | International Jour- nal of Engineering and Computer Science ISSN2014，，： | 1 |
| 12 | Provenance studies on the heavy mineral placers along the coastal deposits of Odisha,eastern India显示文摘The coastal deposits along the eastern part of the Indian Peninsula are known for the high abundance of heavy minerals. The present study, as discussed here, has been undertaken along the southwestern coastal part of Odisha, India, adjoining the charnockite-migmatite zone of the Eastern Ghat Mobile Belt(EGMB). The composition of the placers along the study area is primarily controlled by the detritus from the proximal hinterland rock type(s). The weathering index has been established based on the grain morphology, major element concentration and radioelement ratios. Petrological characteristics and grain morphology of monazite, zircon, ilmenite and rutile have been presented respectively, and their implications are discussed. The provenance study of these coastal placers is based on the abundance of rare earth elements(REE) and radioactive elements in the placer sands and the rock types in the study area. The tectonic implications are based on the major element abundance of the beach sands. | Shayantani Ghosal Sudha Agrahari Debashish Sengupta | 2022 | Journal of Palaeogeography2022，11，2： | 1 |
| 13 | Isolation and characterization of feather degrading enzymes from Bacillus megateriumSN1 isolated from Ghazipur poultry waste site显示文摘 | AGRAHARI S WADHWA N | 2012 | Prikl Bioklhim Mikrobiol2012，48，2： | 1 |
| 14 | Pore size characteristics of nonwoven structures under uniaxial tensile loading显示文摘 | RAWAL A AGRAHARI S K | 2011 | Journal of Materials Science2011，46，13： | 1 |
| 15 | Application of hollow fiber membrane contactor for the removal of carbon dioxide from water under liquid-liquid extraction mode 显示文摘 | AGRAHARI G K 'dERMA V BHATTACHARYA P K | 2011 | J Membr Sci2011，375，12： | 1 |
| 16 | Pore size characteristics of nonwoven structures under uniaxial tensile loading显示文摘 | RAWAL A AGRAHARI S K | 2011 | Journal af Materials Seienee2011，46，13： | 1 |
| 17 | Fluctuations of certain biochemical constituents and markers enzymes as a consequence of monocrotophos toxicity in the edible freshwater fish, Channa punctatus显示文摘 | AGRAHARI S GOPAL K | 2009 | Pesticide Biochemistry and Physiology2009，，： | 1 |
| 18 | Biochemical Alteration Induced by Monocrotophos in the Blood Plasma of Fish, Channa punctatu ( Bloch ) 显示文摘 | AGRAHARI S PANDEY K C GOPAL K | 2007 | Pesticide Biochemistry and Physiology2007，88，3： | 1 |
| 19 | Inhibition of Na + –K + -ATPase in different tissues of freshwater fish Channa punctatus (Bloch) exposed to monocrotophos显示文摘 | Shweta Agrahari Krishna Gopal | 2008 | Pesticide Biochemistry and Physiology2008，，2： | 1 |
| 20 | The exciting potential of nanotherapy in brain-tumor targeted drug delivery approaches显示文摘Delivering therapeutics to the central nervous system(CNS) and brain-tumor has been a major challenge. The current standard treatment approaches for the brain-tumor comprise of surgical resection followed by immunotherapy, radiotherapy, and chemotherapy. However, the current treatments are limited in providing significant benefits to the patients and despite recent technological advancements; brain-tumor is still challenging to treat. Brain-tumor therapy is limited by the lack of effective and targeted strategies to deliver chemotherapeutic agents across the blood-brain barrier(BBB). The BBB is the main obstacle that must be overcome to allow compounds to reach their targets in the brain. Recent advances have boosted the nanotherapeutic approaches in providing an attractive strategy in improving the drug delivery across the BBB and into the CNS. Compared to conventional formulations, nanoformulations offer significant ad vantages in CNS drug delivery approaches. Considering the above facts, in this review, the physiological/anatomical features of the brain-tumor and the BBB are briefly discussed. The drug transport mechanisms at the BBB are outlined. The approaches to deliver chemotherapeutic drugs across the CNS into the brain-tumor using nanocarriers are summarized. In addition, the challenges that need to be addressed in nanotherapeutic approaches for their enhanced clinical application in brain-tumor therapy are discussed. | Vivek Agrahari | 2017 | Neural Regeneration Research2017，12，2： | 0 |
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