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| 1 | Impact of sodium glucose cotransporter-2 inhibitors on liver steatosis/fibrosis/inflammation and redox balance in non-alcoholic fatty liver disease显示文摘BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT2-I)are the most recently approved drugs for type 2 diabetes(T2D).Recent clinical trials of these compounds reported beneficial cardiovascular(CV)and renal outcomes.A major cause of vascular dysfunction and CV disease in diabetes is hyperglycemia associated with inflammation and oxidative stress.Pre-clinical studies demonstrated that SGLT2-I reduce glucotoxicity and promote anti-inflammatory effects by lowering oxidative stress.AIM To investigate the effects of SGLT2-I on markers of oxidative stress,inflammation,liver steatosis,and fibrosis in patients of T2D with non-alcoholic fatty liver disease(NAFLD).METHODS We referred fifty-two consecutive outpatients treated with metformin monotherapy and exhibiting poor glycemic control to our centre.We introduced the outpatients to an SGLT2-I(dapagliflozin,empagliflozin,or canagliflozin;n=26)or a different hypoglycemic drug[other glucose-lowering drugs(OTHER),n=26].We evaluated circulating interleukins and serum hydroxynonenal(HNE)-or malondialdehyde(MDA)-protein adducts,fatty liver index(FLI),NAFLD fibrosis score,aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST-to-platelet-ratio index(APRI),and fibrosis-4 on the day before(T0)and following treatment for six months(T1).We also performed transient elastography at T0 and T1.RESULTS Add-on therapy resulted in improved glycemic control and reduced fasting blood glucose in both groups.Of note,following treatment for six months,a reduction of FLI and APRI,as well as of the FibroScan result,was reported in patients treated with SGLT2-I,but not in the OTHER group;furthermore,in the SGLT2-I group,we reported lower circulating levels of interleukin(IL)-1β,IL-6,tumor necrosis factor,vascular endothelial growth factor,and monocyte chemoattractant protein-1,and higher levels of IL-4 and IL-10.We did not observe any modification in circulating interleukins in the OTHER group.Finally,serum HNE-and MDA-protein adducts decreased significantly in SGLT2-I rather than OTHER patients and correlated with liver steatosis and fibrosis scores.CONCLUSION The present data indicate that treatment with SGLT2-I in patients with T2D and NAFLD is associated with improvement of liver steatosis and fibrosis markers and circulating pro-inflammatory and redox status,more than optimizing glycemic control. | Francesco Bellanti Aurelio Lo Buglio MichałDobrakowski Aleksandra Kasperczyk Sławomir Kasperczyk Palok Aich Shivaram P Singh Gaetano Serviddio Gianluigi Vendemiale | 2022 | World Journal of Gastroenterology2022，28，26： | 3 |
| 2 | How does plasmid DNA penetrate cell membranes in artificial transformation process of Escherichia coli 显示文摘 | Panja S Aich P Jana B | 2008 | Mol Membr Biol2008，25，5： | 1 |
| 3 | Synthetic Resins ⅩⅩⅨ:synthesis and characterisation of the resins derived from 2,4-dinitrophenylhydrazone derivatives of resacetophenone furfural-su bis substituted hydroxy-aromatic compounds显示文摘 | Aich R Lenka S Nayak P L | 1994 | Polymer International1994，34，： | 1 |
| 4 | Metallic conduction through engineered DNA:DNA nanoelectronic building blocks显示文摘 | Rakitin A Aich P Papadopoulos C | 2001 | Phys Rev Lett2001，86，16： | 1 |
| 5 | Metallic conduction through engineered DNA: DNA nanoelectronic building blocks 显示文摘 | Rakitin A Aich P Papadopoulos C | 2001 | Phys Rev Lett2001，86，16： | 1 |
| 6 | Estimation of psychologi-cal stress in humans:a combination of theory and practice显示文摘 | Sood P Priyadarshini S Aich P | | 0，，5： | 1 |
| 7 | Metallic conduction through engineered DNA:DNA nanoelectronic building Blocks显示文摘 | Rakitin A Aich P Papadopoulos C | 2001 | Phys Rev Lett2001，86，： | 1 |
| 8 | Modem approaches to under-standing stress and disease susceptibility : A review with spe-cial emphasis on respiratory disease 显示文摘 | Aich P Potter AA Griebel PJ | 2009 | Journal of GeneralMedicine2009，，2： | 1 |
| 9 | Metallic conductionthrough engineered DNA: DNA nanoelectronic building blocks 显示文摘 | RAKITIN A AICH P PAPADOPOULOS C | 2001 | Physical Review Letters2001，86，36： | 1 |
| 10 | Aerobic reduction of perchlorate by bacteria isolated in Kerala, South India 显示文摘 | Shete A Mukhopadhyaya P N Acharya A Aich B A Joshi S Ghole V S | 2008 | Journal of Applied Genetics2008，49，4： | 1 |
| 11 | Modern approaches to understand- ing stress and disease susceptibility: A review with special emphasis on respiratory disease显示文摘 | Aich P Potter A A Griebel PJ | 2009 | Int J Gen Med2009，2，： | 1 |
| 12 | Metallic con-duction through engineered DNA:DNA nanoelectronic building blocks显示文摘 | Rakitin A Aich P Papadopoulos C Kobzar Y.Vedeneev | | 0，，16： | 1 |
| 13 | The role of polyamines, Na( + ) and K( + ) in the formation of triple helices between purine oligonucleotides and the promoter region of the human c- src proto - oncogene显示文摘 | Aich P Thomas TJ Lee JS | 2000 | Nucleic Acids Res2000，28，12： | 1 |
| 14 | Metallic conduction through engineered DNA:DNA nanoelectronic building blocks显示文摘 | Rakitin A Aich P Papadopoulos C | 2001 | Phys Rev Lett2001，86，16： | 1 |
| 15 | Plasma production and preliminary results From the ADITYA Upgrade tokamak显示文摘The Ohmically heated circular limiter tokamak ADITYA(R_0?=?75 cm, a?=?25 cm) has been upgraded to a tokamak named the ADITYA Upgrade(ADITYA-U) with an open divertor configuration with divertor plates. The main goal of ADITYA-U is to carry out dedicated experiments relevant for bigger fusion machines including ITER, such as the generation and control of runaway electrons, disruption prediction, and mitigation studies, along with an improvement in confinement with shaped plasma. The ADITYA tokamak was dismantled and the assembly of ADITYA-U was completed in March 2016. Integration of subsystems like data acquisition and remote operation along with plasma production and preliminary plasma characterization of ADITYA-U plasmas are presented in this paper. | r l tanna j ghosh harshita raj rohit kumar suman aich vaibhav ranjan k a jadeja k m patel s b bhatt k sathyanarayana p k chattopadhyay m n makwana k s shah c n gupta v k panchal praveenlal edappala bharat arambhadiya minsha shah vismay raulji m b chowdhuri s banerjee r manchanda d raju p k atrey umesh nagora j raval y s joisa k tahiliani s k jha m v gopalkrishana | 2018 | Plasma Science and Technology2018，20，7： | 0 |
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