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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Differential ef- fector mechanisms induced by vaccination with MUC 1 DNA in the rejection of colon carcinoma growth at ortho- topic sites and metastases显示文摘 | Sugiura D Aida S Denda-Nagai K | 2008 | Cancer science2008，99，12： | 1 |
| 3 | Effects of the Addition of Oxygenated Fuels as Additives on Combustioa Characteristics and Particle Number and Size Distribution Emissions of a TDI Diesel Engine 显示文摘 | Carmen C B Carlos M Aida D S | 2014 | Fuel2014，132，15： | 1 |
| 4 | Na+/H+ exchange inhibition by Cariporide (Hoe 642) :a new principle in cardiovascular medicine 显示文摘 | Stefan D Aida S | 1999 | Cardiovascular Drug Reviews1999，17，： | 1 |
| 5 | Pharmacological modulation and differential regulation of the cardiac gap junction proteins connexin 43 and connexin 40显示文摘 | Stefan D Lioudmila P Aida S | 2002 | Biol Cell2002，94，7： | 1 |
| 6 | Moment estimates derived from Poincare and logarithmic Sobolev inequalities显示文摘 | Aida S Stroock D W | 1994 | Math Res Lett1994，62，1： | 1 |
| 7 | Analysis of bisphenol A in natural waters by means of an optical immunosensor显示文摘 | Rodriguez-Mozaz S De AIda M L Barcel6 D | 2005 | Water Research2005，39，20： | 1 |
| 8 | Fluorescence spectroscopic prop- erties and single aggregate structures of pi-conjugated wire-type dendrimers显示文摘 | Masuo S Yoshikawa H Asahi T Masuhara H Sato T Jiang D L Aida T | 2003 | Journal of Physical Chemistry B2003，107，： | 1 |
| 9 | Simulation based analysis of two different control strategies for PMSM 显示文摘 | LINDITA D AIDA S | 2013 | International Journal of Engineering Trends and Technology2013，4，4： | 1 |
| 10 | Identifying sex-specific injury predictors as a key factor in maintaining optimal physical activity levels显示文摘BACKGROUND Optimal physical activity is known to reduce cardiovascular,respiratory and endocrine system diseases and,as a consequence,improve quality of life.An important risk factor for reinjuries during normal exercise is the initial connective tissue pathology.The variety of clinical dysplastic manifestations significantly complicate the timely diagnosis of this comorbidity.AIM To establish pathognomonic sex-specific dysplasia phenotypes that indicate a particular sensitivity to physical exertion.METHODS The study involved 117 participants with recurrent musculoskeletal injuries that occurred during normal exercise.There were 67 women(57.26%)and 50 men(42.74%),which made it possible to compare the presence of the identified signs between sexes.A validated questionnaire was used to screen their connective tissue status.RESULTS Ranking the most commonly revealed dysplasia signs depending on their clinical significance made it possible to establish pathognomonic sex-specific phenotypes that indicated a particular susceptibility to injuries.Individualized programs of optimal physical activity are necessary for men with chest deformities,flat-valgus feet,dolichostenomelia,arachnodactylia,hemorrhoids,abdominal muscle diastasis and recurrent hernias.In women,special sensitivity to physical exertion was associated with a combination of signs such as asthenic body,joint hypermobility,overly soft auricles,thin hyperelastic skin,atrophic striae,telangiectasias and varicose veins.Of particular importance were universal signs such as gothic palate,scoliosis,kyphosis,leg deformities,temporomandibular joint crunching,and moderate to high myopia.CONCLUSION Participants’connective tissue condition should be considered when designing optimal physical activity programs.Identifying the established sex-specific dysplasia phenotypes will allow timely optimization of training loads,thus reducing the risk of injury. | Maria V Sankova Vladimir N Nikolenko Marine V Oganesyan Andjela D Vovkogon Aida N Gadzhiakhmedova Tatyana S Zharikova Yury O Zharikov | 2023 | World Journal of Orthopedics2023，14，3： | 0 |
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