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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | 吸烟状况与急性缺血性脑卒中后功能结局的关系显示文摘吸烟是脑卒中的既定危险因素;然而,脑卒中前吸烟状态是否会影响急性缺血性脑卒中的临床预后尚不确定。该研究旨在阐明吸烟状态与急性缺血性脑卒中后功能预后的关系。研究者获取一项基于日本多中心医院的脑卒中登记资料,调查了2007年7-12月期间住院的10825例急性缺血性脑卒中患者,这些患者在脑卒中发作之前生活能够自理。吸烟状况分为从未吸烟者(不吸烟者),曾经吸烟者和现在吸烟者。临床结局包括3个月时功能转归不良(改良的Rankin量表评分≥2)和功能性依赖(改良的Rankin量表评分2~5)。 | 刘青(译) 刘莉(摘、审校) Matsuo R Ago T Kiyuna F Sato N Nakamura K Kuroda J Wakisaka Y Kitazono T | 2020 | 中华高血压杂志2020，28，2： | 4 |
| 4 | Laterally spreading tumors:Limitations of computed tomography colonography显示文摘AIM:To prospectively investigate the detection rate of laterally spreading tumors(LSTs)of the colorectum by computed tomography(CT)colonography(CTC).METHODS:Patients with LSTs measuring≥20 mm detected during colonoscopy were prospectively enrolled in the study.All patients underwent colonoscopy and subsequent CTC on the same day.CTC was performed using multi-detector CT without contrast in the prone and supine positions.Two radiologists blinded to the existence of LSTs read the virtual endoscopic images as well as 2-D images.LSTs were classified into granular and non-granular types based on colonoscopic appearance.RESULTS:Forty-seven pathologically proven LSTs were evaluated prospectively.Histology included adenomas in 19,mucosal cancers in 19 and T1 cancers in 9.The mean diameter of the LSTs was 35.1 mm.Twenty-eight(60%)LSTs were correctly identified by CTC,and the configuration was similar to the colonoscopic appearance in most cases.Detection rate for the granular type was significantly higher than that for the nongranular type(71%vs 31%,P=0.013).Detection rate of adenomas was significantly lower than mucosal cancers(32%vs 79%,P=0.008)and T1 cancers(32%vs 78%,P=0.042).CONCLUSION:The detection rate of LSTs by CTC,particularly the non-granular type was not acceptable.Practitioners should be aware of the relatively low detection rate when using CTC. | Kazutomo Togashi Kenichi Utano Shigeyoshi Kijima Yosuke Sato Hisanaga Horie Keijirou Sunada Alan T Lefor Hideharu Sugimoto Yoshikazu Yasuda | 2014 | World Journal of Gastroenterology2014，20，46： | 4 |
| 5 | Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis显示文摘 | Nitatori T Sato N Waguri S | 1995 | J Neurosci1995，15，： | 2 |
| 6 | A H optimal theory-based generator control system显示文摘 | Ohtsuka K Taniguchi T Sato T | 1992 | IEEE Transactions on Energy Conversion1992，7，1： | 2 |
| 7 | Spatial distribution of the source-receptor relationship of sulfur in Northeast Asia显示文摘 | Kajino M. Ueda H. Sato K. Sakurai T | 2011 | 2011 (235)2011，，235： | 2 |
| 8 | Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts显示文摘 | T Komori H Yagi S Nomura A Yamaguchi K Sasaki K Deguchi Y Shimizu R.T Bronson Y.-H Gao M Inada M Sato R Okamoto Y Kitamura S Yoshiki T Kishimoto | 1997 | Cell1997，，5： | 2 |
| 9 | Drug combinations with amoxycillin reduce selection of clarithromycin resistance during Helicobacter pylori eradication therapy显示文摘 | K Murakami T Fujioka T Okimoto R Sato M Kodama M Nasu | 2002 | International Journal of Antimicrobial Agents2002，，1： | 2 |
| 10 | 尿酸是正常高值血压发展为高血压的一个重要危险标志物显示文摘正常高值血压常发展为高血压,是一个与心血管病和脑卒中高死亡率和高发病率相关的事件。然而,正常高值血压发展成高血压的危险因素仍不清楚。研究者采用年龄(52.1±11.0)岁日本成年高血压患者3584例(2081例为男性)的资料进行前瞻性群体研究,研究对象在2004年被发现处于正常高值血压阶段,并在2009年重新进行检查。 | 黄洁 叶鹏 Kuwabara M Hisatome I Niwa K Hara S Roncal-Jimenez CA Bjornstad P Nakagawa T Andres-Hernando A Sato Y Jensen T Garcia G Rodriguez-Iturbe B Ohno M Lanaspa MA Johnson RJ | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 11 | Protective effect of taurine against renal interstitial fibrosis of rats induced by cisplatin显示文摘 | Sato S Yamate J Saito T | 2002 | Naunyn Schmiedebergs Arch Pharmacol2002，365，： | 2 |
| 12 | Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia显示文摘 | Sato K Wu T Laham RJ | 2001 | J Am Coll Cardiol2001，37，： | 2 |
| 13 | Visual deprivation stimulates the exchange of the fibrous sclera into the cartilaginous sclera in chicks 显示文摘 | Kusakari T Sato T Tokoro T | 2001 | Exp Eye Res2001，73，4： | 2 |
| 14 | Increased expression of Fas antigen on bone marrow CD+34 cells of patients with aplastic anaemia显示文摘 | Maciejewski J P Selleri C Sato T | | 0，，： | 2 |
| 15 | A case of true malignant histiocytosis: identification of histiocytic origin with use of immunohistochemical and immunocytogenetic methods 显示文摘 | Sato T Terui T Kogawa K | 2002 | Ann Hematol2002，81，5： | 2 |
| 16 | Mitochondrial Ca^2+-activated K^+ channels in cardiac myocytes: a mechanism of the cardioprotective effect and modulation by protein kinase A 显示文摘 | Sato T Saito T Saegusa N | 2005 | Circulation2005，111，2： | 1 |
| 17 | Diacylglycerol production in a packed bed bioreactor显示文摘 | WATANABE T SUGIURA M SATO M | 2005 | Process Biochem2005，40，2： | 1 |
| 18 | Regulation of human extravillous trophoblast function by membrane - boundpep tidases显示文摘 | Fujiwara H Higuchi T Sato Y | 2005 | Biochim Biophys Acta2005，1751，1： | 1 |
| 19 | Tako-tsubo-like left ventricular dysfunction with ST-segment elevation:a novel cardiac syndrome mimicking acute myocardial Infarction显示文摘 | Kurisu S Sato H Kawagoe T | 2002 | Am Heart J2002，143，： | 1 |
| 20 | TAGE ( toxic AGEs) theory in diabetic complications显示文摘 | Sato T Iwaki M Shimogaito N | 2006 | Curr Mol Med2006，6，3： | 1 |
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