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| 1 | New Japanese classifications and treatment guidelines for gastric cancer: revision concepts and major revised points显示文摘 | Takeshi Sano Takashi Aiko | 2011 | Gastric Cancer2011，，2： | 5 |
| 2 | Active treatments are a rational approach for hepatocellular carcinoma in elderly patients显示文摘AIM: To determine whether an active intervention is beneficial for the survival of elderly patients with hepa-tocellular carcinoma (HCC). METHODS: The survival of 740 patients who received various treatments for HCC between 1983 and 2011 was compared among different age groups using Cox regression analysis. Therapeutic options were principal-ly selected according to the clinical practice guidelines for HCC from the Japanese Society of Hepatology. The treatment most likely to achieve regional control capa-bility was chosen, as far as possible, in the following order: resection, radiofrequency ablation, percutaneous ethanol injection, transcatheter arterial chemoembo-lization, transarterial oily chemoembolization, hepatic arterial infusion chemotherapy, systemic chemotherapy including molecular targeting, or best supportive care.Each treatment was used alone, or in combination, with a clinical goal of striking the best balance be-tween functional hepatic reserve and the volume of the targeted area, irrespective of their age. The percent survival to life expectancy was calculated based on a Japanese national population survey. RESULTS: The median ages of the subjects during each 5-year period from 1986 were 61, 64, 67, 68 and 71 years and increased significantly with time (P<0.0001). The Child-Pugh score was comparable among younger (59 years of age or younger), middle-aged (60-79 years of age), and older (80 years of age or older) groups (P=0.34), whereas the tumor-node-metastasis stage tended to be more advanced in the younger group (P=0.060). Advanced disease was significantly more frequent in the younger group compared with the middle-aged group (P=0.010), whereas there was no difference between the middle-aged and elderly groups (P=0.75). The median sur-vival times were 2593, 2011, 1643, 1278 and 1195 d for 49 years of age or younger, 50-59 years of age, 60-69 years of age, 70-79 years of age, or 80 years of age or older age groups, respectively, whereas the me-dian percent survival to life expectancy were 13.9%, 21.9%, 24.7%, 25.7% and 37.6% for each group, respectively. The impact of age on actual survival time was significant (P=0.020) with a hazard ratio of 1.021, suggesting that a 10-year-older patient has a 1.23-fold higher risk for death, and the overall survival was the worst in the oldest group. On the other hand, when the survival benefit was evaluated on the basis of per-cent survival to life expectancy, age was again found to be a significant explanatory factor (P=0.022); how-ever, the oldest group showed the best survival among the five different age groups. The youngest group revealed the worst outcomes in this analysis, and the hazard ratio of the oldest against the youngest was 0.35 for death. The survival trends did not differ substan-tially between the survival time and percent survival tolife expectancy, when survival was compared overall or among various therapeutic interventions. CONCLUSION: These results suggest that a thera-peutic approach for HCC should not be restricted due to patient age. | Takeshi Suda Aiko Nagashima Shyunsaku Takahash Tsutomu Kanefuji Kenya Kamimura Yasushi Tamura Ma-saaki Takamura Masato Igarashi Hirokazu Kawai Satoshi Yamagiwa Minoru Nomoto Yutaka Aoyagi | 2013 | World Journal of Gastroenterology2013，19，24： | 4 |
| 3 | Minimally invasive surgery for resection of duodenal carcinoid tumors: endoscopic full-thickness resection under laparoscopic observation显示文摘 | Hironori Tsujimoto Takashi Ichikura Shigeaki Nagao Tomoki Sato Satoshi Ono Satoshi Aiko Shuichi Hiraki Yoshihisa Yaguchi Naoko Sakamoto Takemaru Tanimizu Junji Yamamoto Kazuo Hase | 2010 | Surgical Endoscopy2010，，2： | 2 |
| 4 | Preparation of Distilled and Purified Continuousvariable Entangled States 显示文摘 | HAGE BORIS SAMBLOWSKI AIKO DIGUGLIELMO JAMES | 2008 | Nature Physics2008，4，： | 1 |
| 5 | Beneficial effects of immediate enteral nutrition after esophageal cancer surgery显示文摘 | AikoS Yoshizumi Y Sugiura Y | | 0，，11： | 1 |
| 6 | The role of exosomal microRNAs;focus on clinical applications in breast cancer显示文摘Despite several advances in targeted therapies for breast cancer,breast-cancer-associated death remains high in women.This is partially due to the lack of reliable markers predicting metastatic disease or recurrence after initial therapy.Recent research into the clinical validity of circulating cancer-specific biomarkers as a“liquid biopsy”is of growing interest.Of these,exosomal microRNAs(miRNAs)are promising candidate biomarkers for clinical use in breast cancer.In addition to their diagnostic value,exosomal miRNAs play an important role in predicting clinical outcome or treatment response.In this review,it is focused on the findings concerning exosomal miRNAs in relation to disease detection,prognostic impact and therapeutic effect in breast cancer,and discuss their clinical utility. | Aiko Sueta Yutaka Yamamoto Hirotaka Iwase | 2019 | Cancer Drug Resistance2019，2，3： | 1 |
| 7 | New Japanese classifications and treatment guidelines for gastric cancer:revision concepts and major revised points显示文摘 | Sano T Aiko T | 2011 | Gastric Cancer2011，14，2： | 1 |
| 8 | Comparison between ulinastatin and gabexate mesylate for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: a prospective, randomized trial显示文摘 | Toshiharu Ueki Keisuke Otani Kenichiro Kawamoto Aiko Shimizu Naruhito Fujimura Seigo Sakaguchi Toshiyuki Matsui | 2007 | Journal of Gastroenterology2007，，2： | 1 |
| 9 | The new Japanese Classification of Gastric Carcinoma: Points to be revised显示文摘 | Takashi Aiko Mitsuru Sasako | 1998 | Gastric Cancer1998，，1： | 1 |
| 10 | Angiotensin converting enzyme-inhibitory triterpense from Ganoderma lucidum显示文摘 | Katsuaki Kitabatake Yoshinori Fujimoto | 1986 | Chem Pharm Bull1986，34，7： | 1 |
| 11 | Influences of thoracic duct blockage on early enteral nutrition for patients who underwent esophageal cancel surgery显示文摘 | Aiko S Yoshizumi Y Matsuyama T | 2003 | Jpn J Thorac Cardiovase Surg2003，51，7： | 1 |
| 12 | Formation of a TiO2 micronetwork on a UV-absorbing Si02-based gIass surface by excimer laser irradiation显示文摘 | Aiko N Yoshizo K and Hiroyuld N | 2005 | Chem Mater2005，17，26： | 1 |
| 13 | Hypothalamic hamartoma: report of two cases显示文摘 | Nishio S Fujiwara S Aiko Y | 1989 | J Neurosurg1989，70，3： | 1 |
| 14 | Structural and mechanical properties of amorphous-carbon films produced by high-flu ence metallic ion implantation into polyimide显示文摘 | Tomohiro K Aiko N Masaya I | 2002 | Surface and Coatings Technology2002，，： | 1 |
| 15 | The effects of immediate enteral feeding with a formula containing high levels of ω-3 fatty acids in patients after surgery for esophageal eancer显示文摘 | Aiko S Yoshizumi Y Tsuwano S | 2005 | JPEN J Parenter Enteral Nntr2005，29，3： | 1 |
| 16 | Reduction rate of lymph node metastasis as a significant prognostic factor in esophageal cancer patients treated with neoadiuvant chemoradiation therapy显示文摘 | Aiko S Yoshizumi Y Ishizuka T | 2007 | Diseases of Esophagus2007，20，2： | 1 |
| 17 | Structural and functional complexity of the genomic region controlling AK - Toxin biosynthesis and pathogenicity in the Japanese pear pathotype of Alternaria alternata 显示文摘 | Aiko T & Takashi T | 2000 | Molecular Plant - Microbe Interactions2000，13，9： | 1 |
| 18 | Beneficial effects of immediate enteral nutrition after esophageal cancer surgery显示文摘 | Aiko S Yoshizumi Y Sugiura Y | 2001 | Surg Today2001，31，11： | 1 |
| 19 | Emission potential of condensable suspended particulate matter from flue gas of solid waste combustion显示文摘 | Mayumi T Nakaha N Aiko H | 2008 | Powder technology2008，18，12： | 1 |
| 20 | Preparation and characterization of temperature-responsive magnetite nanoparticles conjugated with N -isopropylacrylamide-based functional copolymer显示文摘 | Hirotake Wakamatsu Kazuya Yamamoto Aiko Nakao Takao Aoyagi | 2005 | Journal of Magnetism and Magnetic Materials2005，，2： | 1 |
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