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| 1 | Diarrhoea-predominant irritable bowel syndrome distinguishable by 16S rRNA gene phylotype quantification显示文摘AIM:To study whether selected bacterial 16S ribosomal RNA(rRNA)gene phylotypes are capable of disting- uishing irritable bowel syndrome(IBS). METHODS:The faecal microbiota of twenty volunteers with IBS,subdivided into eight diarrhoea-predominant (IBS-D),eight constipation-predominant(IBS-C)and four mixed symptom-subtype(IBS-M)IBS patients,and fifteen control subjects,were analysed at three time-points with a set of fourteen quantitative real-timepolymerase chain reaction assays.All assays targeted 16S rRNA gene phylotypes putatively associated with IBS,based on 16S rRNA gene library sequence analysis. The target phylotypes were affiliated with Actinobac-teria,Bacteroidetes and Firmicutes.Eight of the target phylotypes had less than 95%similarity to cultured bacterial species according to their 16S rRNA gene sequence.The data analyses were made with repeated-measures ANCOVA-type modelling of the data and principle component analysis(PCA)with linear mixed-effects models applied to the principal component scores. RESULTS:Bacterial phylotypes Clostridium cocleatum 88%,Clostridium thermosuccinogenes 85%,Coprobacillus catenaformis 91%,Ruminococcus bromii-like, Ruminococcus torques 91%,and R.torques 93%were detected from all samples analysed.A multivariate analysis of the relative quantities of all 14 bacterial 16S rRNA gene phylotypes suggested that the intestinal microbiota of the IBS-D patients differed from other sample groups.The PCA on the first principal component(PC1),explaining 30.36%of the observed variation in the IBS-D patient group,was significantly altered from all other sample groups(IBS-D vs control, P=0.01;IBS-D vs IBS-M,P=0.00;IBS-D vs IBS-C, P=0.05).Significant differences were also observed in the levels of distinct phylotypes using relative values in proportion to the total amount of bacteria.A phy- lotype with 85%similarity to C.thermosuccinogenes was quantified in significantly different quantities among the IBS-D and control subjects(-4.08±0.90 vs -3.33±1.16,P=0.04)and IBS-D and IBS-M subjects (-4.08±0.90 vs-3.08±1.38,P=0.05).Furthermore,a phylotype with 94%similarity to R.torques was more prevalent in IBS-D patients'intestinal micro- biota than in that of control subjects(-2.43±1.49 vs -4.02±1.63,P=0.01).A phylotype with 93%simi- larity to R.torques was associated with control sam- ples when compared with IBS-M(-2.41±0.53 vs -2.92±0.56,P=0.00).Additionally,a R.bromii-like phylotype was associated with IBS-C patients in com- parison to control subjects(-1.61±1.83 vs-3.69± 2.42,P=0.01).All of the above mentioned phylotype specific alterations were independent of the effect of time. CONCLUSION:Significant phylotype level alterationsin the intestinal microbiotas of IBS patients were observed,further emphasizing the possible contribution of the gastrointestinal microbiota in IBS. | Anna Lyra Teemu Rinttil Janne Nikkil Lotta Krogius-Kurikka Kajsa Kajander Erja Malinen Jaana Mtt Laura Mkel Airi Palva | 2009 | World Journal of Gastroenterology2009，15，47： | 26 |
| 2 | Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome显示文摘AIM:To investigate the correlations between selfreported symptoms of irritable bowel syndrome(IBS) and the gastrointestinal(GI) microbiota composition.METHODS:Fecal samples were collected from a total of 44 subjects diagnosed with IBS.Their symptoms were monitored with a validated inflammatory bowel disease questionnaire adjusted for IBS patients.Thirteen quantitative real-time polymerase chain reaction assays were applied to evaluate the GI microbiota composition.Eubacteria and GI bacterial genera(Bifidobacterium,Lactobacillus and Veillonella),groups(Clostridium coccoides/Eubacterium rectale,Desulfovibrio desulfuricans) and distinct bacterial phylotypes [closest 16S rDNA sequence resemblance to species Bifidobacterium catenulatum,Clostridium cocleatum,Collinsella aerofaciens(C.aerofaciens),Coprococcus eutactus(C.eutactus),Ruminococcus torques and Streptococcus bovis ] with a suspected association with IBS were quantified.Correlations between quantities or presence/absence data of selected bacterial groups or phylotypes and various IBSrelated symptoms were investigated.RESULTS:Associations were observed between subjects' self-reported symptoms and the presence or quantities of certain GI bacteria.A Ruminococcus torques(R.torques)-like(94% similarity in 16S rRNA gene sequence) phylotype was associated with severity of bowel symptoms.Furthermore,among IBS subjects with R.torques 94% detected,the amounts of C.cocleatum 88%,C.aerofaciens-like and C.eutactus 97% phylotypes were significantly reduced.Interesting observations were also made concerning the effect of a subject's weight on GI microbiota with regard to C.aerofaciens like phylotype,Bifidobacterium spp.and Lactobacillus spp.CONCLUSION:Bacteria seemingly affecting the symptom scores are unlikely to be the underlying cause or cure of IBS,but they may serve as biomarkers of the condition. | Erja Malinen Lotta Krogius-Kurikka Janne Nikkil Airi Palva Anna Lyra Anne Jskelinen Teemu Rinttil Terttu Vilpponen-Salmela Atte Johannes von Wright | 2010 | World Journal of Gastroenterology2010，16，36： | 13 |
| 3 | Variations in seed germination ofHippophae salicifolia with different presoaking treatments显示文摘H 的成熟种子。 salicifolia ,从五起源镇定(即 Hanuman Chatti , Helang , Lata , Rambara 和 Janggal Chatti )在西方 Himalaya ,印度,与层化被对待(在为 15 , 30 和 60 天的 4 °C )并且在 GA 3的不同集中( 5 , 10 , 20 公里), KNO 3( 50 , 100 , 200 公里)并且硫脲( 50 , 100 , 200 公里)在种子萌芽决定变化的答案。结果表明从在不同预先播种的处理下面的不同起源的种子的萌芽率显著地在控制与那些相比被增加(24%30%) 。与硫脲(100 公里) 对待的种子有最高的萌芽率(76%83% 为不同种子采购原料) ,由那些列在后面(63%71% 为不同种子采购原料) 有层化的 pretreated (4 ° C, 30 天) 。GA3 处理显著地弄短吝啬的萌芽时间(MGT ) 并且改善种子发芽率。考虑实际适用性和费用有效性,硫脲(100 公里) 和层化(在 4 ° C ) 为种子萌芽的处理通过 H 的种子为集体增加被推荐。在西方 Himalaya 的村庄 / 森林托儿所的 salicifolia,印度。 | S. Airi, I.D. Bhatt A. Bhatt, R.S. Rawal, U. Dhar | 2009 | Journal of Forestry Research2009，20，1： | 4 |
| 4 | On leaf-arrangement显示文摘 | Airy H | | Proceedings of the Royal Society0，21，： | 1 |
| 5 | Significant decrease in glomerular filtration rate at5years posttransplantation in the recipients of live donor kidneys50years of age or older显示文摘 | Jain N Airy M Kumari P | 2010 | Transplant Proc2010，42，5： | 1 |
| 6 | Production of xylitol from d-xylose by recombinant Lactococcus lactis显示文摘 | Antti N Anne P Airi P | 2005 | Journal of Biotechnology2005，118，： | 1 |
| 7 | Bischofiaceae 显示文摘 | Airy Shaw HK 1965 | 1965 | Kew Bulletin1965，18，2： | 1 |
| 8 | Genetic labeling of lactobacilli in a food grade manner for strain-specific detection of industrial starlets and probiotic strains显示文摘 | EFIA MALINEN REIJA LAITINCN AIRI PALVA | 2001 | Food Microbilogy2001，，18： | 1 |
| 9 | Hydrogen peroxide activates cell death and defense gene expression in Birch显示文摘 | Riikka I P Minna-Sisko K Airi At | 2002 | Plant Physiol2002，10，130： | 1 |
| 10 | Significant decrease in glomerular filtration rate at 5 years posttransplantation in the recipients of live donor kidneys 50 years of age or older显示文摘 | Jain N Airy M Kumari P et al | 2010 | Transplant Proc2010，42，5： | 1 |
| 11 | Isolation of surface (S) layer protein carrying Lactobacillus species from porcine intestine and faeces and characterization of their adhesion properties to different host tissues显示文摘 | Miia Jakava-Viljanen Airi Palva | 2007 | Sci2007，3672，： | 1 |
| 12 | Lactobacillus surface layers and their applications显示文摘 | Silja A vall-Jaaskelinen Airi Palva | 2005 | FEMS Microbiol2005，29，： | 1 |
| 13 | Is reduced dermatoglyphic a-bridge count a reliable marker of developmental impairment inschizophrenia显示文摘 | Fearon P Lane A Airie M | 2001 | Schizophr Res2001，50，3： | 1 |
| 14 | Malignancies in patients with inflammatory bowel disease: a nationwide register study in Finland显示文摘 | Airi Jussila Lauri J Virta Eero Pukkala Martti A. F? rkkil? | 2013 | Scandinavian Journal of Gastroenterology2013，，： | 1 |
| 15 | On the Preparatory Arrangements Which will be Necessary for Efficient Observation of the Transits of Venus in the Years 1874 and 1882显示文摘 | George Biddell Airy | | Monthly Notices of the Royal Astronomical Society0，33，： | 1 |
| 16 | The Fecal Microbiota of Irritable Bowel Syndrome Patients Differs Significantly From That of Healthy Subjects显示文摘 | Anna Kassinen Lotta Krogius-Kurikka Harri M?kivuokko Teemu Rinttil? Lars Paulin Jukka Corander Erja Malinen Juha Apajalahti Airi Palva | 2007 | Gastroenterology2007，，1： | 1 |
| 17 | The pressme of grain显示文摘 | AIRY W | | 0，，： | 1 |
| 18 | Isolation of surface(S) layer protein carrying Lactobacillus species from porcine intestine and faeces and characterization of their adhesion properties to different host tissues显示文摘 | Miia J V Airi P | 2007 | Veterinary Microbiology2007，124，： | 1 |
| 19 | The pressure of grain显示文摘 | AIRY W | | Minutes of the Proceedings of the Institute of Civil Engineers0，131，： | 1 |
| 20 | High and increasing prevalence of inflammatory bowel disease in Finland with a clear North–South difference显示文摘 | Airi Jussila Lauri J. Virta Veikko Salomaa Juhani M?ki Antti Jula Martti A. F?rkkil? | 2013 | Journal of Crohn’s and Colitis2013，，7： | 1 |
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