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| 1 | Clinically relevant human temporal bone measurements using novel high-resolution cone-beam CT显示文摘Objective: To test the feasibility of measuring fine temporal bone structures using a newly established cone-beam computed tomography(CBCT)system.Materials and methods: Six formalin-fixed human cadaver temporal bones were imaged using a high-resolution CBCT system that has 900 frames and copper t aluminum filtration. Fine temporal bone structures, including those of the facial nerve canal and vestibular structures, were identified and measured.Results: The fine structures of the middle ear, including the tympanic membrane, tendon of the tensor tympani, cochleariform process of the semicanal of the tensor tympani, pyramidal eminence, footplate of the stapes, full path of the facial nerve within the temporal bone, supralabyrinthine space, semicircular canals, pathway of the subarcuate canal, and full path of the vestibular aqueduct, were clearly demonstrated. The vestibular aqueduct has a midpoint width of 0.4 ± 0.0 mm and opercular width of 0.5 ± 0.1 mm(mean ± SD). The length of the internal acoustic meatus was 10.6 ± 1.2 mm(mean ± SD), and the diameter of the internal acoustic meatus was 3.7 ± 0.3 mm(mean ± SD).Conclusion: This novel high-resolution CBCT system has potentially broad applications in the diagnosis of inner ear disease and in monitoring associated pathological changes, surgical planning, navigation for the ear surgery, and temporal bone training. | Jing Zou Jaakko Laahelma Antti Arnisalo Ilmari Pyykko | 2017 | Journal of Otology2017，12，1： | 10 |
| 2 | Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa显示文摘AIM: To analyze possible relationships between CA ⅠⅩ/CA Ⅻ and pVHL expression in normal and neoplastic colorectal mucosa.METHODS: Immunohistochemical staining of 42 tissue specimens obtained from 17 cancer patients was performed to evaluate the distribution and semi-quantitatively assess the levels of CA ⅠⅩ, CA Ⅻ and pVHL. VHL mRNAs from 14 fresh-frozen tumors was amplified by RT-PCR and subjected to sequencing. CA9 and CA12 mRNA levels were analyzed by semi-quantitative RT-PCR in comparison with VEGFas an indicator of hypoxia that uncouples the pVHL control.RESULTS: Tumor tissues were associated with a borderline increase of CA ⅠⅩ staining signal and slight but significant decrease of CA Ⅻ immunoreactivity, whereas no association was found for pVHL. Sequence analysis of RT-PCR-amplified VHL mRNAs revealed no deletions/mutations, suggesting that they were VHL-competent. We did not observe any correlation between pVHL and CA ⅠⅩ/CA Ⅻ proteins as well as between VEGF and CA9 mRNAs, but the tumor-associated changes in mRNA levels of VEGF and CA12 showed a significant inverse relationship.CONCLUSION: Our results indicate that CA9 and CA12 are regulated by different intratumoral factors and that lack of apparent relationship between the levels of CA ⅠⅩ/CA Ⅻ and pVHL cannot be fully assigned to uncoupling of negative regulatory function of pVHL by tumor hypoxia signified by induced VEGF transcription. The interplay between the functional pVHL and CA ⅠⅩ/CA Ⅻ in colorectal tumors seems rather complex and is not evident merely at the expression levels. | Antti J. Kivela Seppo Parkkila Juha Saarnio Tuomo J. Karttunen Jyrki Kivela Anna-Kaisa Parkkila Maria Bartosova Vojtech Mucha Michal Novak Abdul Waheed William S. Sly Hannu Rajaniemi Silvia Pastorekova Jaromir Pastorek | 2005 | World Journal of Gastroenterology2005，11，17： | 10 |
| 3 | PTCP Incast in Data Center Networks显示文摘In recent years,dual-homed topologies have appeared in data centers in order to offer higher aggregate bandwidth by using multiple paths simultaneously.Multipath TCP(MPTCP) has been proposed as a replacement for TCP in those topologies as it can efficiently offer improved throughput and better fairness.However,we have found that MPTCP has a problem in terms of incast collapse where the receiver suffers a drastic goodput drop when it simultaneously requests data over multiple servers.In this paper,we investigate why the goodput collapses even if MPTCP is able to actively relieve hot spots.In order to address the problem,we propose an equally-weighted congestion control algorithm for MPTCP,namely EW-MPTCP,without need for centralized control,additional infrastructure and a hardware upgrade.In our scheme,in addition to the coupled congestion control performed on each subflow of an MPTCP connection,we allow each subflow to perform an additional congestion control operation by weighting the congestion window in reverse proportion to the number of servers.The goal is to mitigate incast collapse by allowing multiple MPTCP subflows to compete fairly with a single-TCP flow at the shared bottleneck.The simulation results show that our solution mitigates the incast problem and noticeably improves goodput in data centers. | LI Ming Andrey Lukyanenko Sasu Tarkoma Antti Yla-Jaaiski | 2014 | China Communications2014，11，4： | 6 |
| 4 | Label-free visualization of cholesteatoma in the mastoid and tympanic membrane using CARS microscopy显示文摘Objective:The present study aimed to evaluate the possibility of using coherent anti-Stokes Raman spectroscopy(CARS) microscopy to determine the specific molecular morphology of cholesteatoma by detecting the natural vibrational contrast of the chemical bonds without any staining.Materials and methods:Specimens from the mastoid and tympanic membrane with and without cholesteatoma were analyzed using CARS microscopy,two-photon excited fluorescence(TPEF) microscopy,and the second harmonic generation(SHG) microscopy.Results:In cholesteatoma tissues from the mastoid,a strong resonant signal at 2845 cm^(-1) was observed by CARS,which indicated the detection of the CH_2 hydro-carbon lipid bonds that do not generate visible signals at 2940 cm^(-1) suggestive of CH_3 bonds in amino acids.A strong resonant signal at 2940 cm^(-1) appeared in an area of the same specimen,which also generated abundant signals by TPEF and SHG microscopy at 817 nm,which was suggestive of collagen.In the tympanic membrane specimen with cholesteatoma,a strong resonant signal with corrugated morphology was detected,which indicated the presence of lipids.A strong signal was detected in the tympanic membrane with chronic otitis media using TPEF/SHG at 817 nm,which indicated collagen enrichment.The CARS and TPEF/SHG images were in accordance with the histology results.Conclusion:These results suggest the need to develop a novel CARS microendoscope that can be used in combination with TPEF/SHG to distinguish cholesteatoma from inflammatory tissues. | Jing Zou Antti Isomaki Timo Hirvonen Antti Aarnisalo Jussi Jero Ilmari Pyykko | 2016 | Journal of Otology2016，11，3： | 4 |
| 5 | Protein misfolding in neurodegenerative diseases:implications and strategies显示文摘A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic collapse.Therapeutic options are currently being explored that target different steps in the production and processing of proteins implicated in neurodegenerative disease,including synthesis,chaperone-assisted folding and trafficking,and degradation via the proteasome and autophagy pathways.Other therapies,like mTOR inhibitors and activators of the heat shock response,can rebalance the entire proteostatic network.However,there are major challenges that impact the development of novel therapies,including incomplete knowledge of druggable disease targets and their mechanism of action as well as a lack of biomarkers to monitor disease progression and therapeutic response.A notable development is the creation of collaborative ecosystems that include patients,clinicians,basic and translational researchers,foundations and regulatory agencies to promote scientific rigor and clinical data to accelerate the development of therapies that prevent,reverse or delay the progression of neurodegenerative proteinopathies. | Patrick Sweeney Hyunsun Park Marc Baumann John Dunlop Judith Frydman Ron Kopito Alexander McCampbell Gabrielle Leblanc Anjli Venkateswaran Antti Nurmi Robert Hodgson | 2017 | Translational Neurodegeneration2017，6，1： | 4 |
| 6 | Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours显示文摘Carbonic anhydrases (CAs) catalyse the hydration of CO2to bicarbonate at physiological pH. This chemical interconversion is crucial since HCO3- is the substrate for several biosynthetic reactions. This review is focused on the distribution and role of CA isoenzymes in both normal and pathological gastrointestinal (GI) tract tissues. It has been known for many years that CAs are widely present in the GI tract and play important roles in several physiological functions such as production of saliva, gastric acid, bile, and pancreatic juice as well as in absorption of salt and water in intestine. New information suggests that these enzymes participate in several processes that were not envisioned earlier. Especially, the recent reports on plasma membranebound isoenzymes Ⅸ and Ⅻ have raised considerable interest since they were reported to participate in cancer invasion and spread. They are induced by tumour hypoxia and may also play a role in von Hippel-Lindau (VHL)-mediated carcinogenesis. | Antti J. Kivel Jyrki Kivel Juha Saarnio Seppo Parkkila | 2005 | World Journal of Gastroenterology2005，11，2： | 4 |
| 7 | 多层帘式涂布和一种新型压光技术显示文摘帘式涂布是一种低冲击预计量涂布方式,可用于纸和纸板的涂布。帘式涂布技术所产生的涂层为仿形涂层,因而能提供良好的纤维覆盖。在多层帘式涂布中,可以同时进行多层涂布。与单层帘式涂布相比,多层帘式涂布具有许多优点:投资成本更低、设计不同涂层性质更具灵活性、具有更大的涂布操作空间及涂层更薄等。 | Pentti Rautiainen Mika Viljanmaa Henri Vaittinen Jouni Haavisto Robert Urscheler Seppo Luomi Antti Aronen 苏艳群(译) 邝仕均(校) | 2008 | 国际造纸2008，27，5： | 3 |
| 8 | A systems biological approach to identify key transcription factors and their genomic neighborhoods in human sarcomas显示文摘Identification of genetic signatures is the main objective for many computational oncology studies. The signature usually consists of numerous genes that are differentially expressed between two clinically distinct groups of samples, such as tumor subtypes. Prospectively, many signatures have been found to generalize poorly to other datasets and, thus, have rarely been accepted into clinical use. Recognizing the limited success of traditionally generated signatures, we developed a systems biology-based framework for robust identification of key transcription factors and their genomic regulatory neighborhoods. Application of the framework to study the differences between gastrointestinal stromal tumor (GIST) and leiomyosarcoma (LMS) resulted in the identification of nine transcription factors (SRF, NKX2-5, CCDC6, LEF1, VDR, ZNF250, TRIM63, MAF, and MYC). Functional annotations of the obtained neighborhoods identified the biological processes which the key transcription factors regulate differently between the tumor types. Analyzing the differences in the expression patterns using our approach resulted in a more robust genetic signature and more biological insight into the diseases compared to a traditional genetic signature. | Antti Ylipaa Olli Yli-Harja Wei Zhang Matti Nykter | 2011 | Chinese Journal of Cancer2011，30，1： | 3 |
| 9 | Early Repolarization: Electrocardiographic Phenotypes Associated With Favorable Long-Term Outcome显示文摘 | Jani T. Tikkanen M. Juhani Junttila Olli Anttonen Aapo L. Aro Samuli Luttinen Tuomas Kerola Solomon J. Sager Harri A. Rissanen Robert J. Myerburg Antti Reunanen Heikki V. Huikuri | 2011 | Circulation2011，，23： | 3 |
| 10 | Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and Ⅻ in colorectal carcinomas显示文摘AIM To investigate expression of four alpha-carbonic anhydrases(CAs) in colorectal carcinomas(CRC) and compare the results with patients' survival.METHODS Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA Ⅱ, CA Ⅶ, CA Ⅸ, and CA Ⅻ. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients' survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients' age, and gender. Kaplan-Meier analysis and Cox regression hazard ratio model were used to analyze survival data. RESULTS CA Ⅱ and CA Ⅻ staining intensities correlated with patients' survival in that higher expression indicated poorer prognosis. In Cox regression analysis one unit increase in the CA Ⅱ intensity increased the hazard ratio to 1.19 fold(CI: 1.04-1.37, P = 0.009). A significant correlation was also found when comparing CA Ⅻ staining intensity with survival of CRC patients(HR = 1.18, 95%CI: 1.01-1.38, P = 0.036). The extent of CA Ⅻ immunostaining did not correlate to the patients' survival(P = 0.242, Kaplan-Meier analysis). A significant interaction between age group and extent of the CA Ⅱ staining was found. Increased extent of CA Ⅱ had a significant hazard ratio among patients 65 years and older(1.42, 95%CI: 1.16-1.73, P = 0.0006). No correlations were found between CA Ⅶ(intensity P = 0.566, extent P = 0.495, Kaplan-Meier analysis), or CA Ⅸ(intensity P = 0.879, extent P = 0.315, KaplanMeier analysis) immunostaining results and survival, or the other parameters. CONCLUSION The present findings indicate that CA Ⅱ and CA Ⅻ could be useful in predicting survival in CRC. | Pia Viikil? Antti J Kivel? Harri Mustonen Selja Koskensalo Abdul Waheed William S Sly Jaromir Pastorek Silvia Pastorekova Seppo Parkkila Caj Haglund | 2016 | World Journal of Gastroenterology2016，22，36： | 3 |
| 11 | Cervical artery dissection: Trauma and other potential mechanical trigger events显示文摘 | Stefan T. Engelter Caspar Grond-Ginsbach Tiina M. Metso Antti J. Metso Manja Kloss Stephanie Debette Didier Leys Armin Grau Jean Dallongeville Marie Bodenant Yves Samson Valeria Caso Alessandro Pezzini Leo H. Bonati Vincent Thijs Henrik Gensicke Juan J. M | 2013 | Neurology2013，，21： | 2 |
| 12 | Towards a comprehensive understanding of p75 neurotrophin receptor functions and interactions in the brain显示文摘The role of neurotrophins in neuronal plasticity has recently become a strong focus in neuroregeneration research field to elucidate the biological mechanisms by which these molecules modulate synapses,modify the response to injury,and alter the adaptation response.Intriguingly,the prior studies highlight the role of p75 neurotrophin receptor(p75^(NTR))in various injuries and diseases such as central nervous system injuries,Alzheimer's disease and amyotrophic lateral sclerosis.More comprehensive elucidation of the mechanisms,and therapies targeting these molecular signaling networks may allow for neuronal tissue regeneration following an injury.Due to a diverse role of the p75^(NTR)in biology,the body of evidence comprising its biological role is diffusely spread out over numerous fields.This review condenses the main evidence of p75^(NTR)for clinical applications and presents new findings from published literature how data mining approach combined with bioinformatic analyses can be utilized to gain new hypotheses in a molecular and network level. | Joel F.Ritala Seán BLyne Antti Sajanti Romuald Girard Janne Koskimäki | 2022 | Neural Regeneration Research2022，17，4： | 2 |
| 13 | Matrix metalloproteinases in the restorative proctocolectomy pouch of pediatric ulcerative colitis显示文摘AIM:To investigate matrix metalloproteinases(MMPs) and their tissue inhibitors(TIMPs) in pouch mucosa of pediatric onset ulcerative colitis(UC).METHODS:In this cross-sectional study,28 patients with pediatric onset UC underwent ileal pouch biopsy 13 years(median) after proctocolectomy.Expression of MMPs-3,-7,-8,-9,-12 and-26 and TIMPs-1,-2 and-3 in samples was examined using immunohistochemichal methods,and another biopsy was used to evaluate the grade of histological inflammation.Two investigators independently graded the immunohistochemical specimens in a semiquantitative fashion,using a scale marking staining intensity as follows:0 = less than 20 positive cells;1 = 20-50 positive cells;2 = 50-200 positive cells;3 = over 20 positive cells.Fecal calprotectin and blood inflammatory markers [serum C-reactive protein(CRP) and erythrocyte sedimentation rate] were determined during a follow-up visit to examine correlations between these markers and the expression of MMPs and TIMPs.RESULTS:Of the 28 patients with pediatric onset UC,nine had not experienced pouchitis,whereas thirteen reported a single episode,and six had recurrent pouchitis(≥ 4 episodes).At the time of the study,six patients required metronidazole.In all of the others,the most recent episode of pouchitis had occurred over one month earlier,and none were on antibiotics.Only four samples depicted no sign of inflammation,and these were all from patients who had not had pouchitis.Two samples were too small to determine the grade of inflammation,but both had suffered pouchitis,the other recurrent.No sample depicted signs of colonic metaplasia.Most pouch samples showed expression of epithelial(e) and stromal(s) MMP-3(e,n = 22;s,n = 20),MMP-7(e,n = 28;s,n = 27),MMP-12(e,n = 20;s,n =24),TIMP-2(e,n = 23;s,n = 23) and MMP-3(e,n = 23;s,n = 28) but MMP-8(e,n = 0;s,n = 1),MMP-9(e,n = 0;s,n = 9) and MMP-26(e,n = 0;s,n = 3) and TIMP-1(n = 0,both) were lacking.In samples with low grade of inflammatory activity,the epithelial MMP-3 and MMP-7 expression was increased(r =-0.614 and r =-0.472,respectively,P < 0.05 in both).MMPs and TIMPs did not correlate with the markers of inflammation,fecal calprotectin,erythrocyte sedimentation rate,or CRP,with the exception of patients with low fecal calprotectin(< 100 μg/g) in whom a higher expression of epithelial MMP-7 was found no differences in MMPor TIMP-profiles were seen in patients with a history of pouchitis compared to ones with no such episodes.Anastomosis with either straight ileoanal anastomosis or ileoanal anastomosis with J-pouch did depict differences in MMP-or TIMP-expression.CONCLUSION:The expression of MMPs pediatric UC pouch in the long-term shares characteristics with inflammatory bowel disease,but inflammation cannot be classified as a reactivation of the disease. | Laura Mkitalo Maija Piekkala Merja Ashorn Mikko Pakarinen Antti Koivusalo Riitta Karikoski Johanna Natunen Ulpu Saarialho-Kere Risto Rintala Kaija-Leena Kolho | 2012 | World Journal of Gastroenterology2012，18，30： | 2 |
| 14 | Key aspects on the behaviour of the ballast and substructure of a modern railway track:research-based practical observations in Finland显示文摘This paper presents an overview on the wide-ranging track structure studies at the Tampere University of Technology(TUT),Finland dealing with the key aspects of track geotechnics related to high-speed passenger traffic on ballasted tracks.Special attention is paid to ballast and sub-ballast,while also considering frost action,embankment stability,track stiffness,track geometry and transition zones.As a result,this paper states that understanding the ballast degradation mechanism and its consequences and assessment of its condition occupy an important role in the construction and maintenance of a smooth high-speed rail line.The choices related to building the sub-ballast also have a dramatic impact on later track deformations and maintenance needs.In cold climate,especially where seasonal frost occurs,understanding and taking into account the frost action mechanism is crucial.Especially in the maintenance and rehabilitation planning of existing tracks,high-class analyses of ground penetrating radar data and its integrated analysis with other data can yield considerable benefits. | Antti NURMIKOLU | 2012 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2012，13，11： | 2 |
| 15 | Tranexamic acid in control of primary hemorrhage during transurethral prostatectomy显示文摘 | Antti Rannikko Anssi Pétas Kimmo Taari | 2004 | Urology2004，，5： | 2 |
| 16 | 切向燃煤锅炉新型低氮燃烧器的开发显示文摘在前墙燃烧锅炉中 ,通过高温还原火焰和火焰稳定技术已可使NOX 排放量降到很低的程度 ,并已在切向燃烧中得到了应用。该技术与燃尽风系统相结合可得到更高的脱氮效率 ,同时飞灰中未燃炭的含量仍然可以保持很低。这种低氮燃烧器的脱氮效率为 5 0 %~ 80 % ,在实际运行的锅炉上使用时NOX(以NO2 计 )排放量可降低到 5 0~70mg/MJ。该技术不仅用于燃烟煤的锅炉 。 | PAULI DERNJATIN KATI SAVOLAINEN ANTTI HEINOLAIENE | 2001 | 电力环境保护2001，17，2： | 2 |
| 17 | Cancer research in the era of next-generation sequencing and big data calls for intelligent modeling显示文摘We examine the role of big data and machine learning in cancer research.We describe an example in cancer research where gene-level data from The Cancer Genome Atlas(TCGA) consortium is interpreted using a pathway-level model.As the complexity of computational models increases,their sample requirements grow exponentially.This growth stems from the fact that the number of combinations of variables grows exponentially as the number of variables increases.Thus,a large sample size is needed.The number of variables in a computational model can be reduced by incorporating biological knowledge.One particularly successful way of doing this is by using available gene regulatory,signaling,metabolic,or context-specific pathway information.We conclude that the incorporation of existing biological knowledge is essential for the progress in using big data for cancer research. | Jari Yli-Hietanen Antti Ylipää Olli Yli-Harja | 2015 | Chinese Journal of Cancer2015，34，10： | 2 |
| 18 | Neuroprotective Effects of Dexmedetomidine in the Gerbil Hippocampus after Transient Global Ischemia显示文摘 | Johanna Kuhmonen Jaroslav Pokorny Riitta Miettinen Antti Haapalinna Jukka Jolkkonen Paavo Sr. Riekkinen Juhani Sivenius | 1997 | Anesthesiology1997，，2： | 2 |
| 19 | Compositions of MgTiO3-CaTiO3 ceramics with two borosilicate glasses for LTCC technology 显示文摘 | JANTUNEN Hell RAUTIOAHO Risto UUSIMAKI Antti | 2000 | J Ear Ceram Soc2000，20，： | 1 |
| 20 | Brake squeal a literature review 显示文摘 | Papinniemi Antti Lai Joseph C S Zhao Jiye | 2002 | Applied Acoustics2002，63，4： | 1 |
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