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| 1 | Risk modification of colorectal cancer susceptibility by interleukin-8-251T>A polymorphism in Malaysians显示文摘AIM: To investigate the allele and genotype frequencies and associated risk of interleukin (IL)-8-251T>A polymorphism on colorectal cancer (CRC) susceptibility risk. METHODS: Peripheral blood samples of 255 normal controls and 255 clinically and histopathologically confirmed CRC patients were genotyped for IL-8-251T>A polymorphism employing allele-specific polymerase chain reaction. The relative association of variant allele and genotypes with CRC susceptibility risk was determined by calculating the odds ratios (ORs). Corresponding χ 2 tests on the CRC patients and controls were carried out and 95% confidence intervals (CIs) were determined using Fisher's exact test. The allele frequencies and its risk association were calculated using FAMHAP, haplotype association analysis software. RESULTS: On comparing the frequencies of genotypesof patients and controls, the homozygous variant AA was significantly higher in CRC patients (P = 0.002) compared to controls. Investigation on the association of the polymorphic genotypes with CRC susceptibility risk, showed that the homozygous variant IL-8 -251AA had a significantly increased risk with OR 3.600 (95% CI: 1.550-8.481, P = 0.001). In the case of allele frequencies, variant allele A of IL-8 -251 showed a significantly increased risk of CRC predisposition with OR 1.32 (95% CI: 1.03-1.69,P = 0.003). CONCLUSION: Variant allele and genotype of IL-8 (-251 T>A) was significantly associated with CRC susceptibility risk and could be considered as a high-risk variant for CRC predisposition. | Mohd Aminudin Mustapha Siti Nurfatimah Mohd Shahpudin Ahmad Aizat Abdul Aziz Ravindran Ankathil | 2012 | World Journal of Gastroenterology2012，18，21： | 6 |
| 2 | Inverse changes in plasma tetranectin and titin levels in patients with type 2 diabetes mellitus: a potential predictor of acute myocardial infarction?显示文摘使用 biomarkers 预言尖锐心肌的梗塞(AMI ) 的早干预将有效地减少全球心脏病发生,特别地在有类型 2 糖尿病 mellitus (T2DM ) 的高风险的病人之中。试图由检测识别潜在的 biomarkers 的这研究在没有 AMI,与那些比较跟随 AMI 的发作的 T2DM 病人在血浆蛋白质的层次变化。没有 AMI 的志愿者 T2DM 病人(控制;n=10 ) 并且有 AMI (n=10 ) 的 T2DM 病人被招募。从这些病人的血浆样品与在二个组之间的水平变化为蛋白质经由二维的胶化电气泳动(2DE ) 被评估到屏幕。胶化图象上的许多点用 Progenesis SameSpots 被分析并且使分析遭到了到假发现率(FDR ) 。有至少 1.5 褶层的统计上重要的变化的蛋白质点为集体 spectrometry (MS ) 被选择分析。由于强壮的心脏的连接, tetranectin 和 titin 被 enzymelinked immunosorbent 试金(ELISA ) 评估。在二个组之间的调整 P 值和褶层变化与显著地改变的丰富导致了 34 个蛋白质点的鉴定。在 MS 分析之上, 17 血浆蛋白质被识别:tetranectin, titin, clusterin, haptoglobin, myosin-13,锌 fnger 蛋白质 445, DNA 修理蛋白质 RAD50,浆液白朊, apolipoprotein A-IV, caspase-6, aminoacyl tRNA synthase 复杂交往的多功能的蛋白质 1, serotransferrin,松香油绑定蛋白质 4, transthyretin, alpha-1-antitrypsin, apolipoprotein A-I 和浆液淀粉的 A。在在控制和 AMI 组之间的 tetranectin 和 titin 的变化的可比较的模式用 ELISA 被证实。在摘要,在血浆的 tetranectin 和 titin 看起来仔细在 T2DM 病人之中与 AMI 的发作被联系并且能为一个心脏的事件的预言被用作潜在的 biomarkers,尽管这在未来的队研究要求确认。 | Mohd Aizat Abdul RAHIM Zubaidah Haji Abdul RAHIM Wan Azman WAN AHMAD Marina Mohd BAKRI Muhammad Dzafir ISMAI Onn Haji HASHIM | 2018 | Acta Pharmacologica Sinica2018，39，7： | 4 |
| 3 | Relationship between nickel exposure and the level of careinoem- bryonic antigen among welders in an automotive plant 显示文摘 | Chiang Lee Juan Shamsul Bahri Mohd Tamrin Syazwan Aizat Ismail | 2009 | American Journal of Applied Sciences2009，6，12： | 1 |
| 4 | Structural performance of grouted sleeve connectors with and without transverse reinforcement for precast concrete structure 显示文摘 | Aizat Alias Mohammad Amirulkhairi Zubir Khairul Anuar Shahid | 2013 | Procedia Engineering2013，53，3： | 1 |
| 5 | Structural Performance of Grouted Sleeve Connectors with and without Transverse Reinforcement for Precast Concrete Structure显示文摘 | Aizat Alias Mohammad Amirulkhairi Zubir Khairul Anuar Shahid Ahmad Baharuddin Abd RAhman | 2013 | Procedia Engineering2013，，： | 1 |
| 6 | Non-adherence to Anti-retroviral Therapy among HIV-Infected Individuals in Kyrgyzstan:Prevalence and Risk Factors,2014-2016显示文摘Backgrounds:Currently in Kyrgyzstan,ART(antiretroviral therapy)is freely provided to HIV-infected individuals on clinical grounds.Strict adherence to ART is required,it improves HIV-infected individuals’survival and quality of life,prevents HIV transmission and drug resistance.Our study aims to identify the prevalence of non-adherence to ART therapy and factors associated with it so that strategies can be designed to help maintain adherence.Methods:In a retrospective cohort study,we enrolled randomly selected 432 individuals,≥18 years of age,from among all HIV-infected individuals in Kyrgyzstan(n=950)who started ART during Jan.2014-Sep.2016.All were followed up until Dec.2016.Non-adherents were:(1)individuals lost to follow-up;(2)individuals who missed≥4.5 days of treatment per 30 days during the study period-this was established by comparing the total tablets prescribed,dates of visits for treatment,and number of tablets consumed.We reviewed the country’s HIV surveillance data and medical facilities records.We collected information on the known non-adherent risk factors,HIV clinical presentation,and details of treatment-regimens.We used logistic regression to assess the risk factors and non-adherent associations.Results:The overall non-adherence rate was 50%(214/432).In sub-group analysis,the highest rate was:61%(50/82)among alcohol abusers,60%(65/109)in those who received≥2 tablets/dose,59%(44/75)in those receiving≥2 doses/day,57%(89/155)in drug users,and 53%(144/271)in individuals aged<40 years.In multivariate analysis,≥2 tablets/dose(OR=2.1,95%CI 1.0-4.1),age<40 years(OR=1.7,95%CI 1.1-2.6),and alcohol abuse(OR=1.6,95%CI 1-2.8)were associated with non-adherence.Conclusion:The observed non-adherence rate is unacceptably high.Adherence can be improved by introducing the one tablet/day treatment regimen,establishing regular contact with those under ART,and providing them with appropriate counseling,especially those<40 years of age or with substance abuse. | Aisuluu Kubatova Aizat Arunova UKKadyrbekov Simon Ajeilat | 2020 | Journal of Health Science2020，8，1： | 0 |
| 7 | XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians显示文摘AIM: To investigate the risk association of xeroderma pigmentosum group C (XPC ) Lys939Gln polymorphism alone and in combination with cigarette smoking on colorectal cancer (CRC) predisposition. METHODS: Peripheral blood samples of 510 study subjects (255 CRC patients, 255 controls)were collected. DNA was extracted and genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism. The association between polymorphic genotype and CRC predisposition was determined using the OR and 95%CI. RESULTS: The frequency of the homozygous variant (Gln/Gln) genotype was significantly higher in cases compared with controls (16.0% vs 10.2%, P = 0.049). The Gln/Gln genotype of XPC showed a significantly higher association with the risk of CRC (OR = 1.884; 95%CI: 1.082-3.277; P = 0.025). In the case of allele frequencies, variant allele C was associated with a significantly increased risk of CRC (OR = 1.375; 95%CI: 1.050-1.802; P = 0.020). Moreover, the risk was markedly higher for those who were carriers of the Gln/Gln variant genotype and were also cigarette smokers (OR = 3.409; 95%CI: 1.061-10.949; P = 0.032). CONCLUSION: The XPC Gln/Gln genotype alone and in combination with smoking increases the risk of CRC among Malaysians. | Abdul Aziz Ahmad Aizat Mohd Shahpudin Siti Nurfatimah Mustapha Mohd Aminudin Ravindran Ankathil | 2013 | World Journal of Gastroenterology2013，19，23： | 0 |
| 8 | Source characteristics and genesis of Sb mineralization from the Au and Sb deposits of the Youjiang Basin,SW China:constraints from stibnite trace element and isotope geochemistry显示文摘The Youjiang Basin is characterized by a wide distribution of Au and Sb deposits.These deposits are mainly hosted by sedimentary rocks from Cambrian to Triassic and are structurally controlled by faults and folds.Three types of Sb mineralization can be distinguished based on geologic characteristics,economic metals,and mineral associations.The first type is dominated by Sb mineralization but contains minor or little Au,similar to the large Qinglong deposit.The second type has a spatial association with the gold deposit but formed independent Sb mineralization,reminiscent of the Badu deposit.In the third type,Sb generally formed as an accompanying element in the Carlin-type gold deposit,and stibnite occurred as euhedral crystals filling the open space and faults in the late stage of gold mineralization,analogous to the Yata deposit.Trace element concentrations and sulfur isotopic ratio of stibnite,and oxygen isotope of stibnite bearing quartz were analyzed to infer the ore source(s)for Sb mineralization and genesis.To distinguish the various types of stibnite mineralization between the deposits,Cu,Pb,and As have recognized most diagnostic,with an elevated concentration in Au and Au-Sb deposits and depleted in Sb deposit.Theδ34S isotopic composition of stibnite samples from three deposits show a wide variation,ranging from-6.6%to+17.45%.Such isotopic values may indicate the sedimentary sulfur source,introduced by fluid–rock interaction.On the other hand,fluid mixing of several end members cannot be excluded.The calculatedδ18O isotopic data of Sb-bearing quartz show the initial ore fluid in Au and Au-Sb deposits most likely have a magmatic or metamorphic origin that enriched during fluid–rock interaction,and Sb deposit characterized by initial meteoric water.From these data,we proposed that different lithologies,fluid–rock interaction,fluid pathways,and different ore fluids controlled the compositional evolution of fluids,which might be the main reason for the diversity of Au or Sb mineralization. | Aizat Zhaanbaeva Keqiang Peng Abiola Oyebamiji Kyiazbek Asilbekov | 2021 | Acta Geochimica2021，40，5： | 0 |
| 9 | A review of salivary composition changes induced by fasting and its impact on health显示文摘Human saliva is an indispensable fluid that maintains a healthy oral cavity which otherwise can lead to oral diseases(dental caries and periodontitis).In addition,salivary metabolites and microbiome profile provide early detection of systemic diseases such as cancer and obesity.Salivary diagnostic has gained popularity due to its non-invasive sampling technique.Fasting(abstinence from food or drink or both)research for weight loss and improve health is common,but studies using fasting saliva are scarce.Some metabolites in fasting saliva have been reported with interesting results,which can be enhanced by considering different confounding factors.For example,fasting saliva contains higher salivary nitrite,which is related to nitric oxide(NO).NO is a vasodilator supporting the healthy function of endothelial cells and its deficiency is connected to many diseases.The timely supply of NO through exogenous and endogenous means is highlighted and the potential advantage of fasting salivary composition changes in relation to COVID-19 infection is speculated.This review aims to provide a general discussion on the salivary composition,properties,and functions of the whole saliva,including the health benefits of fasting. | Nurul Fadhilah Kamalul Aripin NIdayu Zahid Mohd Aizat Abdul Rahim Hashim Yaacob Parvez I.Haris Zubaidah Haji AbdRahim Rauzah Hashim | 2024 | Food Science and Human Wellness2024，13，1： | 0 |
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