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| 1 | High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis显示文摘AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD ± 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS: Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity. | Aldo Spadaro Vincenza Tortorella Carmela Morace Agostino Fortiguerra Paola Composto Caterina Bonfiglio Angela Alibrandi Carmelo Luigiano Giuseppe De Caro Antonino Ajello Oscar Ferraù Maria Antonietta Freni | 2008 | World Journal of Gastroenterology2008，14，10： | 19 |
| 2 | Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits显示文摘AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable.High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC).METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD)as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, nonparametric combination test and confidence interval analysis were used for statistical analysis.RESULTS: Serum CgA above normal values (100 ng/mL)were found in 83% of HCC patients, in 48% of LC patients,in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1 046), in LC (249±369), in CH (87±94), in CRF (1 390±1 401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18).HCC patients had higher CgA values (P<0.01) than LC,CH, and IBD patients but did not differ from those with CRF or CHF. The 95% CI for the mean (250-1 289 ng/mL)in HCC patients was selected as a CgA range and the lower value of such range was assumed as cut-off.Sensitivity and specificity of CgA, calculated in relation to the cut-off in patients with cirrhosis and HCC, were respectively 61% (CI 48-73%) and 82% (CI 75-88%).Serum α-FP values were >200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between α-FP and CgA in patients with HCC and in patients with cirrhosis.CONCLUSION: When HCC is suspected and α-FP is normal or <200 ng/mL, CgA serum values represent a complementary diagnostic tool, unless kidney or heart failure is present. | Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni | 2005 | World Journal of Gastroenterology2005，11，13： | 4 |
| 3 | Meta-analysis of thyroidectomy with ultrasonic dissector versus conventional clamp and tie显示文摘 | Cirocchi R D' Ajello F Trastulli S | 2010 | World J Surg Oncol2010，8，： | 1 |
| 4 | Avian penicilliosis caused by Penicillium griseofulvum in a captive toucanet显示文摘 | Aho R Westerling B Ajello L | | 0，，28： | 1 |
| 5 | Infection Caused by Penieillium Marneffei显示文摘 | Disalvo AF Fickling AM Ajello L | 1973 | AM J Clin Pathol1973，60，2： | 1 |
| 6 | Soluble CD30 serum levels before and after treatment with alpha-interferon in patients with chronic hepatitis C 显示文摘 | Di Cesare E Spadaro A Ajello A | 2005 | Clin Chem Lab Med2005，43，8： | 1 |
| 7 | Cardiac echinococcus complicated by ventricular tachycardia显示文摘 | Marci M Ajello A Finazzo F | 2001 | Echocardiography2001，18，7： | 1 |
| 8 | Fermi LAT Detection of Pulsed Gamma-Rays from the Velalike pulsars PSR J1048-5832and PSR J2229+6114显示文摘 | Abdo A A Ackermann M Ajello M | | 0，，： | 1 |
| 9 | The First Fermi Large Area Telescope Catalog of Gammaray Pulsars显示文摘 | Abdo A A Ackermann M Ajello M | | 0，，： | 1 |
| 10 | Imported Penicilliosis Marneffei in the United States: Report of a Second Human Infection显示文摘 | Pautlcr KB Padhye AA Ajello L | 1984 | Sabouraudia1984，22，5： | 1 |
| 11 | Human penicilliosis marneffei and its relation to the bamboo rat (rhizomys pruinosus)显示文摘 | Deng ZL Yun M Ajello L | | 0，，05： | 1 |
| 12 | Robotic thyroid surgery using bilateral axillo breast-aproach: persona] inltial experience over two years显示文摘 | Kim H Y d'Ajello F Woo S U | 2012 | Minerva Chir2012，67，： | 1 |
| 13 | Meta-analysis of thyroidectmy with ultrasonic dissector versus conventional clamp and tie 显示文摘 | Cirocchi R D'Ajello F Trastulli S | 2010 | World J Surg Oncol2010，8，2： | 1 |
| 14 | Infection caused by Penicillium marneffei:description of first natural infection in man显示文摘 | Sisalvo AF Fickling AM Ajello L | 1973 | Am J Clin Pathol1973，60，2： | 1 |
| 15 | Afterload Mismatch after Mitraclip insertion for Functional Mitral Regurgitation显示文摘 | Giulio Melisurgo Silvia Ajello Federico Pappalardo Andrea Guidotti Eustachio Agricola Masanori Kawaguchi Azeem Latib Remo Daniel Covello Denti Paolo Alberto Zangrillo Ottavio Alfieri Francesco Maisano | 2014 | The American Journal of Cardiology2014，，： | 1 |
| 16 | The First Fermi Large Area Telescope Catalog of Gammaray Pub sars显示文摘 | ABDO A A ACKERMANN M AJELLO M | 2010 | ApJS2010，187，： | 1 |
| 17 | The radio/gammmray conneetion in active galactic nuclei in the era of the fermi large area teleseope显示文摘 | ACKERMANN M AJELLO M ALLAFORT A | 2011 | ApJ2011，，741： | 1 |
| 18 | Fermi LAT Detection of Pulsed Gamma-Rays from the Velalike pulsars PSRJ1048-5832 andPSRJ2229q-6114 显示文摘 | ABDO A A ACKERMANN M AJELLO M | 2009 | ApJ2009，706，： | 1 |
| 19 | Measure-ment of the Cosmic Ray e + plus e - Spectrum from20GeV to ITeV with the Fermi Large Area Telescope显示文摘 | Abdo A A Ackermann M Ajello M | 2009 | Physical Review Letters2009，102，18： | 1 |
| 20 | Cardiac echinococcus complicated by ventricular tachycardca显示文摘 | Marci M Ajello A Finazzo F | 2001 | Echocardiography2001，18，7： | 1 |
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