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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | Heuristic solutions for the multiple-choice multi-dimension knapsack problem显示文摘 | Akbar M M Manning E G Shoja G C | 2001 | Lecture Notes in Computer Science2001，2074，2： | 1 |
| 3 | Serum levels of follicl-stimulating hormone during the bovine estrous cycle 显示文摘 | Akbar A M Reichert L E Jr Dunn T G Jr | 1974 | J Anim Sci1974，39，： | 1 |
| 4 | Ursene type nortriterpene from Debregeasia salic- ifolia 显示文摘 | Akbar E Riaz M Malik A | 2001 | Fitoterapia2001，72，4： | 1 |
| 5 | Antimicrobial triterpenes from Debregeasia salicifolia 显示文摘 | Akbar E Malik A | 2002 | Nat Prod Lett2002，16，5： | 1 |
| 6 | Serum levels of follicle stimulating hormone during the bovine estrous cycle显示文摘 | Akbar A M Reichert L E Jr Dunn T G Jr | | 0，，： | 1 |
| 7 | Effect of alumina nanoparticle on the tribological performance of automotive brake friction materials显示文摘 | Habib E Akbar S Parisa J | 2014 | J Reinforced Plast Compos2014，33，2： | 1 |
| 8 | Serap-tyre- rubber replacement for aggregate and filler in concrete显示文摘 | GANJIAN E KHORAM1 M AKBAR MAGHSOUDI A | 2009 | Construe- tion and Building Materials2009，23，5： | 1 |
| 9 | Serum levels of follicle stimulating hormone during the bovinges Irouseycle 显示文摘 | Akbar A M Reichert L E Dunn T G | 1974 | J Anim Sci1974，39，： | 1 |
| 10 | Metal complexes of sulphur-nitrogen chelating agents显示文摘 | AKBAR A M LIVINGSTONE S E | 1974 | Coord Chem Rev1974，13，： | 1 |
| 11 | Cultural and other Barriers to Mo-tion Pictures Trade显示文摘 | Akbar Marvasti E Ray Canterbary | | 0，，01： | 1 |
| 12 | Epitope mapping using ribosome display in a reconstituted cell free protein synthesis system 显示文摘 | Osada E Shimizu Y Akbar B K | 2009 | J Biochem2009，145，5： | 1 |
| 13 | Serum levels of follicle-stimulating hormone during the bovine estrus cycle显示文摘 | Akbar A M Reichert L E J R Dunn T G | 1974 | J Anim Sci1974，39，2： | 1 |
| 14 | Characteristic andcomposition of Jatropha curcas oil seed from Malaysia and its potential asbiodiesel feedstock feedstock显示文摘 | Akbar E Yaakob Z Kamarudin SK Ismail M Salimon J | 2009 | Eur J Sci Res2009，，29： | 1 |
| 15 | Epitope mapping using ribosome display in a reconstituted cell-free protein synthesis system 显示文摘 | Osada E Shimizu Y Akbar BK | 2009 | J Biochem2009，145，5： | 1 |
| 16 | Photoinduced properties of nanocrystalline TiO2 sol-gel derived thin films 显示文摘 | Akbar E Mahmoud P Reza M | 2010 | Indian Acad- emy of Sciences2010，33，4： | 1 |
| 17 | Semm levels of follicl- stimttlating hormone during the boving estous cucle显示文摘 | AKBAR A M REICHERT L E DUNN T G | 1974 | Ani Sci1974，，39： | 1 |
| 18 | Effects of different levels of fish oil supplementation on performance of broilers显示文摘 | DAS G B HOSSAIN M E AKBAR M A | 2015 | Iranian Journal of Applied Animal Science2015，5，2： | 1 |
| 19 | Serum levels of follicle-stimulating hormone during the boving estous cycle显示文摘 | AKBAR A M REICHERT L E DUNN T G | 1974 | J Ani Sci1974，39，： | 1 |
| 20 | Epitope mapping using ribosome display in a reconstituted cell-free protein synthesis sys- tem 显示文摘 | Osada E Shimizu Y Akbar BK | 2009 | J Biochem2009，145，5： | 1 |
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