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| 1 | Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma显示文摘Type 2 inflammation is a complex immune response and primary mechanism for several common allergic diseases including allergic rhinitis,allergic asthma,atopic dermatitis,and chronic rhinosinusitis with nasal polyps.It is the predominant type of immune response against helminths to prevent their tissue infiltration and induce their expulsion.Recent studies suggest that epithelial barrier dysfunction contributes to the development of type 2 inflammation in asthma,which may partly explain the increasing prevalence of asthma in China and around the globe.The epithelial barrier hypothesis has recently been proposed and has received great interest from the scientific community.The development of leaky epithelial barriers leads to microbial dysbiosis and the translocation of bacteria to inter-and sub-epithelial areas and the development of epithelial tissue inflammation.Accordingly,preventing the impairment and promoting the restoration of a deteriorated airway epithelial barrier represents a promising strategy for the treatment of asthma.This review introduces the interaction between type 2 inflammation and the airway epithelial barrier in asthma,the structure and molecular composition of the airway epithelial barrier,and the assessment of epithelial barrier integrity.The role of airway epithelial barrier disruption in the pathogenesis of asthma will be discussed.In addition,the possible mechanisms underlying the airway epithelial barrier dysfunction induced by allergens and environmental pollutants,and current treatments to restore the airway epithelial barrier are reviewed. | Xiang Dong Mei Ding Jinjin Zhang Ismail Ogülür Yagiz Pat Mübeccel Akdis Yadong Gao Cezmi A.Akdis | 2022 | Chinese Medical Journal2022，，5： | 4 |
| 2 | Mechanisms of allergen-specific immunotherapy显示文摘 | Cezmi A. Akdis Mübeccel Akdis | 2010 | The Journal of Allergy and Clinical Immunology2010，，1： | 2 |
| 3 | Immune tolerance in allergy显示文摘 | Akdis M | 2009 | Curr OpinImmunol2009，21，6： | 1 |
| 4 | Thl7 cells in the big picture of immunology显示文摘 | Schmidt-Weber CB Akdis M Akdis CA | 2007 | J Allergy Clin Immunol2007，120，2： | 1 |
| 5 | Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma显示文摘 | Karagiannidis C Akdis M Holopainen P | | 0，，： | 1 |
| 6 | Diagnosis andtreatment of atopic dermatitis in children and adults: euro-pean academy of allergolgy and chinical lmmunology/amer-ican academy of allergy,asthma and lmmunology/PRAC-TALL consensus report 显示文摘 | AKDIS C A’AKDIS M’BIEBER T | 2006 | J Allergy Chlin Immunol2006，118，1： | 1 |
| 7 | Glucocortieoids upregulate FOXF3 expression eald regulatory T cells in asthma显示文摘 | Karagiannidis C Akdis M Holopainen P | 2004 | J Allergy Clin Immunol2004，114，4： | 1 |
| 8 | Interleukins, from 1 to 37, and interferon : receptors, functions, and roles in diseases 显示文摘 | Akdis M Burg|er S Crameri R | 2011 | J Al- lergy Clin Immuno12011，127，3： | 1 |
| 9 | Immunological mechanisms of allergen -specificimmunotherapy 显示文摘 | Larehe M Akdis CA Valenta R | 2006 | Nat Rev lmmunol2006，6，10： | 1 |
| 10 | Immune regulation by histamine显示文摘 | Jutel M Watanabe T Akdis M | 2002 | Curr Opindmmunol2002，14，6： | 1 |
| 11 | T regulatory cells and their counterparts:masters of immune regulation显示文摘 | Ozdemir C Akdis M Akdis CA | 2009 | Clin Exp Allergy2009，39，5： | 1 |
| 12 | Mechanisms of subcutane- ous allergen immunotherapy 显示文摘 | Soyer OU Akdis M Akdis CA | 2011 | Immunol Allergy Clin North Am2011，31，2： | 1 |
| 13 | Human NKI and NK2 subsets determined by purification of IFN - γ - secreting and IFN - γ - nonsecreting NK cells 显示文摘 | Deniz G Akdis M Aktas E | 2002 | Eur J Immunol2002，32，： | 1 |
| 14 | Bacillus Calmette-Guerin, Mycobacterium bovis, as an immunomodulator in atopic diseases 显示文摘 | Barlan I Bahceciler NN Akdis M | 2006 | Immunol Allergy Clin North Am2006，26，2： | 1 |
| 15 | T regulatory cells in allergy : novelconcepts in the pathogenesis, prevention, and treatment of allergicdiseases显示文摘 | Akdis M Blaser K Akdis CA | 2005 | J Allergy Clin Immunol2005，116，5： | 1 |
| 16 | Glu- cocorficoids upregulate FoxP3 expression and regulatory T cells in asthma 显示文摘 | Karagiannidis C Akdis M Holopainen P | 2004 | J Allergy Clin Immunol2004，114，6： | 1 |
| 17 | Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells显示文摘 | Akdis M Verhagen J Taylor A | 2004 | J Exp Med2004，199，11： | 1 |
| 18 | T regulatory cells in allergy and health:a question of allergen specificity and balance显示文摘 | Taylor A Verhagen J Akdis CA Akdis M | 2004 | Int Arch Allergy Immunol2004，135，： | 1 |
| 19 | New targets for immune modulation in asthma显示文摘 | van de Veen W Akdis M | 2014 | Curr Treat Options Allergy2014，1，2： | 1 |
| 20 | Absence of T-regulatory cell expression and function in atopic dermatitis skin显示文摘 | Verhagen J Akdis M Traidl-Hoffmann C | 2006 | J Allergy Clin Immunol2006，117，1： | 1 |
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