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| 1 | Factors associated with time to laparoscopic cholecystectomy for acute cholecystitis显示文摘AIM: To determine patient and process of care factors associated with performance of timely laparoscopic cholecystectomy for acute cholecystitis. METHODS: A retrospective medical record review of 88 consecutive patients with acute cholecystitis was conducted. Data collected included demographic data, co-morbidities, symptoms and physical findings at presentation, laboratory and radiological investigations, length of stay, complications, and admission service (medical or surgical). Patients not undergoing cholecystectomy during this hospitalization were excluded from analysis. Hierarchical generalized linear models were constructed to assess the association of pre-operative diagnostic procedures, presenting signs, and admitting service with time to surgery.RESULTS: Seventy cases met inclusion and exclusion criteria, among which 12 were admitted to the medical service and 58 to the surgical service. Mean ± SD time to surgery was 39.3 ± 43 h, with 87% of operations performed within 72 h of hospital arrival. In the adjusted models, longer time to surgery was associated with number of diagnostic studies and endoscopic retrograde cholangio-pancreatography (ERCP, P = 0.01) as well with admission to medical service without adjustment for ERCP (P < 0.05). Patients undergoing both magnetic resonance cholangiopancreatography (MRCP) and computed tomography (CT) scans experienced the longest waits for surgery. Patients admitted to the surgical versus medical service underwent surgery earlier (30.4 ± 34.9 vs 82.7 ± 55.1 h, P < 0.01), had less post-operative complications (12% vs 58%, P < 0.01), and shorter length of stay (4.3 ± 3.4 vs 8.1 ± 5.2 d, P < 0.01).CONCLUSION: Admission to the medical service and performance of numerous diagnostic procedures, ERCP, or MRCP combined with CT scan were associated with longer time to surgery. Expeditious performance of ERCP and MRCP and admission of medically stable patients with suspected cholecystitis to the surgical service to speed up time to surgery should be considered. | Chris N Daniak David Peretz Jonathan M Fine Yun Wang Alan K Meinke William B Hale | 2008 | World Journal of Gastroenterology2008，14，7： | 13 |
| 2 | Crafting authenticity: The validation of identity in self-taught art显示文摘 | Gary Alan Fine | 2003 | Theory and Society2003，，2： | 1 |
| 3 | A proposed process for the fine divided coal by flash roasting and magnetic separation 显示文摘 | ALAN FINE H MICHAEL LOWRY LESLIE F POWER | 1976 | IEEE Transaction on magnetics1976，12，5： | 1 |
| 4 | 小鼠眼角膜上皮细胞中IL-1β对Fas配体的表达调控研究显示文摘Fas配体(Fas Ligand,FasL)在多种不同的上皮细胞中均见表达,在炎症反应中诱导Fas阳性免疫细胞凋亡以保护组织.为了研究眼角膜炎症反应过程与Fas配体之间的关系,本研究检测了在眼角膜上皮细胞中IL-1β对FasL的表达翻译水平以及细胞毒性的影响,明确了在眼角膜上皮细胞中IL-1β抑制FasL的表达以及蛋白翻译,FasL的启动子活性受到IL-1β作用浓度的影响,两者呈相关性表现,发现IL-1β阻断由FasL诱导Fas阳性细胞对于眼角膜上皮细胞的细胞毒性作用.这些结果表明,眼角膜上皮细胞FasL受IL-1β的调控. | 张杰 杨克 谭德勇 曾军英 Alan Fine | 2007 | 科学通报2007，52，16： | 1 |
| 5 | Primary Medical Management of Recurrent Aggressive Angiomyxoma of the Vulva with a Gonadotropin-Releasing Hormone Agonist显示文摘 | Bruce A. Fine Alan K. Munoz Craig E. Litz David M. Gershenson | 2001 | Gynecologic Oncology2001，，1： | 1 |
| 6 | Crafting authenticity: The validation of identity in self-taught art显示文摘 | Gary Alan Fine | 2003 | Theory and Society2003，，2： | 1 |
| 7 | IL-1β regulates the mouse Fas ligand expression in corneal endothelial cells显示文摘Constitutively expressed Fas ligand (FasL) in several distinct epithelial cell types appears to protect tissues by inducing apoptosis of Fas+ immune cells during inflammatory reactions. To study the rela-tionship of FasL and inflammation process in cornea,we examined the effects of inflammatory cytokine IL-1β on the FasL production,expression and cytotoxic function in corneal endothelial cells. In this paper,we demonstrate that IL-1β inhibits the FasL production and expression in corneal endothelial cells. The promoter activities of FasL in these cells are reduced by IL-1β in a dose-dependent manner. Finally,we also find that IL-1β block the cytotoxic effects of FasL derived from corneal endothelial cells to the Fas+ target cells. These data support the view that FasL derived from corneal endothelial cells modulate inflammation within cornea. | ZHANG Jie Yang Ke TAN DeYong ZENG JunYing Alan FINE | 2007 | Chinese Science Bulletin2007，52，16： | 0 |
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