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| 1 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 2 | Finite extinction time for solutions of nonlinear parabolic equations显示文摘 | ALAN V L | 1993 | Nonlinear Aanlysis1993，21，： | 1 |
| 3 | Pilot-scale subcritical water remediation of polycyclic aromatic hydrocarbon and pesticide-contaminated soil显示文摘 | LAGADEC A J M DAVID J M ALAN V L | 2000 | Environ Sci Technol2000，34，： | 1 |
| 4 | Betalain,acid ascorbic,phenolic contents and antioxidant properties of purple,red,yellow and white cactus pears显示文摘 | SUMAYA M M T CRUZ J S MADRIGAL S E GARCíA P CARIO C J CRUZ C R VALADEZ V MARTINEZ C C L ALANíS G E | 2011 | International Journal of Molecular Sciences2011，12，10： | 1 |
| 5 | Intensive outpatient comprehensive behavioral intervention for tics: A case series显示文摘Recent randomized clinical trials have established the efficacy of Comprehensive Behavioral Intervention for Tics(CBIT) in treating children and adults with Tourette syndrome and persistent tic disorders. However, the standard CBIT protocol uses a weekly outpatient treatment format(i.e., 8 sessions over 10 wk), which may be inconvenient or impractical for some patients, particularly patients, who are required to travel long distances in order to receive care. In contrast, an intensive outpatient program may increase accessibility to evidence-based behavioral treatments for Tourette syndrome and other persistent tic disorders by eliminating the necessity of repeated travel. This case series evaluated the use of an intensive outpatient program CBIT(IOP CBIT) for the treatment of 2 preadolescent males(ages 10 and 14 years) with Tourette syndrome. The IOP CBIT treatment protocol included several hours of daily treatment over a 4-d period. Both children evi-denced notable reductions in their tics and maintained treatment gains at follow-up. Moreover, both patients and their parents expressed treatment satisfaction with the IOP CBIT format. This case series addresses an important research gap in the behavioral treatment of tic disorders literature. The patients' treatment outcomes indicate that IOP CBIT is a promising treatment that warrants more systematic investigation. | Tabatha H Blount Ann-Louise T Lockhart Rocio V Garcia Jeslina J Raj Alan L Peterson | 2014 | World Journal of Clinical Cases2014，2，10： | 1 |
| 6 | The erosion-corrosion behavior of protective coatings显示文摘 | Alan V L | 1988 | Surfaceand Coatings Technology,1988，36，10： | 1 |
| 7 | Characterization of indoor-outdoor aerosol concentration relationships during the Fresno PM exposure studies 显示文摘 | Alan F V Anne W R Rhilip A L | 2001 | Aerosol Science & Technology2001，34，1： | 1 |
| 8 | Electronic connection to the interior of a mesoporous insulator with nanowires of crystalline RuO2 显示文摘 | Ryan Joseph V Berry Alan D Anderson Michele L | 2000 | Nature2000，406，： | 1 |
| 9 | Targeted disruption of the α1,3-galactosytransferase gene in cloned pigs显示文摘 | Todd D V Jeremy B Shu-Hung Chen Carol J P Suyapa B Jeff A M Peter M J Kenneth J M Ashley E Lamborn Jamie L Cowell-Lucero Kevin D W Alan C Irina A P David L A | 2002 | Nat Biotechnology2002，20，3： | 1 |
| 10 | Characterization of Indoor- Outdoor Aerosol Concentration Relationships during the Fresno PM Exposure Studies显示文摘 | Alan F V Anne W R Philip A L | 2001 | Aerosol Science & Technology2001，34，1： | 1 |
| 11 | Arabidopsis and Nicotiana antho-cyanin production activated by maize regulator R and C1 显示文摘 | Alan M L Walbot V Davis R W | 1992 | Science1992，，258： | 1 |
| 12 | Heart Disease and Stroke Statistics-- 2011 Update: A Report From the American Heart Association显示文摘 | V e ronique L Roger Alan S | 2011 | Circulation2011，，4： | 1 |
| 13 | The Importance of Phase in Signals显示文摘 | Alan V O Jae S L | 1981 | Proceedings of the IEEE1981，69，5： | 1 |
| 14 | Erosion of Hard Material Coating Systems显示文摘 | BUQLAN W | 1988 | Wear1988，121，： | 1 |
| 15 | Informed consent for an- esthesia~a review of practice and strategies for optimizing the con sent proeess显示文摘 | ALAN R T MAGNUS K T TERRI V L | 2014 | Can J Anesth2014，61，9： | 1 |
| 16 | The importance of phase in signals显示文摘 | Alan V O Jae S L | 1981 | Proceedings of the IEEE1981，69，5： | 1 |
| 17 | Microchip atmospheric pressure photoionization for analysis of petroleum by fourier transform ion cyclotron resonance mass spectrometry显示文摘 | HAAPALA M PURCELL J M SAARELA V FRANSSILA S RODGERS R P HENDRICKSON C L MARSHALL ALAN G KOSTIAINEN R | 2009 | Anal Chem2009，81，7： | 1 |
| 18 | A necessary and sufficient condition for existence of large solutions to semilinear elliptic equations显示文摘 | Alan V L | 1999 | J Math Anal Appl1999，240，1： | 1 |
| 19 | Breaks in lithology: Interpretation problems when handing 2D structures with a 1D approximation 显示文摘 | Alan Y L James M Andrea V | 2010 | Geophysics2010，70，4： | 1 |
| 20 | E-terases and esfenvalerate resistance in Australian Helicoverpa armigera(Hubner) Lepidoptera: Noctuidae显示文摘 | Gunning Robin V Moores Graham D Devonshire Alan L | 1996 | Pesticide Biochemistry and Physiology1996，54，1： | 1 |
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