|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 2 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 4 |
| 3 | Leitlinien für den Gebrauch von Ultraschallkontrastmitteln - Januar 2004显示文摘 | T Albrecht M Blomley L Bolondi M Claudon J.-M Correas D Cosgrove L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani L Solbiati L Thorelius F Tranquart H Weskott T Whittingham | 2004 | Ultraschall in Med2004，，04： | 3 |
| 4 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D'Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 3 |
| 5 | Predictive microbial biochemistry-from molecular fossils to procaryotic membranes显示文摘 | Ourisson G Albrecht P Rohmer M | 1982 | Trends in Biochemical Sciences1982，7，： | 1 |
| 6 | Remote ischemic preconditioning regulates HIF-1α levels, apoptosis and inflammation in heart tissue of cardiosurgical patients: a pilot experimental study显示文摘 | Albrecht M Zitta K Bein B | 2013 | Basic Res Cardiol2013，108，1： | 1 |
| 7 | EFSUMB Study Group Guide lines for the use of contrast agent sinultrasound显示文摘 | Albrecht T Blomley M Bolondi L | 2004 | Ultraschall Med2004，25，： | 1 |
| 8 | TheV -TempTM Economizer System and Method for SCRTemperature Control显示文摘 | M J ALBRECHT J T BUCKLER’S A SCAVUZZO | 2011 | Technical Paper2011，，3： | 1 |
| 9 | Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells 显示文摘 | ALBRECHT M JIANG W KUMI DIAKA J | 2004 | Journal of Medicinal Food2004，7，3： | 1 |
| 10 | Plasma Resonance Enhancement of Raman Scattering by Pyridine Adsorbed on Silver or Gold Sol Particles of Size Comparable to the Excitation Wavelength显示文摘 | CREIGHTON J A BLATCHFORD C G ALBRECHT M G | 1979 | J Chem Soc1979，75，： | 1 |
| 11 | Guideline for the use of contrast agents显示文摘 | Albrecht T Blomley M Bolondi L | 2004 | J Ultrasound Med2004，25，： | 1 |
| 12 | Saceharemyees boulardii in the prevention of antibiotic - associated diarrhoea in children : a ran- domized double- blind placebo- contwlled trial显示文摘 | Kotowska M Albrecht P Szajewska H | 2005 | Aliment Phar- maeol Ther2005，21，5： | 1 |
| 13 | Imprinted ex-pression of the murine Angelman syndrome gene,Ube3a,in hippocampaland Purkinje neurons显示文摘 | ALBRECHT U SUTCLIFFE J S CATTANACH B M | 1997 | Nat Genet1997，17，： | 1 |
| 14 | Acquired neuromyoniaand peripheral neuropathy in a patient with Hodgkin,s disease 显示文摘 | Lahrmann H Albrecht G Drlicek M | 2001 | Muscle Nerve2001，24，： | 1 |
| 15 | 1713-Estmdiol attenuates hypoxic pulmonary hypertension via estrogen receptor-mediated effects 显示文摘 | iahm T Albrecht M Fisher AJ | 2012 | Am J Respir Crit Care Med2012，185，9： | 1 |
| 16 | Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation,apoptosis and remodeling显示文摘 | Meybohm P Gruenewald M Albrecht M | | 0，，10： | 1 |
| 17 | Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea in children: a randomized double-blind placebo-controlled trial 显示文摘 | Kotowska M Albrecht P Szajewska H | 2005 | Aliment Pharmacol Ther2005，21，5： | 1 |
| 18 | Extracellular concentrations of taurine,glutamate, and aspartate in the eerebralcortex of rats at the asymptomatic stage of thioaeetamide-induced hepatic failure:modulation by ketamine anesthesia显示文摘 | ALBRECHT J HILGIER W ZIELINSKA M | 2000 | Neurochem Res2000，25，11： | 1 |
| 19 | Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘 | M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia | 2008 | Ultraschall in Med2008，，01： | 1 |
| 20 | Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS)-Update 2008显示文摘 | Glaudon M Cosgrove D Albrecht T | | 0，，01： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员