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| 1 | Drain amylase value as an early predictor of pancreatic fistula after cephalic duodenopancreatectomy显示文摘AIM:To determine predictors of clinically relevant pancreatic fistulas(CRPF)by measuring drain fluid amylase(DFA)in the early postoperative period.METHODS:This prospective clinical study included382 patients with periampullary tumors that were surgically resected at our department between March 2005and October 2012.A cephalic duodenopancreatectomy (DP)was performed on all patients.Two closed suction drains were placed at the end of the surgery.The highest postoperative DFA value was recorded and analyzed during the first three postoperative days and on subsequent days if the drains were kept longer.Pancreatic fistula(PF)was classified according to the International Study Group of Pancreatic Fistula(ISGPF)criteria.Postoperative complications were defined according to the Dindo-Clavien classification.All data were statistically analyzed.The optimal thresholds of DFA levels on the first,second and third postoperative days were estimated by constructing receiver operating curves,generated by calculating the sensitivities and specificities of the DFA levels.The DFA level limits were used to differentiate between the group without PF and the groups with biochemical pancreatic fistula(BPF)and CRPF.RESULTS:Pylorus-preserving duodenopancreatectomy was performed on 289(75.6%)patients,while the remaining patients underwent a classic Whipple procedure(CW).The total incidence of PF was 37.7%(grade A22.8%,grade B 11.0%and grade C 3.9%).Soft pancreatic texture(SPT)was present in 58.3%of patients who developed PF.Mortality was 4.2%.The median DFA value on the first postoperative day(DFA1)in patients who developed PF was 4520 U/L(range 350-99000 U/L)for grade A fistula(BPF)with a SPT and a diameter of the main pancreatic duct(MPD)of≤3 mm.For grade B/C(CRPF),the median DFA1 value was 8501 U/L(range377-92060 U/L)with a SPT and MPD of≤3 mm.These values were significantly higher when compared to the patients who did not have PF(122;range 5-37875 U/L).The upper limit of DFA values for the first 3 postoperative days in the examined stages of PF were:DFA1 1200U/L for the BPF and CRPF;DFA3 350 U/L for BPF and DFA3 800 U/L for CRPF.The determined values were highly significant and demonstrated a reliable diagnostic test for both BPF and CRPF.CONCLUSION:DFA1≥1200 U/L is an important predictive factor for PF of any degree.The trend of DFA3(decrease of<50%)compared to DFA1 is a significant factor in the differentiation of CRPF from transient BPF. | Vladimir D Dugalic Djordje M Knezevic Vladan N Obradovic Miroslava G Gojnic-Dugalic Slavko V Matic Aleksandra R Pavlovic-Markovic Predrag D Dugalic Srbislav M Knezevic | 2014 | World Journal of Gastroenterology2014，20，26： | 7 |
| 2 | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study显示文摘AIM To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors.METHODS We used data from PsyC oL aus, a large Swiss Population Cohort Study(n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety(early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders(men), and measles/mumps/rubella-infections with early and late anxiety disorders(women). Gastric inflammatory diseases took effect in mood disorders(both sexes) and in early disorders(men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne(associations with mood disorders in men) and psoriasis(associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders(men), and neurodevelopmental and early anxiety disorders(women).CONCLUSION Infectious, atopic and inflammatory diseases areimportant risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. | Vladeta Ajdacic-Gross Aleksandra Aleksandrowicz Stephanie Rodgers Margot Mutsch Anja Tesic Mario Müller Wolfram Kawohl Wulf R?ssler Erich Seifritz Enrique Castelao Marie-Pierre F Strippoli Caroline Vandeleur Roland von K?nel Rosa Paolicelli Markus A Landolt Cornelia Witthauer Roselind Lieb Martin Preisig | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 3 | Glucagon-like peptide-1 receptor imaging with [Lys 40 (Ahx-HYNIC- 99m Tc/EDDA)NH 2 ]-exendin-4 for the detection of insulinoma显示文摘 | Anna Sowa-Staszczak Dorota Pach Renata Miko?ajczak Helmut M?cke Agata Jabrocka-Hybel Agnieszka Stefańska Monika Tomaszuk Barbara Janota Aleksandra Gilis-Januszewska Maciej Ma?ecki Grzegorz Kamiński Aldona Kowalska Jan Kulig Andrzej Matyja Czes?aw Osuch Al | 2013 | European Journal of Nuclear Medicine and Molecular Imaging2013，，4： | 2 |
| 4 | Effect of eutrophication on changes in the composition of zooplankton in the Grosmca Reservoir (Serbia,Yugoslavia)显示文摘 | ALEKSANDRA M O | 2000 | Hydrobiologia2000，436，： | 1 |
| 5 | AI, Fe - pillared clays in catalytic decolorization of aqueous tartrazine solutions 显示文摘 | Ptedrag B Aleksandra M Zofica M | 2012 | Applied Clay Science2012，58，： | 1 |
| 6 | Distinct cytotoxic mechanisms of pristine versus hydroxylated fullerene 显示文摘 | ALEKSANDRA I ZORAN M BILJANA T M | 2006 | Toxicological Sciences2006，91，1： | 1 |
| 7 | The application of Scanning Electronic Microscopy:The study of the surface of the upper layers of dyed polyester fibre samples in the ostacet yellow E-LSR显示文摘 | MILENA N M MILOVAN M P ALEKSANDRA R Z | 2004 | FACTA Universitis ( Physics Chemistry and Technology )2004，3，1： | 1 |
| 8 | Adsorptive stripping v ohammetric determina- tion of cobalt in the presence of dimethylglyoxime and cetyltrime- thy - lammonium bromide显示文摘 | Mieczyslaw Korolczuk Aleksandra M oroziewicz Malgorzata Grabarczyk | 2004 | Anal biorlal Chem2004，380，： | 1 |
| 9 | Restricted translocation across the cell wall regulates secretion of the broad-range phospholipase C of Listeria monocytogenes显示文摘 | Aleksandra S Helene M | 2003 | J Bacteriol2003，185，： | 1 |
| 10 | Electrochemical Behavior and Antioxidant and Prooxidant Activity of Natural Phenolics显示文摘 | Aleksandra S Dragan M Dejan S | 2007 | Molecules2007，12，： | 1 |
| 11 | Tubules and donuts:a type Ⅵ secretion story显示文摘 | B(o)emann G Aleksandra P Axel M | 2010 | Molecular Microbiology2010，76，4： | 1 |
| 12 | Restricted translocation across the cell wall regulates secretion of the broad -range phospholipase C of Listeria monocytogenes显示文摘 | Aleksandra S Helene M | 2003 | J Bacteriol2003，185，： | 1 |
| 13 | Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice 显示文摘 | Aleksandra M Mariusz T Ernst-Martin | 2007 | PNAS2007，104，： | 1 |
| 14 | pH Optical sensors based on sol-gels: Chemical doping versus covalent immobilization显示文摘 | Aleksandra L Ines O Ivana M | 1998 | Analytica1998，367，13： | 1 |
| 15 | Zinc deficiency in patients with chronic pancreatitis显示文摘BACKGROUND Zinc is a key element in numerous proteins and plays an important role in essential cell functions such as defense against free radicals and DNA damage repair. Chronic pancreatitis(CP) is a chronic inflammation with progressive fibrosis of pancreas ultimately resulting in pancreatic exocrine insufficiency(PEI),which is associated with malnutrition. Studies analyzing zinc levels in patients with CP are sparse and lead to conflicting results.AIM To investigate serum zinc levels in patients with CP of various etiologies.METHODS Between October 2015 and March 2018, patients with a diagnosis of CP were identified and recruited from the Pancreatic Outpatient Clinic at the Karolinska University Hospital in Stockholm, Sweden. Demographic, clinical and laboratory data were analyzed. Etiology of CP was determined according to the MANNHEIM classification system into the following etiological subcategories:alcohol consumption, nicotine consumption, hereditary factors, efferent pancreatic duct factors and immunological factors. Pancreatic exocrine function was defined as normal(fecal elastase 1 > 200 μg/g), mildly reduced(100-200μg/g) and severely reduced(fecal elastase 1 < 100 μg/g).RESULTS A total of 150 patients were included in the analysis. Zinc deficiency(< 11μmol/L) was present in 39(26.0%) of patients: 22 females and 17 males. In the group of patients with zinc deficiency, 76.7% of patients had an exocrine pancreatic insufficiency(FE-1 < 200 μg/g). Older age was significantly associated with low zinc levels. Following a univariate analysis, patients aged 60-69 and patients ≥ 70 years of age had a significantly higher prevalence of zinc deficiencies compared to patients < 40 years of age [OR: 3.8, 95%CI(1.08-13.4); P= 0.04]; [OR 6.26, 95%CI(1.94-20.2), P > 0.002]. Smoking and number of packyears were additionally associated with low zinc levels. The risk of zinc deficiency in current smokers and smokers with ≥ 20 pack-years was approximately three times higher compared to those who had never smoked.Gender, body mass index, etiology of CP, presence of diabetes mellitus, levels of glycated hemoglobin(HbA1 c), bone mineral density, alcohol intake and presence of PEI were not associated with low zinc levels.CONCLUSION Zinc deficiency is common in patients with CP and is significantly associated with age ≥ 60, smoking and the number of pack-years, but not with PEI. | Miroslav Vujasinovic AleksANDra Hedstr?m Patrick Maisonneuve Roberto Valente Henrik von Horn J-Matthias L?hr Stephan L Haas | 2019 | World Journal of Gastroenterology2019，25，5： | 1 |
| 16 | Biodegradation of DNA and nucleotides to nucleosides and free bases显示文摘 | Hanna K Aleksandra M Urszula C | 2004 | Farmaco2004，59，： | 1 |
| 17 | A1,Fe-pillared clays in catalytic decolorization of aqueous tartrazinesolutions 显示文摘 | PREDRAG B ALEKSANDRA M ZORICA M | 2012 | Applied Clay Science2012，58，： | 1 |
| 18 | Relationship between Obesity, Adipocytokines and Inflammatory Markers in Type 2 Diabetes: Relevance for Cardiovascular Risk Prevention显示文摘 | Rajkovic Natasa Zamaklar Miroslava Lalic Katarina Jotic Aleksandra Lukic Ljiljana Milicic Tanja Singh Sandra Stosic Ljubica Lalic Nebojsa M | 2014 | International Journal of Environmental Research and Public Health2014，，4： | 1 |
| 19 | The application of Scanning Electronic Microscopy:The study of the surface of the upper layers of dyed polyester fibre samples in the ostacet yellow E-L5R,FACTA Universities显示文摘 | Milena N M Milovan M P Aleksandra R Z | 2004 | Physics Chemistry and Technology2004，3，1： | 1 |
| 20 | Inducible nitric -oxide synthase is regulated by the proteasome degradation pathway 显示文摘 | Aleksandra M Tony E | 2001 | J Biol Chem2001，276，24： | 1 |
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