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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | 更年期医学:欧洲男女更年期协会2004/2005关于围绝经期和绝经后激素补充治疗的立场声明显示文摘目前从大量的随机对照临床试验(RCT)中已得出结论性的证据:对于经历令人痛苦的更年期症状的围绝经期和绝经后妇女,任何形式的全身HRT均可以缓解症状,没有其它治疗手段能产生相似效果。尽管这种证据与日俱增,但如何提供最好的临床医疗以减轻绝经症状和预防较远期的绝经后退化性疾病,仍在争论之中。当提供更年期医药时,HRT的剂量和方案的个体化是基于与症状的严重程度和绝经时间相关的最低有效剂量的原则。然而,在有症状的妇女中,尚没有多少关于长期应用不同HRT方案的资料,同时赖以说明心血管疾病、乳腺癌和骨质疏松症的基线风险的影响。在大多数病例中,个体化的处方联同生活方式的调整就可能对更年期症状、生活质量、性问题和骨质疏松症产生最终有益的作用,罕见严重副反应。基于最近的流行病学研究,不少是来自WHI中单用雌激素组的结果,欧洲男女更年期协会(EMAS)支持在有症状的妇女中进行新的HRT方案的研究,以提高临床中受益和风险之间的平衡,包括生活质量方面特有的信息;并解释美国和欧洲之间在治疗模式上的传统差异,以及在BMI、生活方式和饮食习惯方面的不同所产生的影响。对于早绝经(<45岁)的妇女,现有的资料支持HRT所特有的总体益处。目前,具有骨质疏松性骨折高危险性的妇女可考虑应用较长期的全身HRT,尤其是当其它治疗措施既不恰当又疗效不佳时,因为此时收益大于风险。而对于泌尿生殖道症状,已认为长期的局部雌激素治疗可能安全和有效。 | Sven O.Skouby Farook Al-Azzawi David Barlow Joaquin Calaf-Alsina Erdogan Ert ungealp Anne Gompel Alessandra Graziottin Decebal Hudita Amos ines Serge Rozenberg Gran Samsioe John C.Stevenson 陈瑛 | 2005 | 国外医学(妇幼保健分册)2005，16，5： | 3 |
| 3 | The jasmonate signal pathway显示文摘 | John Turner G Christine E Alessandra D | 2002 | Plant Cell2002，14，： | 1 |
| 4 | Repartition effect of aromatic polyaniline coatings on the separation of bioactive peptides in capillary electrophoresis显示文摘 | ALESSANDRA B SERGEY A P ANTHONY P F T PIER G R | 2002 | Electrophoresis2002，23，2： | 1 |
| 5 | Detection of genetically modified soybean using peptide nucleic acids (PNAs)and microarray technology显示文摘 | Andrea G Alessandra M Francesca L | 2005 | Journal of Agricultural and Food Chemistry2005，52，14： | 1 |
| 6 | Lipolysis and lipid oxidation in fermented sausages depending on different processing conditions and different antioxidants显示文摘 | Emanuela Z Sergio G Alessandra B | 2004 | Meat Science2004，66，： | 1 |
| 7 | US-- elastography in the differential diagnosis of benign and ma- lignant thyroid nodules显示文摘 | CARMELA A ALESSANDRA G ALESSANDRO P | 2008 | Thyroid2008，18，3： | 1 |
| 8 | Hepcidin in obese children as a potential mediator of the asso- ciation between obesity and iron deficiency 显示文摘 | MIRAGLIA-DEL G E NICOLA S ALESSANDRA A | 2009 | J Clin Endo- crinol Metab2009，94，12： | 1 |
| 9 | Lipolysis and lipid oxidation in fermented sausages depending on different processing conditions and different antioxidants 显示文摘 | Emanuela Z Sergio G Alessandra B | 2004 | Meat Science2004，66，： | 1 |
| 10 | Lipolysis and lipid oxidation in fermented sausages depending on different processing conditions and different antioxidants显示文摘 | EMANUELA Z SERGIO G ALESSANDRA B | 2004 | Meat Science2004，66，2： | 1 |
| 11 | Application of the SPI(Saliva Precipitation Index)to the evaluation of red wine astringency显示文摘 | ALESSANDRA R ANGELITA G LUIGI M | 2012 | Food Chemistry2012，135，4： | 1 |
| 12 | Chip electrophoresis as a novel approach to measure the polyphenols reactivity toward human saliva显示文摘 | ALESSANDRA R NEREA I ANGELITA G | 2014 | Electrophoresis2014，35，11： | 1 |
| 13 | US- elastography in the differential diagnosis of benign and malignant thyroid nodules显示文摘 | Carmela A Alessandra G Alessandro P | 2008 | Thyroid2008，18，5： | 1 |
| 14 | Management of pulmonary arterial hypertension associatedwith congenital systemic to pulmonary shunts and eisenmengerps syndrome显示文摘 | NAZZARENO G ALESSANDRA M MASSIMILIANO P | 2008 | Drugs2008，68，8： | 1 |
| 15 | NMR, XRD, IR and synchrotron NEXAFS spectroscopic studies of OPC and OPC slag cement paste hydrates 显示文摘 | Alessandra M win P G Jay G | 2011 | Materials and Structures2011，44，： | 1 |
| 16 | Contact profilometry and correspondence analysis to correlate surface properties and cell adhesion in vitro of uncoated and coated Ti and Ti6Al4V disks 显示文摘 | Andrea B Marco G Alessandra L | 2004 | Biomaterials2004，25，12： | 1 |
| 17 | Molecular Epidemiology of Escherichia coli Producing Extended - spectrum β- Laetamases Isolated in Rome ,Italy显示文摘 | Alessandra C Aurora G F Paola V | 2008 | J Clin Mierob2008，46，1： | 1 |
| 18 | Recombinant human erythropoietin improves angiogenesis and wound healing in experimental burn wounds 显示文摘 | Mariarosaria G Domenica A Alessandra B | 2006 | J Crit Care2006，4，34： | 1 |
| 19 | Neuroprotection by erythropoietin administration after experimental traumatic brain injury 显示文摘 | Giovanni G Alessandra S Francesco M | 2007 | Brain Res2007，1182，： | 1 |
| 20 | Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide stimulated human monocytes 1 显示文摘 | Vanesa G Alessandra SS Alexandro RR | 2007 | J Immunol2007，179，9： | 1 |
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