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| 1 | Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?显示文摘Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC. | Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo Leonardo Solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini | 2018 | World Journal of Gastroenterology2018，24，36： | 14 |
| 2 | A systematic review and meta-analysis of clinical trials implementing aromatase inhibitors to treat male infertility显示文摘Aromatase activity has commonly been associated with male infertility characterized by testicular dysfunction with low serum testosterone and/or testosterone to estradiol ratio.In this subset of patients,and particularly in those with hypogonadism,elevated levels of circulating estradiol may establish a negative feedback on the hypothalamic–pituitary–testicular axis by suppressing follicle-stimulating hormone(FSH)and luteinizing hormone(LH)production and impaired spermatogenesis.Hormonal manipulation via different agents such as selective estrogen modulators or aromatase inhibitors to increase endogenous testosterone production and improve spermatogenesis in the setting of infertility is an off-label option for treatment.We carried out a systematic review and meta-analysis of the literature of the past 30 years in order to evaluate the benefits of the use of aromatase inhibitors in the medical management of infertile/hypoandrogenic males.Overall,eight original articles were included and critically evaluated.Either steroidal(Testolactone)or nonsteroidal(Anastrozole and Letrozole)aromatase inhibitors were found to statistically improve all the evaluated hormonal and seminal outcomes with a safe tolerability profile.While the evidence is promising,future prospective randomized placebo-controlled multicenter trials are necessary to better define the efficacy of these medications. | Francesco Del Giudice Gian Maria Busetto Ettore De Berardinis Isabella Sperduti Matteo Ferro Martina Maggi Martin S Gross Alessandro Sciarra Michael L Eisenberg | 2020 | Asian Journal of Andrology2020，22，4： | 5 |
| 3 | Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreatitis显示文摘Acute pancreatitis is an inflammation of the pancreas that may lead to systemic inflammatory response syndrome and death due to multiple organ failure. Acinar cells, together with leukocytes, trigger the inflammatory cascade in response to local damage of the pancreas. Amplification of the inflammatory cascade requires up-regulation of proinflammatory cytokines and this process is mediated not only by nuclear factor κB but also by chromatinmodifying complexes and chromatin remodeling. Among the different families of histone acetyltransferases, the p300/CBP family seems to be particularly associated with the inflammatory process. cAMP activates gene expression via the cAMP-responsive element (CRE) and the transcription factor CRE-binding protein (CREB). CREB can be phosphorylated and activated by different kinases, such as protein kinase A and MAPK, and then it recruits the histone acetyltransferase co-activator CREB-binding protein (CBP) and its homologue p300. The recruitment of CBP/p300 and changes in the level of histone acetylation are required for transcription activation. Transcriptional repression is also a dynamic and essential mechanism of down-regulation of genes for resolution of inflammation, which seems to be mediated mainly by protein phosphatases (PP1, PP2A and MKP1) and histone deacetylases(HDACs) .Class HDACs are key transcriptional regulators whose activities are controlled via phosphorylationdependent nucleo/cytoplasmic shuttling. PP2A is responsible for dephosphorylation of class HDACs, triggeringnuclear localization and repression of target genes, whereas phosphorylation triggers cytoplasmic localization leading to activation of target genes. The potential benefit from treatment with phosphodiesterase inhibitors and histone deacetylase inhibitors is discussed. | Javier Escobar Javier Pereda Alessandro Arduini Juan Sastre Juan Sandoval Luis Aparisi Gerardo López-Rodas Luis Sabater | 2010 | World Journal of Gastrointestinal Pharmacology and Therapeutics2010，1，3： | 2 |
| 4 | Triiodothyronine levels for risk stratification of patients with chronic heart failure显示文摘 | Alessandro Pingitore Patrizia Landi Maria Chiara Taddei Andrea Ripoli Antonio L’Abbate Giorgio Iervasi | 2005 | The American Journal of Medicine2005，，2： | 2 |
| 5 | Modelling and control of nonholonomic mechanical systems 显示文摘 | ALESSANDRO D L GIUSEPPE O | 1995 | Kinematics and Dynamics of Multi-Body Systems1995，66，18： | 1 |
| 6 | Improvement of Biohydrogen Production from Solid Wastes by Intermittent Venting and Gas Flushing of Batch Reactors Headspace显示文摘 | Idania V V Elvira R L Alessandro C M | 2006 | Environ Sci Technol2006，40，10： | 1 |
| 7 | Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66shc Gene显示文摘 | Marcello Rota Nicole LeCapitaine Toru Hosoda Alessandro Boni Antonella De Angelis Maria Elena Padin-Iruegas Grazia Esposito Serena Vitale Konrad Urbanek Claudia Casarsa Marco Giorgio Thomas F. Lüscher Pier Giuseppe Pelicci Piero Anversa Annarosa Leri Jan | 2006 | Circulation Research2006，，1： | 1 |
| 8 | Recognition and verification of unconstrained handwritten words 显示文摘 | ALESSANDRO L Koerich | 2005 | IEEE TPAMI2005，27，10： | 1 |
| 9 | Prognostic value of combined measurment of brain natriuretic pep- tide and tri - iodothyronine in heart failure 显示文摘 | Claudio P Alessandro P Patrizia L | 2009 | J Cardic Failure2009，15，： | 1 |
| 10 | Dual mechanism for the control of inducible-type NO synthase ene expression in macrophages during activation by interferon-γ and lipopolysaccharide显示文摘 | Alessandro W Shinobu L Luigi C | 1994 | J Biol Chem1994，269，11： | 1 |
| 11 | Correlation between ultimate tensile strength and solidification microstmcture for the sand cast A357 aluminium alloy显示文摘 | Ceschini L Alessandro Morri Andrea Morri | 2009 | Materials and Design2009，30，10： | 1 |
| 12 | Incidence and short-term prognosis of status epilepticus in adults in Bologna,Italy显示文摘 | Vignatelli L Tonon CD Alessandro R | | 0，，： | 1 |
| 13 | Evaluation of a new rapid quantitative D-dimer assay in patients with clinically suspected deep vein thrombosis显示文摘 | D'Angelo A D'Alessandro G Tomassini L | | 0，，3： | 1 |
| 14 | Use of Sorafenib in Patients With Hepatocellular Carcinoma Before Liver Transplantation:A Cost-Benet Analysis While Awaiting Data on Sorafenib Safety显示文摘 | Alessandro Vitale Michael L Volk | 2010 | HEPATOLOGY2010，51，1： | 1 |
| 15 | Productivity, innovation and R&D:Micro evidence for Italy显示文摘 | MARIA L P FABIO S ALESSANDRO S | 2006 | Europe- an Economic Review2006，，50： | 1 |
| 16 | How the FSH/ LH ratio and dose numbers in the p-FSH administration treat- ment regime,and insemination schedule affect superovulatory re- sponse in ewes显示文摘 | Alessandro A G D Marternucci G Taibi L | 2004 | Theriogenology2004，286，45： | 1 |
| 17 | A Field Study of Reflectivity and Z-R Relations Using Vertically Pointing Radars and Disdrometers显示文摘 | Tokay Ali Hartmann Peter Battaglia Alessandro Gage Kenneth S Clark Wallace L Williams Christopher R | 2009 | Journal of Atmospheric and Oceanic Technology2009，，6： | 1 |
| 18 | Monitoring landslides from optical remotely sensed imagery: the case history of Tessina landslide, Italy显示文摘 | Javier Hervás José I Barredo Paul L Rosin Alessandro Pasuto Franco Mantovani Sandro Silvano | 2003 | Geomorphology2003，，1： | 1 |
| 19 | Reduced Peripheral Skeletal Muscle Mass and Abnormal Reflex Physiology in Chronic Heart Failure显示文摘 | Massimo F. Piepoli Agnieszka Kaczmarek Darrel P. Francis L Ceri Davies Mathias Rauchhaus Ewa A. Jankowska Stefan D. Anker Alessandro Capucci Waldemar Banasiak Piotr Ponikowski | 2006 | Circulation2006，，： | 1 |
| 20 | Comparison of parecoxib and proparacetamoI in endoscopic nasal surgery palients 显示文摘 | YIGAL L ANDREA C ALESSANDRO R | 2008 | Yonsei Med J2008，49，3： | 1 |
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