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| 1 | A Peroxidase Contributes to ROS Production during Arabidopsis Root Response to Potassium Deficiency显示文摘反应的氧种类(ROS ) 玩在对由调整高亲密关系的 K+ transporter 基因 AtHAK5 和另外的基因的表示的钾剥夺的根回答的一个重要角色。包含驾驶酶的 AtHAK5 倡导者的 Arabidopsis 植物的标注激活的线在钾足够的条件下面为生物体之发光被屏蔽。类型 III peroxidase 家庭,的一个成员 RCI3,被孤立,当它是由激活标签的 overexpressed 时,这导致了酶和内长的 AtHAK5 的提高的表示。RCI3 被发现在钾剥夺之上起来调整。而 ROS 生产和 AtHAK5 表示在剥夺 K+ 的条件下面在 rci3-1 被减少,植物 overexpressing RCI3 (RCI3 公牛) 显示出更多的 ROS 生产和 AtHAK5 表示。这些结果建议 RCI3 在钾剥夺下面涉及 ROS 的生产,那调停 RCI3 的 ROS 生产影响 AtHAK5 表示的规定。这 peroxidase 看起来是在 Arabidopsis 根的低钾的信号 transduction 小径的另一个部件。 | Min Jung Kim Silvano Ciani Daniel P. Schachtman | 2010 | Molecular Plant2010，3，2： | 29 |
| 2 | Molecular and phenotypic characterization of human amniotic fluid cells and their differentiation potential显示文摘学习的主要目标是多识别人的新奇来源有势力房间,克服涉及胚胎的干细胞研究和很成年的干细胞的有限可获得性的道德的问题。羊膜的液体房间(声频抗流圈) 习惯性地为出生前的诊断被获得并且能在 vitro 被扩展;他们的起源和性质的不过当前的知识是有限的。声频抗流圈的二十件样品在文化暴露于 adipogenic, osteogenic,神经原并且 myogenic 媒介。区别用免疫细胞化学, RT-PCR 并且西方的弄污被评估。在处理前,声频抗流圈显示出异构的形态学。他们为 MyoD, Myf-5, MRF4, Myogenin 和 Desmin 是否定的但是为由 RT-PCR 的 osteocalcin, PPARgamma2, GAP43, NSE, Nestin, MAP2, GFAP 和贝它导管素 III 积极。房间表示了 Oct-4, Rex-1 和 Runx-1,它描绘无差别的干细胞状态。由免疫细胞化学,他们表示了 neural-glial 蛋白质,间充质、上皮的标记。在文化以后,当占优势的细胞的部件是 fibroblastic 时,声频抗流圈区分了进 adipocytes 和造骨细胞。就算没有 neuronal 形态学是可检测的,早、迟了的 neuronal 抗原仍然是在在神经特定的媒介的 2 星期文化以后的现在。我们的结果提供人的羊膜的液体与为几个系显示出茎和织物特定的基因 / 蛋白质存在的多系潜力包含祖先房间的证据。 | Patrizia Bossolasco Tiziana Montemurro Lidia Cova Stefano Zangrossi Cinzia Calzarossa Simona Buiatiotis Davide Soligo Silvano Bosari Vincenzo Silani Giorgio Lambertenghi Deliliers PaoloRebulla LorenzaLazzari | 2006 | Cell Research2006，16，4： | 20 |
| 3 | Chemokine and chemotactic signals in dendritic cell migration显示文摘Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation of specific T-cell responses and for thedevelopment of immune tolerance. Immature DCs reside in peripheral tissues and specialize in antigen capture, whereas matureDCs reside mostly in the secondary lymphoid organs where they act as antigen-presenting cells. The correct localization of DCs isstrictly regulated by a large variety of chemotactic and nonchemotactic signals that include bacterial products, DAMPs (dangerassociated molecular patterns), complement proteins, lipids, and chemokines. These signals function both individually and inconcert, generating a complex regulatory network. This network is regulated at multiple levels through different strategies, such assynergistic interactions, proteolytic processing, and the actions of atypical chemokine receptors. Understanding this complexscenario will help to clarify the role of DCs in different pathological conditions, such as autoimmune diseases and cancers and willuncover new molecular targets for therapeutic interventions. | Laura Tiberio Annalisa Del Prete Tiziana Schioppa Francesca Sozio Daniela Bosisio Silvano Sozzani | 2018 | Cellular & Molecular Immunology2018，15，4： | 14 |
| 4 | Treatment of central precocious puberty by GnRH analogs: long-term outcome in men显示文摘在男孩,中央早熟的发身(CPP ) 是以前垂体促性腺激素分泌物驾驶的第二等的性别特征的外观 9 年的年龄。在最后年里,在 CPP 的处理的相关改进被完成了。因为 CPP 在男孩是稀罕的,这个问题上的报纸的多数集中于女孩并且不关于结束结果和安全探讨男病人的特定的特征。在现在的纸,有在男人的 GnRH 类似物的 CPP 管理的最近的进展被总结。在未经治疗、对待的病人的结束结果被最近出版的文学的分析也在男人在 CPP 的治疗上考察。可得到的数据显示没有重要不利短期、长期的效果,有 GnRH 类似物的那治疗能改进最后的高度进目标高度的范围,但是病人的更大的系列的更长的后续是仍然要求了得出权威的结论。 | Silvano Bertelloni Dick Mul | 2008 | Asian Journal of Andrology2008，10，4： | 13 |
| 5 | 用于光电仪器和相关测量的自混合干涉技术(特邀)显示文摘回顾了一种全新结构的干涉仪—自混合干涉仪(SMI)的发展情况。SMI由于其在激光器外部无需任何光学元件且应用范围广泛而倍受关注。SMI可用于测量与光路长度有关的一些量(如位移、小幅度振动、速度),也可用于测量弱光的回波(即回波损耗和隔离因子的测量)并可表征与介质相互作用特性相关的物理参数(如激光线宽、相干长度以及α因子等)。SMI是一种相干探测方法,其工作在靠近接收场的量子极限处,目前对散射目标物的最小探测幅值可达槡20 pm/(Hz)~(1/2)甚至更高,使用角锥棱镜使其计数步长为半波长,在动态范围为2 m时其分辨率约为0.5μm。另外,SMI结构紧凑、易于现场安装且可用于MEMS测试、旋转机械振动测试和生物运行测试等各种实验。 | DONATI Silvano 王昭 禹延光 | 2012 | 中国光学2012，5，2： | 8 |
| 6 | 深挖核心工艺,紧追技术进步(一)——再论葡萄酒酒精发酵质量的保障策略显示文摘酒精发酵是葡萄酒酿造的最核心工艺之一,通过各种酿酒酵母的作用,糖转化为乙醇,葡萄汁转化为酒液,同时释放出大量有益物质和香气组分,形成各具特色的不同酒基,这是葡萄酒酿造最关键的第一步。 | 郭永亮 俞惠明 刘宗芳 王晓峰 王平来 Anthony SILVANO | 2011 | 中外葡萄与葡萄酒2011，，2： | 6 |
| 7 | Osteoporosis Treatment:When to Discontinue and When to Re-start显示文摘A number of effective therapies for the treatment of osteoporosis have become available in recent years.However,uncertainty exists regarding their long-term use and effectiveness.Bisphosphonate treatment,unlike hormone replacement,denosumab or teriparatide,is associated with benefits extended even after treatment discontinuation.The extended benefits are most apparent for alendronate(ALN)and zoledronate(ZOL).A drug holiday might be considered in patients at low-moderate risk and who have been fully compliant with treatment,and who have had a response to treatment.In patients at low-moderate risk of fractures the decision to consider a drug holiday should be balanced also with the safety profile of each treatment. | Silvano Adami Luca Idolazzi Elena Fracassi Davide Gatti Maurizio Rossini | 2013 | Bone Research2013，1，4： | 6 |
| 8 | 现代葡萄酒陈酿工艺探讨显示文摘带酒泥陈酿(Surlie)是指发酵后的葡萄酒在木桶或罐中贮藏时带部分好的酒泥进行陈酿。它最早只是用于勃艮第地区葡萄酒和香槟地区起泡酒的酿造,以提高酒体饱满度和耐储性为其工艺目标。随着研究的深入,带酒泥陈酿的积极作用也Et益明确,并逐渐被广泛用于各类高品质酒品的酿造实践。 | 郭永亮 Anthony SILVANO | 2012 | 中外葡萄与葡萄酒2012，，6： | 6 |
| 9 | HER2 aberrations and heterogeneity in cancers of the digestive system: Implications for pathologists and gastroenterologists显示文摘Management of cancers of the digestive system has progressed rapidly into the molecular era. Despite the significant recent achievements in the diagnosis and treatment of these patients, the number of deaths for these tumors has currently plateaued. Many investigations have assessed the role of HER2 in tumors of the digestive system in both prognostic and therapeutic settings, with heterogeneous results. Novel testing and treatment guidelines are emerging, in particular in gastric and colorectal cancers. However, further advances are needed. In this review we provide a comprehensive overview of the current state-ofknowledge of HER2 alterations in the most common tumors of the digestive system and discuss the operational implications of HER2 testing. | Nicola Fusco Silvano Bosari | 2016 | World Journal of Gastroenterology2016，22，35： | 5 |
| 10 | Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes显示文摘 | Alberto Mantovani Silvano Sozzani Massimo Locati Paola Allavena Antonio Sica | 2002 | Trends in Immunology2002，，11： | 4 |
| 11 | Outcome of non-variceal acute upper gastrointestinal bleeding in relation to the time of endoscopy and the experience of the endoscopist: A two-year survey显示文摘AIM: To prospectively assess the impact of time of endoscopy and endoscopist's experience on the outcome of non-variceal acute upper gastrointestinal (GI) bleeding patients in a large teaching hospital.METHODS: All patients admitted for non-variceal acute upper GI bleeding for over a 2-year period were potentially eligible for this study. They were managed by a team of seven endoscopists on 24-h call whose experience was categorized into two levels (high and low) according to the number of endoscopic hemostatic procedures undertaken before the study. Endoscopic treatment was standardized according to Forrest classification of lesions as well as the subsequent medical therapy. Time of endoscopy was subdivided into two time periods: routine (8 a.m.-5 p.m.) and on-call (5 p.m.-8 a.m.). For each category of experience and time periods rebleeding rate, transfusion requirement, need for surgery, length of hospital stay and mortality we compared. Multivariate analysis was used to discriminate the impact of different variables on the outcomes that were considered.RESULTS: Study population consisted of 272 patients (mean age 67.3 years) with endoscopic stigmata of hemorrhage. The patients were equally distributed among the endoscopists, whereas only 19% of procedures were done out of working hours. Rockall score and Forrest classification at admission did not differ between time periods and degree of experience.Univariate analysis showed that higher endoscopist's experience was associated with significant reduction in rebleeding rate (14% vs 37%), transfusion requirements (1.8±0.6 vs 3.0±1.7 units) as well as surgery (4% vs 10%), but not associated with the length of hospital stay nor mortality. By contrast, outcomes did not significantly differ between the two time periods of endoscopy.On multivariate analysis, endoscopist's experience was independently associated with rebleeding rate and transfusion requirements. Odds ratios for low experienced endoscopist were 4.47 for rebleeding and 6.90 for need of transfusion after the endoscopy.CONCLUSION: Endoscopist's experience is an important independent prognostic factor for non-variceal acute upper GI bleeding. Urgent endoscopy should be undertaken preferentially by a skilled endoscopist as less expert staff tends to underestimate some risk lesions with a negative influence on hemostasis. | Fabrizio Parente Andrea Anderloni Stefano Bargiggia Venerina Imbesi Emilio Trabucchi Cinzia Baratti Silvano Gallus Gabriele Bianchi Porro | 2005 | World Journal of Gastroenterology2005，11，45： | 4 |
| 12 | Coffee Reduces Risk for Hepatocellular Carcinoma: An Updated Meta-Analysis显示文摘 | Francesca Bravi Cristina Bosetti Alessandra Tavani Silvano Gallus Carlo La Vecchia | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 3 |
| 13 | 深挖核心工艺,紧追技术进步(二)——葡萄酒专业酵母的筛选开发与实践应用显示文摘作为葡萄酒酿造的灵魂,专业酵母的筛选开发和实践应用一直是葡萄酿酒学中最为核心的技术问题。世界顶级的酿酒学家从自然界筛选并开发专业菌种,酒师应该如何根据自己的酿造目标和原料状况选择并应用好这些专业酵母,生产出独特的佳酿? | 都振江 郭永亮 Anthony SILVANO | 2011 | 中外葡萄与葡萄酒2011，，3： | 3 |
| 14 | Helicobacter pylori-negative Russell body gastritis:Case report显示文摘Russell body gastritis is an unusual form of chronic gastritis characterized by the permeation of lamina propria by numerous plasma cells with eosinophilic cytoplasmic inclusions.Very few cases have been reported in the literature;the majority of which have shown Helicobacter Pylori(H.pylori)infection,thus suggesting a correlation between plasma cell presence and antigenic stimulation by H.pylori.We present a case of Russell body gastritis in a 78-year-old woman who was undergoing esophagogastroduodenoscopy for epigastric pain.Gastric biopsy of the gastroesophageal junction showed the presence of cells with periodic acid-Schiff-positive hyaline pink bodies.Giemsa staining for H.pylori infection was nega-tive,as well as immunohistochemical detection.The cells with eosinophilic inclusions stained positive for CD138,CD79a,andκand lambda light chains,which confirmed plasma cell origin.In particular,κand lambda light chains showed a polyclonal origin and the patient was negative for immunological dyscrasia.The histological observations were confirmed by ultrastructural examination.The cases reported in the literature associated with H.pylori infection have shown regression of plasma cells after eradication of H.pylori.Nothing is known about the progression of H.pylori-negative cases.The unusual morphological appearance of this type of chronic gastritis should not be misinterpreted during routine examination,and it should be distinguished from other common forms of chronic gastritis.It is mandatory to exclude neoplastic diseases such as gastric carcinoma, lymphoma and plasmocytoma by immunohistochemistry and electron microscopy,which can help with differential diagnosis.The long-term effects of plasma cells hyperactivation are still unknown,because cases of gastric tumor that originated in patients affected by Russell body gastritis have not been described in the literature.We are of the opinion that these patients should be scheduled for endoscopic surveillance. | Alessandro Del Gobbo Luca Elli Paola Braidotti Franca Di Nuovo Silvano Bosari Solange Romagnoli | 2011 | World Journal of Gastroenterology2011，17，9： | 3 |
| 15 | Major early complications from diagnostic and therapeutic ERCP: a prospective multicenter study显示文摘 | Silvano Loperfido Giampaolo Angelini Giorgio Benedetti Fausto Chilovi Franco Costan Franco De Berardinis Massimo De Bernardin Andrea Ederle Paolo Fina Agostino Fratton | 1998 | Gastrointestinal Endoscopy1998，，1： | 2 |
| 16 | Quantification of dependencies between electrical and information infrastructures显示文摘 | Marco Beccuti Silvano Chiaradonna Felicita Di Giandomenico Susanna Donatelli Giovanna Dondossola Giuliana Franceschinis | 2012 | International Journal of Critical Infrastructure Protection2012，，1： | 2 |
| 17 | Removal of Lead,Copper,Zinc and Cadmium from Water Using Phosphate Rock显示文摘摘要:Pb2+ 的移动, Cu2+ ,由自然磷酸盐岩石(FAP ) 上的吸着的 Zn2+and Cd2+from 水的答案被调查。接触时间和起始的金属集中的效果在批方法被检验。从答案的重金属的百分比吸着在 50% 和 99% 之间通常变化。sorbed 金属离子的数量跟随顺序 Cu > Pb > Cd > Zn。重金属固定在重包含金属的磷酸盐的 FAP 谷物和部分溶解和猛冲的表面上被归因于金属离子的两表面 complexation。重金属的低解吸附作用比率进一步作为其他、便宜的材料支持 FAP 的有效性移开有毒的 Pb2+ , Cu2+ , Zn2+and Cd2+from 弄脏水。 | Alessia CORAMI Silvano MIGNARDI Vincenzo FERRINI | 2008 | Acta Geologica Sinica(English Edition)2008，82，6： | 2 |
| 18 | Advanced oxidation and adsorption technologies for organic micropollutant removal from lake water used as drinkingwater supply 显示文摘 | Guzzella Licia Feretti Donatella Monarca Silvano | 2002 | Water Res2002，36，17： | 1 |
| 19 | Identification of free and bound volatile compounds as typicalness and authenticity markers of non-aromatic grapes and wines through a combined use of mass spectrometric techniques 显示文摘 | Antonella N Pasquale F Silvano A | 2008 | Food Chemistry2008，，110： | 1 |
| 20 | Selective determination of aromatic amines in water samples by capillary zone electrophoresis and solid-phase extraction显示文摘 | ALDO C VITTORIO P FLAVIA N SILVANO C CLAUDIO R | 1995 | J Chromatogr:A1995，709，2： | 1 |
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