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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | The effect of adjunct caudal block on postoperative analgesia in robot-assisted laparoscopic radical prostatectomy: A prospective randomized controlled, single blinded pilot study in a tertiary centre显示文摘Objective:Caudal block provides satisfactory postoperative pain relief in lower abdominal operations.This pilot study explores its safety and effect on postoperative pain control in patients who underwent robot-assisted laparoscopic radical prostatectomy(RARP).Methods:From 2013 to 2014,40 consecutive patients were randomized into two groups d one received caudal block using ropivacaine immediately after operation,the other received standard analgesia.Primary outcome measure was pain score based on 11-point Likert scale(0e10)recorded at recovery room,and at 6,12,24,48,and 72 h after operation.All analgesic requirements,opioid-related adverse events and time to passage of flatus were examined.Results:Mean age of the two groups was similar(60.4 vs.62.3 years,p Z 0.33),as was American Society of Anaesthesiologists(ASA)class,body mass index(BMI)and operation times.No significant difference in median pain scores was reported in recovery room(2 vs.3,p Z 0.34),and at 6 h(2 vs.2,p Z 0.94),12 h(0 vs.0,p Z 0.62),24 h(1 vs.0,p Z 0.58),48 h(1 vs.0,p Z 0.36)and 72 h(0 vs.0,p Z 0.78)postoperatively between control and caudal block groups,respectively.There was a higher mean opioid usage in the caudal block group which was not statistically significant.Although this was statistically insignificant while no significant difference in mean paracetamol usage was observed postoperatively.Median time to passage of flatus was similar(2.0 vs.2.0 days,p Z 0.97).There was one case of superficial wound infection and no opioid-related adverse events observed.Hospital stay was similar in both groups(2.5 vs.2.5 days,p Z 0.96). | Kenneth Chen Allen Sim Alex Ford Kan | 2018 | Asian Journal of Urology2018，5，2： | 3 |
| 3 | 成人类风湿关节炎的诊断和管理:NICE指南更新概要显示文摘类风湿关节炎是一种慢性、致残的自身免疫病,主要以大小关节的滑膜炎引起肿胀、晨僵、疼痛和进行性关节破坏为特征。英国人的患病率约1%,其中约15%为重度类风湿关节炎。女性患病率约为男性的3倍。可见于任何年龄,但40~60岁好发。类风湿关节炎的早期表现为关节疼痛和肿胀。快速、准确地转诊至风湿科对实现早期缓解、预防或减少残疾至关重要。 | Alex Allen Serena Carville Frank McKenna 白明欣(译) 姚海红(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 3 |
| 4 | Groundwater-surface water interaction under scenarios of climate change using a high-resolution transient groundwater model显示文摘 | Jacek Scibek Diana M Allen Alex J Cannon Paul H Whitfield | 2006 | Journal of Hydrology2006，，8： | 1 |
| 5 | Cumulative viral evolutionary changes in chronic hepatitis B virus infection precedes hepatitis B e antigen seroconversion显示文摘 | Yan Cheng Stephane Guindon Allen Rodrigo Lin Ying Wee Masafumi Inoue Alex J V Thompson Stephen Locarnini Seng Gee Lim | 2013 | Gut2013，，9： | 1 |
| 6 | Focal therapy for localised unifocal and multifocal prostate cancer: a prospective development study显示文摘 | Hashim U Ahmed Richard G Hindley Louise Dickinson Alex Freeman Alex P Kirkham Mahua Sahu Rebecca Scott Clare Allen Jan Van der Meulen Mark Emberton | 2012 | Lancet Oncology2012，，： | 1 |
| 7 | Using Community-Based Participatory Research (CBPR) to Develop a Community-Level HIV Prevention Intervention for Latinas: A Local Response to a Global Challenge显示文摘 | Scott D. Rhodes Casey Kelley Florence Simán Rebecca Cashman Jorge Alonzo Jamie McGuire Teresa Wellendorf Kathy Hinshaw Alex Boeving Allen Mario Downs Monica Brown Omar Martínez Stacy Duck Beth Reboussin | 2012 | Women’s Health Issues2012，，3： | 1 |
| 8 | 分级脂肪抽吸物:是否存在用于脂肪移植的最佳密度显示文摘背景与目的脂肪移植的临床效果是不可预知的。本文中,我们假设离心可以产生“梯度等级密度”的具有不同特性的脂肪,可以影响脂肪抽吸物的持久性和质量。方法将人类女性脂肪抽吸物样本(10mI)以1200g速率离心3rain。弃血液和油脂成分。随后,分离出1.0ml密度最高与密度最低的脂肪,进行脂肪浸润处理及分析。将密度最高与密度最低的脂肪移植于人体FVB小鼠,然后分别于2周和10周获取组织样本,进行短期与长期持久性评价。分别通过流式细胞术和酶联免疫吸附实验,分析祖细胞数量以及血管内皮细胞生长因子(vascularendothelialgrowthfactor,VEGF)、基质细胞来源因子.1(stromalcell—derivedfactor-1,SDF-1)、血小板来源生长因子(platelet—derivedgrowthfactor,PDGF)和脂连蛋白的表达。结果高密度脂肪与低密度脂肪相比,注射后2周[(85.4%±1.9%):(62.3±0.1%),P=0.05]和10周[(60.8%±4.9%):(42.2%±3.9%),P〈0.05]均表现出更高的存活百分率。而且,在高密度的脂肪抽吸物细胞群中,VEGF、基质血管成分(stromalvascularfraction,SVF)、PDGF和脂连蛋白的含量均比低密度的高(分别高出34.4%,P〈0.01;34.6,P〈0.05;52.2%,P〈0.01;45.7%,P〈0.05)。结论与低密度脂肪细胞群相比,随时间增长,高密度脂肪抽吸物细胞群可保持更高的存活百分比。因为高密度脂肪抽吸物细胞群包含更多的祖细胞和更大浓度的多种血管形成介质,所以比低密度脂肪细胞群更有助于血管形成。 | Robert J. Allen Orlando Canizares Carrie Scharf Phuong D. Nguyen Vishal Thanik Pierre B.Saadeh Sydney R. Coleman Alexes Hazen 魏峰 高景恒 张晨 | 2014 | 中国美容整形外科杂志2014，25，4： | 0 |
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