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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development显示文摘 | Hansen L A Alexander N Hogan M E Sundberg J P Dlugosz A Threadgill D W Magnuson T Yuspa S H | | 0，，06： | 1 |
| 3 | Plant-microorganism-soil interactions influence the Fe availability in the rhizosphere of cucumber plants 显示文摘 | Youry P Alexander P Roberto T | 2015 | Plant Physiology and Biochemistry2015，87，： | 1 |
| 4 | Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways显示文摘 | Larsen C P Elwood E T Alexander D Z | 1996 | Nature1996，381，6581： | 1 |
| 5 | A comprehensive map of the porcine genome 显示文摘 | Rohrer G A Alexander L J Hu Z Smith T P L Keele JW Beattie C W | 1996 | Genome Res1996，6，： | 1 |
| 6 | The identification of crocetane in Australian crude oils 显示文摘 | Barber G J Griee K Bastow T P Alexander R Kagi R I | 2001 | Org Geochem2001，32，7： | 1 |
| 7 | ,Meningitis in pigs caused by Streptococcus suis - a speculative review 显示文摘 | Chanter N Jones P W Alexander T J L | 1993 | Vet Microbiol1993，36，： | 1 |
| 8 | Tetramethylnaphthalenes in crude oils显示文摘 | Alexander R Bastow T P Fisher S J | 1993 | Journal of Polycyclic Aromatic Compounds1993，3，： | 1 |
| 9 | Pentamethylnaphalenes and ralted compounds in sedimentary organic matter显示文摘 | Bastow T P Alexander R Sosrowidjojo I B | 1998 | Organic geochemistry1998，28，： | 1 |
| 10 | Interrelationship of knowledge, interest, and recall: Assessing a model of domain learning 显示文摘 | Alexander P Jetton T L | 1995 | Journal of Educational Psychology1995，87，4： | 1 |
| 11 | Distributions of methylated naphthalenes in crude oils:indicators of maturity,biodegradation and mixing显示文摘 | van Aarssen B G K Bastow T P Alexander R | 1999 | Organic Geochemistry1999，30，： | 1 |
| 12 | Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes 显示文摘 | ALEXANDER L K KAZUO M VLADIMIR P T | 1990 | FEBS Lett1990，268，1： | 1 |
| 13 | Analysis of crocetane in crude oils and sediments: Novel stationary phases for use in GC-MS 显示文摘 | Barber C J Bastow T P Grice K Alexander R Kagi R I | 2001 | Org Geochem2001，32，5： | 1 |
| 14 | Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction显示文摘 | Granger J P Alexander B T Llinas M T | 2001 | Hypertension2001，38，32： | 1 |
| 15 | The identification of crocetane in Australian crude oils显示文摘 | Barber C J Grice K Bastow T P Alexander R Kagi R I | 2001 | Org Geochem2001，32，7： | 1 |
| 16 | Characters of microencapsulated PCM slurry as a heat transfer fluid显示文摘 | Yasushi Yamagishi Hiromi Takeuchi Alexander T P | | 0，，04： | 1 |
| 17 | A protocol for patients with cardiovascular implantable devices undergoing magnetic resonance imaging(MRI):should defibrillation threshold testing be performed post-(MRI)显示文摘 | Burke P T Ghanbari H Alexander P B | 2010 | J Interv Card Electrophysiol2010，28，1： | 1 |
| 18 | Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction显示文摘 | Granger J P Alexander B T Llinas M T | 2001 | Hypertension2001，38，32： | 1 |
| 19 | TRII2, a trithothecene efflux pump from Fusarium sporotrichiodes: gene isolation and expression in yeast显示文摘 | Alexander N J McCormick S P Hohn T M | 1999 | Molecular & General Genetics1999，261，97： | 1 |
| 20 | Lime green light- emitting diode equipped yellow sticky card traps for monitoring whiteflies, aphids and fungus gnats in greenhouses 显示文摘 | Chu C C Chen T Y Alexander P J | 2004 | Ento- mologia2004，11，2： | 1 |
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