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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Some 7-Substituted 4-aminoquinoline derivatives显示文摘 | Alexander R S Henry F H | 1946 | J Am Chem Soc1946，18，： | 2 |
| 3 | Risk factors associated with major cerebrovascular complications after intracranial stenting显示文摘 | F Nahab M J. Lynn S E. Kasner M J. Alexander R Klucznik O O. Zaidat J Chaloupka H Lutsep S Barnwell M Mawad B Lane M I. Chimowitz | 2009 | Neurology2009，，23： | 2 |
| 4 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 5 | Hypothalamic serotonin in control of eating behavior, meal size, and body weight显示文摘 | LEIBOWITZ S F ALEXANDER J T | 1998 | Biol Psy1998，44，85： | 1 |
| 6 | Ultrasound imaging for lumbar punctures and epidural catheterizations:systematic review and meta-analysis显示文摘 | Shaikh F Brzezinski J Alexander S | 2013 | BMJ2013，346，： | 1 |
| 7 | Minimizing CVaR and VaR for a portfolio of derivatives 显示文摘 | ALEXANDER S COLEMAN T F LI Y | 2006 | Jour- nal of Banking & Finance2006，30，2： | 1 |
| 8 | Experiences from and prospects for the ESA convention显示文摘 | MARCO F ALEXANDER S | 2015 | German Journal of Air and Space Law2015，，2： | 1 |
| 9 | Analysis of neuropeptide Y induced feeding:dissociation of Y and Y receptor effects on natural 12 meal patterns显示文摘 | Leibowitz S F Alexander J T | | 0，，： | 1 |
| 10 | Strain localization in solution heat treated Al-Zn-Mg alloys显示文摘 | Alexander F Anders S Hans J R | 2001 | Materials Science and Engineering A2001，300，： | 1 |
| 11 | Lattice Boltzmann Thermohydrodynamics 显示文摘 | Alexander F J Chen S Sterling J D | 1993 | Phys Rev E1993，47，4： | 1 |
| 12 | Strain localization in solution heat treated Al-Zn-Mg alloys显示文摘 | Alexander F Anders S Huns J R | 2001 | Materials Science and Engineering2001，300，： | 1 |
| 13 | Continuous online auditing: a program of research显示文摘 | ALEXANDER K EPHRAIM F S MIKLOS A V | 1999 | Journal of Information Sys- tems1999，13，2： | 1 |
| 14 | Control of Exciton Migration Efficiency in Disordered J-Aggregates 显示文摘 | ALEXANDER V S IRINA I F ROMAN S G | 2010 | J Phys Chem C2010，114，2： | 1 |
| 15 | A fully automatable enzymatic method for DNA extraction from plant tissues显示文摘 | JEAN F M OLGA S LORENE A ALEXANDER V M ARKADY S | 2005 | BMC Plant Biology2005，23，： | 1 |
| 16 | The importance of predation,substrate and spatial rufugia in determining lotic insect distributions显示文摘 | Alexander S F Allan J D | 1984 | Oecologia1984，64，3： | 1 |
| 17 | Continuous online auditing: a program of research显示文摘 | Alexander K Ephraim F S Miklos A V | 1999 | Journal of Information Systems1999，13，2： | 1 |
| 18 | Minimizing CVaR and VaR for a portfolio of derivatives显示文摘 | Alexander S Coleman T F Li Y | 2006 | Journal of Banking b- Finance2006，30，2： | 1 |
| 19 | A criti- cal role for the evolutionarily conserved gonadotropin-releasing hormone II:Mediation of energy status and female sexual behav- ior显示文摘 | ALEXANDER S KAUFFMAN EMILIE F RISSMAN | 2004 | Endocrinol2004，145，8： | 1 |
| 20 | From Cellular cultures to cel lular spheroids:is impedance spectroscopy a viable tool for monitoring muhicellular spheroid (MCS) drug models? 显示文摘 | Alexander F A Price J D T Bhansali S | 2013 | IEEE Reviews In Biomedical Engineering2013，6，： | 1 |
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