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| 1 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 3 | Transgenic Myocardial Overexpression of Fibroblast Growth Factor-1 Increases Coronary Artery Density and Branching 显示文摘 | Borja F Alexandra B Swen W | 2000 | Circulation Research2000，87，： | 1 |
| 4 | Promoter proximal splice sites enhances transcription显示文摘 | Andre F Justin M O Alexandra B | | 0，，21： | 1 |
| 5 | Promoter proximal splice sites enhance transcription显示文摘 | ANDRE F JUSTIN M O ALEXANDRA B | 2002 | Genes Development2002，16，21： | 1 |
| 6 | Development of a heterogeneous chemiluminescent flow immunoassay for DDT and related compounds显示文摘 | Alexandra E B Fabiana F Sergei E | | 0，，01： | 1 |
| 7 | Polymeric materials with anti- microbial activity 显示文摘 | Alexandra M B Marta F G | 2012 | Prog Polym Sci2012，37，2： | 1 |
| 8 | Risk of Lung Cancer Associated With Occupational Exposure to Mineral Wools: Updating Knowledge From a French Population-Based Case–Control Study, the ICARE Study显示文摘 | Florence Guida Sophie Paget-Bailly Farida Lamkarkach Oumar Gaye Stéphane Ducamp Gwenn Menvielle Alexandra Papadopoulos Mireille Matrat Jo?lle Févotte Sylvie Cénée Diane Cyr Annie Schmaus Matthieu Carton Loredana Rado? Bénédicte Lap?tre-Ledoux Florence Mol | 2013 | Journal of Occupational and Environmental Medicine2013，，7： | 1 |
| 9 | Electrokinetic remediation of organochlorines in soil: Enhancement techniques and integration with other remediation technologies显示文摘 | Helena I G Celia D F Alexandra B R | 2012 | Chemosphere2012，87，10： | 1 |
| 10 | 查看详情显示文摘 | Alexandra M B Marta F G | | 0，，： | 1 |
| 11 | Prognostic value of cardiac troponin-I levels following catheter-based coronary interventions显示文摘 | Shmuel Fuchs Ran Kornowski Roxana Mehran Alexandra J Lansky Lowell F Satler Augusto D Pichard Kenneth M Kent Chester E Clark Gregg W Stone Martin B Leon | 2000 | The American Journal of Cardiology2000，，9： | 1 |
| 12 | Barley HVA 1 gene confers salt tolerance in R3 transgenic oat显示文摘 | Hesham F O Callista B R Alexandra N K | 2005 | Crop Science2005，45，6： | 1 |
| 13 | Gas permeation parameters of mixed matrix membranes based on the polymer of intrinsic microporosity PIM - 1 and the zeolitic imidazolate framework ZIF - 8 显示文摘 | Alexandra F B Martin P A Christopher R M | 2013 | Journal of Membrane Science2013，427，1： | 1 |
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