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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Toward covert iris biometric recog- nition: experimental results from the NICE contests显示文摘 | Proenea H Alexandre L A | 2012 | IEEE Transactions on Information Forensics and Security2012，7，2： | 1 |
| 3 | Human Nutrition and Metabolism 显示文摘 | Charlotte A Welma O Serena S Alexandre L | 2004 | American Society for Nutri- tional Sciences2004，，： | 1 |
| 4 | Aerodynamic and aeroelastic analyses on the CAARC standard tall build- ing model using numerical simulation显示文摘 | Alexandre L B Armando M A | 2009 | Computers and Structures2009，87，910： | 1 |
| 5 | Intradiscal injection of oxygenozone gas mixture for the treatment of cervical disc herniations显示文摘 | Alexandre A Coro L Azuelas A | 2005 | Acts Neurochir Suppl2005，92，： | 1 |
| 6 | Microsurgical treatment of lum- bosacral plexus injuries显示文摘 | Alexandre A Corb L Azuelos A | 2005 | Acta Neurochir Suppl2005，92，： | 1 |
| 7 | The Image Foresting Transform :Theory, Algorithms, and Applications 显示文摘 | Alexandre X F Jorge S Roberto de A L | 2004 | IEEEE Transactions on Pattern Analysis and Machine Intelligence2004，26，1： | 1 |
| 8 | Percutaneous nucleoplasty for discoradicular conflict 显示文摘 | Alexandre A Coro L Azuelos A | 2005 | Acta Neurochir2005，92，1： | 1 |
| 9 | An Analysis of destination choice for opaque airline products using multidimensional binary logit models 显示文摘 | Misuk L Alexandre K Laurie A G | 2013 | Transportation Research Part A2013，46，10： | 1 |
| 10 | Advantages and disadvantages of phytolith analysis for the reconstruction of Mediterranean vegetation : an assessment based on modern phytolith, pollen and botanical data (Luberoh, France ) 显示文摘 | Bremond L Alexandre A Vela E | 2004 | Review of Palaeobotany and Palynology2004，129，4： | 1 |
| 11 | Impact of surgical procedure and complications on outcome of third and subsequent kidney transplants显示文摘 | Alexandre L Dany A Timsit MO | 2007 | Transplantation2007，83，4： | 1 |
| 12 | Percutaneous nucleoplasty for disco radicular conflict显示文摘 | Alexandre A Coro L Azuelos A | 2005 | Acta Neurochir Suppl2005，92，1： | 1 |
| 13 | Percutaneous nucleoplasty for discoradicular confliet显示文摘 | Alexandre A Cor6 L Azuelos A | 2005 | Acta Neurochir2005，92，： | 1 |
| 14 | Treatment of symptomatic lumbar spinal degenerative pathologies by means of combined conservative biochemical treatments显示文摘 | Alexandre A Corò L Paradiso R | | 0，，： | 1 |
| 15 | Intradiscal injection of oxygen-ozone gas mixture for the treatment of cervical disc herniations显示文摘 | Alexandre A Coro L | 2005 | Acta Neurochirurgica2005，92，： | 1 |
| 16 | 1-n-Butyl-3- methylimidazolium tetrachloro-indate (BMI · InCl4 ) as a media for the synthesis of biodiesel from vegetable oils 显示文摘 | BRENNO A D S N MELQUIZEDEQUE B A ALEXANDRE A M L | 2007 | Journal of Catalysis2007，249，1： | 1 |
| 17 | Assessment of Lipid Compounds and Phosphorus in Mangrove Sedi- ments of Santa Catarina Island, SC, Brazil 显示文摘 | Mater L Alexandre M R Hansel F A | 2004 | Journal of the Brazilian Chemical Society2004，15，5： | 1 |
| 18 | Anti-inflammatory effect of quereetin-loaded microemulsion in the airways allergic inflammatory model in mice显示文摘 | Alexandre P Rogerio A Cristiana L | 2010 | Pharmacol Res2010，61，： | 1 |
| 19 | Intradiscal injection of oxygenozone gasmixture for the treatment of cervical disherniations 显示文摘 | Alexandre A Coro L | 2005 | AetaNeurochirurgica2005，，： | 1 |
| 20 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HCI solution 显示文摘 | VANESSA V T ROBERTO S A CAMILA F TATIANA L F CARLOS R ALEXANDRE G T ELIANE D | 2011 | Corrosion Science2011，53，： | 1 |
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