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| 1 | Association between cag-pathogenicity island in Helicobacter pylori isolates from peptic ulcer,gastric carcinoma,and non-ulcer dyspepsia subjects with histological changes显示文摘AIM: To investigate the presence of the cay-pathogenicity island and the associated histological damage caused by strains with complete cay-PAI and with partial deletions in correlation to the disease status.METHODS: We analyzed the complete cag-PAI of 174representative Helicobacter pylori (H pylori ) clinical isolates obtained from patients with duodenal ulcer,gastric ulcer, gastric cancer, and non-ulcer dyspepsia using eight different oligonucleotide primers viz cagA1,cagA2, cagAP1, cagAP2, cagE, cagT, LEC-1, LEC-2spanning five different loci of the whole cag-PAI by polymerase chain reaction (PCR).RESULTS: The complete screening of the genes comprising the cag-PAI showed that larger proportions of subjects with gastric ulcer (97.8%) inhabited strains with complete cag-PAI, followed by gastric cancer (85.7%),non-ulcer dyspepsia (7.1%), and duodenal ulcer (6.9%),significant differences were found in the percentagedistribution of the genes in all the clinical groups studied.It was found that strains with complete cag-PAI were able to cause severe histological damage than with the partially deleted ones.CONCLUSION: The cay-PAI is a strong virulent marker in the disease pathogenesis as it is shown that a large number of those infected with strain with complete cag-PAI had one or the other of the irreversible gastric pathologies and interestingly 18.5% of them developed gastric carcinoma. The presence of an intact cayPAI correlates with the development of more severe pathology, and such strains were found more frequently in patients with severe gastroduodenal disease. Partial deletions of the cag-PAI appear to be sufficient to render the organism less pathogenic. | Mahaboob Ali Aleem A Khan Santosh K Tiwari Niyaz Ahmed L Venkateswar Rao CM Habibullah | 2005 | World Journal of Gastroenterology2005，11，43： | 15 |
| 2 | Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Christopher J L Murray Theo Vos Rafael Lozano Mohsen Naghavi Abraham D Flaxman Catherine Michaud Majid Ezzati Kenji Shibuya Joshua A Salomon Safa Abdalla Victor Aboyans Jerry Abraham Ilana Ackerman Rakesh Aggarwal Stephanie Y Ahn Mohammed K Ali Mohammad A | 2012 | The Lancet . 2012 (9859)2012，，9859： | 2 |
| 3 | Ca^2+ /calmodulin regulates salicylic-add-mediated plant immunity显示文摘 | Du L Ali G S Smons K A | 2009 | Nature2009，457，： | 1 |
| 4 | Photophysics and dynamics of coumarin laser dyes and their analytical implications显示文摘 | M S A Abdel-Mottaleb M S Antonious M M Abo Ali L F M Ismail B A El-Sayed A M K Sherief | 1992 | Proceedings of the Indian Academy of Sciences - Chemical Sciences1992，，2： | 1 |
| 5 | A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties 显示文摘 | Ali S S Hardt J I Quick K L Kim-Han J S Erlanger B F H uang T T | 2004 | Free Radic Biol Med2004，37，： | 1 |
| 6 | A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice 显示文摘 | Quick K L Ali S S Arch R Xiong C Wozniak D Dugan L L | 2008 | Neurobiol Aging2008，29，： | 1 |
| 7 | A study on a hybrid actuator显示文摘 | Ali K Dulger L C | 2000 | Mechanism and Machine Theory2000，35，： | 1 |
| 8 | Inte grated learning particle swarm optimizer for global optimization显示文摘 | Sabat Samrat L Ali Layak Udgata Siba K | 2011 | Applied Soft Computing2011，11，1： | 1 |
| 9 | Risk factors and prevalence of diabetic peripheral neuropathy :a study of type 2 diabetic outpatients in Ban- gladesh显示文摘 | Morkrid K Ali L Hussain A | 2010 | Int J Diabetes Dev Ctries2010，30，1： | 1 |
| 10 | Interactions of tropospheric CO2 and O3 enrichments and moisture variations on microbial biomass and respiration in soil 显示文摘 | Islam K R Mulchi C L Ali A A | 2000 | Global Change Biology2000，6，： | 1 |
| 11 | Chemical struc- ture of asphahene in heavy crude oils investigated by NMR显示文摘 | ALI L H AL-GHANNAM K A AL-RAWI J M | 1990 | Fuel1990，69，4： | 1 |
| 12 | Investigations into asphaltenes in heavy crude oils显示文摘 | ALI L H AL-GHANNAM K A | 1981 | Fuel1981，60，11： | 1 |
| 13 | Chemical structure of asphaltenes in heavy crude oils investigated by NMR显示文摘 | ALI L H AL-GHANNAM K A AL-RAWI J M | 1990 | Fuel1990，69，4： | 1 |
| 14 | Better use of water hyacinth for fuel, manure and pollution free environment显示文摘 | ALI N CHAUDHARY B L KHANDELWAL S K | 2004 | Indian J Environ Prot2004，24，： | 1 |
| 15 | Collapse of current gain in multi-finger heterojunction bipolar transistors: its substrate temperature dependence, instability criteria and modeling 显示文摘 | WILLIAM L ALI K | 1994 | IEEE Transaction on Electron Devices1994，41，10： | 1 |
| 16 | Treatment of Graves' disease: 300 cases显示文摘 | Hadj Ali I Khiari K Cherif L | 2004 | Presse Med2004，33，1： | 1 |
| 17 | Effect of microvoid formation on the tensile properties of dual-phase steel显示文摘 | Ahmad E Manzoor T Ali K L | 2000 | Journal of Materials Engineering and Performance2000，9，： | 1 |
| 18 | Tissue and stressorspecific differ rential expression of two HSC70 genes in carp 显示文摘 | Ali K Dorgai L Abraham M | 2003 | Biochmical and Biophysical Research Comunications2003，307，3： | 1 |
| 19 | Ca2+/calmodulin regulates salicylic-acid-mediated plant immunity 显示文摘 | Du L Ali G S Simons K A | 2009 | Nature2009，457，7233： | 1 |
| 20 | Tuning of HOMO levels of carbazole derivatives:newmolecules for blue OLED 显示文摘 | Agarwal N Nayak P K Ali F Patankar M P Narasimhan K L Periasamy N | 2011 | Synthetic Metals2011，161，56： | 1 |
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