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| 1 | Pathogenesis and clinical management of Helicobacter pylori gastric infection显示文摘Helicobacter pylori(H.pylori)is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide.However,its prevalence varies among different geographic areas,and is influenced by several factors.The infection can be acquired by means of oral-oral or fecal-oral transmission,and the pathogen possesses various mechanisms that improve its capacity of mobility,adherence and manipulation of the gastric microenvironment,making possible the colonization of an organ with a highly acidic lumen.In addition,H.pylori presents a large variety of virulence factors that improve its pathogenicity,of which we highlight cytotoxin associated antigen A,vacuolating cytotoxin,duodenal ulcer promoting gene A protein,outer inflammatory protein and gamma-glutamyl transpeptidase.The host immune system,mainly by means of a Th1-polarized response,also plays a crucial role in the infection course.Although most H.pylori-positive individuals remain asymptomatic,the infection predisposes the development of various clinical conditions as peptic ulcers,gastric adenocarcinomas and mucosa-associated lymphoid tissue lymphomas.Invasive and non-invasive diagnostic methods,each of them with their related advantages and limitations,have been applied in H.pylori detection.Moreover,bacterial resistance to antimicrobial therapy is a major challenge in the treatment of this infection,and new therapy alternatives are being tested to improve H.pylori eradication.Last but not least,the development of effective vaccines against H.pylori infection have been the aim of several research studies. | Breno Bittencourt de Brito Filipe Ant?nio Fran?a da Silva Aline Silva Soares Vinícius Afonso Pereira Maria Luísa Cordeiro Santos Mariana Miranda Sampaio Pedro Henrique Moreira Neves Fabrício Freire de Melo | 2019 | World Journal of Gastroenterology2019，25，37： | 84 |
| 2 | Therapeutic potential of periodontal ligament stem cells显示文摘Inflammatory periodontal disease known as periodontitis is one of the most common conditions that affect human teeth and often leads to tooth loss.Due to the complexity of the periodontium,which is composed of several tissues,its regeneration and subsequent return to a homeostatic state is challenging with the therapies currently available.Cellular therapy is increasingly becoming an alternative in regenerative medicine/dentistry,especially therapies using mesenchymal stem cells,as they can be isolated from a myriad of tissues.Periodontal ligament stem cells(PDLSCs)are probably the most adequate to be used as a cell source with the aim of regenerating the periodontium.Biological insights have also highlighted PDLSCs as promising immunomodulator agents.In this review,we explore the state of knowledge regarding the properties of PDLSCs,as well as their therapeutic potential,describing current and future clinical applications based on tissue engineering techniques. | Aline Queiroz Emmanuel Albuquerque-Souza Leticia Miquelitto Gasparoni Bruno Nunes de França Cibele Pelissari Marília Trierveiler Marinella Holzhausen | 2021 | World Journal of Stem Cells2021，13，6： | 5 |
| 3 | Percutaneous radiofrequency ablation for early hepatocellular carcinoma: Risk factors for survival显示文摘AIM: To evaluate outcomes of radiofrequency ablation(RFA) therapy for early hepatocellular carcinoma(HCC) and identify survival- and recurrence-related factors. METHODS: Consecutive patients diagnosed with early HCC by computed tomography(CT) or magnetic resonance imaging(MRI)(single nodule of ≤ 5 cm, or multi-(up to 3) nodules of ≤ 3 cm each) and who underwent RFA treatment with curative intent between January 2010 and August 2011 at the Instituto do Cancer do Estado de S o Paulo, Brazil were enrolled in the study. RFA of the liver tumors(with 1.0 cm ablative margin) was carried out under CT-fluoro scan and ultrasonic image guidance of the percutaneous ablation probes. Procedure-related complications were recorded. At 1-mo post-RFA and 3-mo intervals thereafter, CT and MRI were performed to assess outcomes of complete response(absence of enhancing tissue at the tumor site) or incomplete response(enhancing tissue remaining at the tumor site). Overall survival and diseasefree survival rates were estimated by the Kaplan-Meier method and compared by the log rank test or simple Cox regression. The effect of risk factors on survival was assessed by the Cox proportional hazard model. RESULTS: A total of 38 RFA sessions were performed during the study period on 34 patients(age in years: mean, 63 and range, 49-84). The mean follow-up time was 22 mo(range, 1-33). The study population showed predominance of male sex(76%), less severe liver disease(Child-Pugh A, n = 26; Child-Pugh B, n = 8), and single tumor(65%). The maximum tumor diameters ranged from 10 to 50 mm(median, 26 mm). The initial(immediately post-procedure) rate of RFAinduced complete tumor necrosis was 90%. The probability of achieving complete response was significantly greater in patients with a single nodule(vs patients with multi-nodules, P = 0.04). Two patients experienced major complications, including acute pulmonary edema(resolved with intervention) and intestinal perforation(led to death). The 1- and 2-year overall survival rates were 82% and 71%, respectively. Sex, tumor size, initial response, and recurrence status influenced survival, but did not reach the threshold of statistical significance. Child-Pugh class and the model for end-stage liver disease score were identified as predictors of survival by simple Cox regression, but only Child-Pugh class showed a statistically significant association to survival in multiple Cox regression analysis(HR = 15; 95%CI: 3-76 mo; P = 0.001). The 1-and 2-year cumulative disease-free survival rates were 65% and 36%, respectively. CONCLUSION: RFA is an effective therapy for local tumor control of early HCC, and patients with preserved liver function are the best candidates. | Luciana Kikuchi Marcos Menezes Aline L Chagas Claudia M Tani Regiane SSM Alencar Marcio A Diniz Venncio AF Alves Luiz Augusto Carneiro D’Albuquerque Flair José Carrilho | 2014 | World Journal of Gastroenterology2014，20，6： | 5 |
| 4 | Personalized medicine in gastric cancer:Where are we andwhere are we going?显示文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer. | Alexandre A Jácome Anelisa K Coutinho Enaldo M Lima Aline C Andrade JoséSebastião dos Santos | 2016 | World Journal of Gastroenterology2016，22，3： | 2 |
| 5 | Efficacy of oral and intravenous artesunate in male Tanzanian adults with Plasmodium falcilparum malaria and in vitro susceptibility to artemisinin, chloroquine, and mefloquine显示文摘 | Alin MH Kihamia CM Bjorkman A | 1995 | Am J Trop Med Hyg1995，53，6： | 1 |
| 6 | Metabolic andnutritional profile of obese adolescents with nonalcoholic fattyliver disease显示文摘 | De-Piano Aline Prado W L Caranti D A | 2007 | J Pediatr Gastroenterol Nutr2007，44，4： | 1 |
| 7 | Inhibition of immune-mediated concanavalin a-induced liver damage by free-radical scavengers显示文摘 | Shirin H Aeed H Alin A | 2010 | Dig Dis Sci2010，55，2： | 1 |
| 8 | Comparative analysis of chaos control methods : A mechanical system case study 显示文摘 | Aline S Marcelo A | 2011 | International Journal of Non-Linear Mechanics2011，46，8： | 1 |
| 9 | Frequent deletions and down regulation of micro-RNA genes miR15 and miR16 at 13ql4 in chronic lymphocytic leukemia 显示文摘 | ALIN G A DUMITRU C D SHIMIZU M | 2002 | Proc Natl Acad Sci USA2002，99，15： | 1 |
| 10 | Effect of the treatment with achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by trypanosoma evansi显示文摘 | Guilherme M. Do Carmo Matheus D. Baldissera Rodrigo A. Vaucher Virginia Cielo Rech Camila B. Oliveira Michele Rorato Sagrillo Aline A. Boligon Margareth L. Athayde Marta P. Alves Raqueli T. Fran?a Sonia T.A. Lopes Claiton I. Schwertz Ricardo E. Mendes Sil | 2014 | Experimental Parasitology2014，，： | 1 |
| 11 | Removal of chromium from aqueous solution by complexation - ultrafiltration using a water- soluble macroligand显示文摘 | Aline A Bounatiro N Cherif A T | 2001 | Wat Res2001，35，9： | 1 |
| 12 | Lymphangioma of the esophagus treated with endoscopic submucosal resection 显示文摘 | Sushil A Aline PC Metin O | 2007 | J Gastroenterol Hepatol2007，22，2： | 1 |
| 13 | Increased Adipose Tissue Expression of Hepcidin in Severe Obesity Is Independent From Diabetes and NASH显示文摘 | Soumeya Bekri Philippe Gual Rodolphe Anty Nathalie Luciani Monsef Dahman Bala Ramesh Antonio Iannelli Aline Staccini–Myx Dominique Casanova Imed Ben Amor Marie–Christine Saint–Paul Pierre–Michel Huet Jean–Louis Sadoul Jean Gugenheim Surjit Kaila S. Srai A | 2006 | Gastroenterology2006，，3： | 1 |
| 14 | Frequent deletions and down reguJation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia显示文摘 | Alin G A Dumitru C D Shimizu M | 2002 | Proc Natl Acad Sci USA2002，99，15： | 1 |
| 15 | Video super resolution using generalized Gaussian markov random fields 显示文摘 | CHEN J JOSE N Y ALIN A | 2012 | IEEE Sig Proc Lett2012，19，2： | 1 |
| 16 | Diversity of Cultivated Endophytic Bacteria from Sugarcane:Genetic and Biochemical Characterization of Burkholderia cepacia Complex Isolates显示文摘 | RODRIGO M ALINE A PIZZIRANI K | 2007 | Applied and Environmental Microbiology2007，22，73： | 1 |
| 17 | Dimethylsulphoxide and other biogenie sulphur compounds in the Galapagos Plume 显示文摘 | HATTON A D TURNER S M M ALIN G | 1998 | Deep-Sea Research Ⅱ1998，45，： | 1 |
| 18 | Spatial patterns of photosynthesis in thin-and thick-leaved epiphytic orchids:unravelling C3-CAM plasticity in an organ-compartmented way显示文摘 | IVhria A R Alejandra M Aline B C | 2013 | Annals of Botany2013，112，： | 1 |
| 19 | Muscle strengthening is not effective in children and adolescents with cerebral palsy a systemat- ic review显示文摘 | Aline S Jane MB Louise A | 2009 | Australian Journal of Physiotherapy2009，55，1： | 1 |
| 20 | Reductive sulfur extrusion reaction of 2, 1,3-benzothiadiazole compounds: a new methodology using NaBH4/CoCl2 · s H2O (eat) as the reducing system显示文摘 | Brenno A DaSilveira Neto Aline S | 2005 | Tetrahedron Letters2005，，46： | 1 |
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