|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Phenolic composition and inhibitory activity of Mangifera indica and Mucuna urens seeds extracts against key enzymes linked to the pathology and complications of type 2 diabetes显示文摘Objective:To investigate the phenolic compounds composition and the inhibitory activity of Mangifera indica(M.indica) and Mucuna urens(M.urens) seeds extracts against some key enzymes(-amylase,-glucosidasc and aldose reductase) implicated in the pathology and complications of type 2 diabetes in vitro.Methods:Reverse phase chromatographic quantification of the major flavonoids and phenolic acids in the seeds extracts was carried out using high performance liquid chromatography coupled with diode array detection.The inhibitory activities of the seeds extracts against-amylase and-glucosidase were estimated using soluble starch and p-nitrophenylglucopyranosidc as their respective substrates.Inhibition of aldose reductase activity by the extracts was assayed using partially purified lens homogenate of normal male rat as source of enzyme;inhibition of Fe^(2+)-induced lipid peroxidation by extracts was tested in rat pancreas homogenate.Results:The chromatography result revealed that extracts of both seeds had appreciable levels of some major flavonoids and phenolic acids of pharmacological importance,including gallic acid,chlorogenic acid,caffeic acid,ellagic acid,catechin,rutin,quercitrin.quercetin and kaempferol.Extracts of both seeds effectively inhibited-amylase,-glucosidase and aldose reductase activities in a dose-dependent manner,having inhibitory preference for these enzymes in the order of aldose reductase>-glucosidase>-amylase.With lower half-maximal inhibitory concentrations(IC50)against-amylase,-glucosidase,and aldose reductase,M.indica had stronger inhibitory potency against these enzymes than M.urens.Extracts of both seeds also inhibited Fe2+-induced lipid peroxidation in a dose-dependent pattern,with M.indica being more potent than M.urens.Conclusions:The results obtained provide support for a possible use of M.indica and M.urens seeds in managing hyperglycemia and preventing the complications associated with it in type 2diabetes. | Emmanuel Anyachukwu Irondi Ganiyu Oboh Afolabi Akintunde Akindahunsi Aline Augusti Boligon Margareth Linde Athayde | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，11： | 4 |
| 2 | Phenolics extract of Tetrapleura tetraptera fruit inhibits xanthine oxidase and Fe^2+-induced lipid peroxidation in the kidney,liver,and lungs tissues of rats in vitro显示文摘The phenolics composition and inhibitory activity of Tetrapleura tetraptera fruit extract on xanthine oxidase(XO)and Fe2+-induced lipid peroxidation in the kidney,liver and lungs tissues of rats were evaluated in vitro.Phenolics(flavonoids and phenolic acids)were quantified using reverse-phase high performance liquid chromatrography coupled with diode array detection(HPLC-DAD).The XO and Fe2+-induced lipid peroxidation inhibitory abilities of the extract were evaluated using spectrophotometric methods.The extract contained some flavonoids and phenolic acids,including catechin,epicatechin,rutin,quercetin,luteolin,apigenin;gallic,chlorogenic,caffeic and ellagic acids that are beneficial to health.The extract inhibited XO in the kidney,liver and lungs tissues in a dose-dependent manner.The half-maximal inhibitory concentrations(IC50)of the extract on XO from the tissues varied significantly(P<0.05),and were in the order of liver>kidney>lungs.The extract also inhibited Fe2+-induced lipid peroxidation in a dose-dependent pattern,having IC50 in the order of liver>lungs>kidney.T.tetraptera fruit extract could be a promising nutraceutical for preventing and managing hyperuricaemia and the associated disease conditions,due to its ability to inhibit XO;this bioactivity is attributable to combined effect of its flavonoids and phenolic acids. | Emmanuel Anyachukwu Irondi Ganiyu Oboh Samson Olalekan Agboola Aline Augusti Boligon Margareth Linde Athayde | 2016 | Food Science and Human Wellness2016，5，1： | 3 |
| 3 | Intrahepatic IL-8 producing Foxp3 + CD4 + regulatory T cells and fibrogenesis in chronic hepatitis C<!-- Doctopic: VH -->显示文摘 | Bettina Langhans Benjamin Kr?mer Marcell Louis Hans Dieter Nischalke Robert Hüneburg Andrea Staratschek-Jox Margarethe Odenthal Steffen Manekeller Michael Schepke J?rg Kalff Hans-Peter Fischer Joachim L. Schultze Ulrich Spengler | 2013 | Journal of Hepatology2013，，2： | 1 |
| 4 | Inducible expression of tissue factor in small-cell lung cancer:impact on morphology and matrix met alloproteinase secretion显示文摘 | NICOLE H MARGARETHE II RAINER S | 2012 | Canner Res Clin Onca12012，138，4： | 1 |
| 5 | The use of lidocaine as an anti-inflammatory substance: A systematic review显示文摘 | Hugo Cesar Pinto Marques Caracas José Vinícius Bolognesi Maciel Patrícia Machado Rodrigues e Silva Martins Margareth Maria Gomes de Souza Lucianne Cople Maia | 2008 | Journal of Dentistry2008，，2： | 1 |
| 6 | TP53 mutation and p53 overexpression for prediction of response to neoadjuvant treatment in breat cancer patients显示文摘 | Daniela KE Carmen L Margarethe R | 2000 | Clin Cancer Res2000，6，1： | 1 |
| 7 | CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers 显示文摘 | Susanne P Karin B Margarethe W | 2002 | J Leukoc Biol2002，72，： | 1 |
| 8 | Effect of the treatment with achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by trypanosoma evansi显示文摘 | Guilherme M. Do Carmo Matheus D. Baldissera Rodrigo A. Vaucher Virginia Cielo Rech Camila B. Oliveira Michele Rorato Sagrillo Aline A. Boligon Margareth L. Athayde Marta P. Alves Raqueli T. Fran?a Sonia T.A. Lopes Claiton I. Schwertz Ricardo E. Mendes Sil | 2014 | Experimental Parasitology2014，，： | 1 |
| 9 | Antioxidant activities of flavonol derivatives from the leaves and stem bark of Scutia buxifolia Reiss显示文摘 | Aline Augusti Boligon Romaiana Picada Pereira Andriéli Cassel Feltrin Michel Mansur Machado Vanessa Janovik Jo?o Batista Teixeira Rocha Margareth Linde Athayde | 2009 | Bioresource Technology2009，，24： | 1 |
| 10 | Activity of Angiotensin‐Converting Enzyme After Treatment with L‐Arginine in Renovascular Hypertension显示文摘 | Sonia A. Gouvea Nazaré S. Bissoli Margareth R. Moysés Maria A. Cicilini José G. P. Pires Glaucia R. Abreu | 2004 | Clinical and Experimental Hypertension2004，，6： | 1 |
| 11 | Towards mosquito sterile insect technique programmes: Exploring genetic, molecular, mechanical and behavioural methods of sex separation in mosquitoes显示文摘 | Jeremie R.L. Gilles Marc F. Schetelig Francesca Scolari Franti?ek Marec Margareth L. Capurro Gerald Franz Kostas Bourtzis | 2014 | Acta Tropica2014，，： | 1 |
| 12 | Executive turnover in the stock option backdating wave: The impact of social context显示文摘 | Margarethe F. Wiersema Yan (Anthea) Zhang | 2012 | Strat. Mgmt. J2012，，5： | 1 |
| 13 | A novel trypsin Kazal-type inhibitor from Aedes aegypti with thrombin coagulant inhibitory activity显示文摘 | Renata M.O. Watanabe Tatiane S. Soares Karen Morais-Zani Anita M. Tanaka-Azevedo Ceres Maciel Margareth L. Capurro Ricardo J.S. Torquato Aparecida S. Tanaka | 2010 | Biochimie2010，，8： | 1 |
| 14 | Hydrolysis of Atlantic salmon ( Salmo salar) rest raw materials - Effect of raw material and processing on composition, nutritional value, and potential bioactive peptides in the hydrolysates 显示文摘 | Margareth Opheima Rasa SliVzyte | 2015 | Process Biochemistry2015，50，： | 1 |
| 15 | Maytenus erythroxylon Reissek(Celastraceae) ethanol extract presents antidiarrheal activity via antimotility and antisecretory mechanisms显示文摘AIM To investigate the acute toxicity,phytochemical profile,antidiarrheal activity and mechanisms of action of Maytenus erythroxylon(M.erythroxylon)ethanol extract.METHODS A castor oil-induced diarrhea model was used to evaluate antidiarrheal activity.Intestinal transit and gastric emptying protocols were used to evaluate a possible antimotility effect.KATP channels,nitric oxide,presynapticα2-adrenergic and tissue adrenergic receptors were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory mechanisms.RESULTS All tested doses of the extract(62.5,125,250 and 500 mg/kg)possessed antidiarrheal activity,with a significant decrease of the evacuation index.This activity is possibly related to a reduced gastric emptying(125,250 and 500 mg/kg)and to a decreased percentage of intestinal transit for all tested doses.That last effect seems to be modulated by nitric oxide,KATP channels and tissue adrenergic receptors.Besides,the extract also presented antisecretory effect due to a decrease of intestinal fluid accumulation.CONCLUSION The antidiarrheal effect of M.erythroxylon found in this study involves antimotility and antisecretory mechanisms that may be attributed to the chemical compounds found in this species:saponins,flavonoids,tannins,triterpenes and steroids. | Rodrigo de Oliveira Formiga Zelma Glebya Maciel Quirino Margareth de Fátima Formiga Melo Diniz Alexsandro Fernandes Marinho Josean Fechine Tavares Leonia Maria Batista | 2017 | World Journal of Gastroenterology2017，23，24： | 1 |
| 16 | Metformin Improves Vascular Function in Insulin-Resistant Rats显示文摘 | Prasad V. G. Katakam Michael R. Ujhelyi Margarethe Hoenig Allison W. Miller | 2000 | Hypertension: Journal of the American Heart Association ( Part )2000，，1： | 1 |
| 17 | The impact of social support and sense of coherence on health-related quality of life among nursing home residents—A questionnaire survey in Bergen, Norway显示文摘 | Jorunn Drageset Geir Egil Eide Harald A. Nygaard Margareth Bondevik Monica W. Nortvedt Gerd Karin Natvig | 2008 | International Journal of Nursing Studies2008，，1： | 1 |
| 18 | Adiponectin inhibits steatotic CD95/Fas up-regulation by hepatocytes: Therapeutic implications for hepatitis C显示文摘 | Inga Wedemeyer Lars P. Bechmann Margarethe Odenthal Christoph Jochum Guido Marquitan Uta Drebber Guido Gerken Robert K. Gieseler Hans P. Dienes Ali Canbay | 2008 | Journal of Hepatology2008，，1： | 1 |
| 19 | Sucrose fer- mentation by brazilian ethanol production yeasts in media containing structurally complex nitrogen sources显示文摘 | MESSIAS NO MARGARETH B EDUARDO M C | 2009 | J Inst Brewing2009，，115： | 1 |
| 20 | Mechanical Properties and Bond Strength of Glassionomer Cements显示文摘 | LUCIA COELHO GARGIA PEREIRA MARGARETH CALVO PESSUTTI NUNES | 2002 | J Adhes Dent2002，4，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员