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| 1 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 2 | Telomere shortening in atherosclerosis显示文摘 | Nilesh J Samani Rachel Boultby Robert Butler John R Thompson Alison H Goodall | 2001 | The Lancet2001，，9280： | 1 |
| 3 | Postoperative adhesions: Ten-year follow-up of 12,584 patients undergoing lower abdominal surgery显示文摘 | Michael C. Parker Harold Ellis Brendan J. Moran Jeremy N. Thompson Malcolm S. Wilson Don Menzies Alistair McGuire Adrian M. Lower Robert J. S. Hawthorn Fiona O’Brien Scot Buchan Alison M. Crowe | 2001 | Diseases of the Colon & Rectum2001，，6： | 1 |
| 4 | Recent developments in the aerobic oxidation of alcohols显示文摘 | Bi-Zeng Zhan Alison Thompson | 2004 | Tetrahedron2004，，13： | 1 |
| 5 | Regulation and manipulation of ABA biosynthesis in roots显示文摘 | Barry J Mulholl Alison C Jackson | 2007 | Plant Cell and Environment2007，30，： | 1 |
| 6 | Adhesion-related hospital readmissions after abdominal and pelvic surgery: a retrospective cohort study显示文摘 | Harold Ellis Brendan J Moran Jeremy N Thompson Michael C Parker Malcolm S Wilson Don Menzies Alistair McGuire Adrian M Lower Robert JS Hawthorn Fiona O’Brien Scot Buchan Alison M Crowe | 1999 | The Lancet1999，，9163： | 1 |
| 7 | The psychosis threshold in Ultra High Risk (prodromal) research: Is it valid?显示文摘 | Alison R. Yung Barnaby Nelson Andrew Thompson Stephen J. Wood | 2010 | Schizophrenia Research2010，，1： | 1 |
| 8 | Abscisic acid biosynthesis in tomato: regulation of zeaxanthin epoxidase and 9-cis-epoxycarotenoid dioxygenase mRNAs by light/dark cycles, water stress and abscisic acid显示文摘 | Andrew J. Thompson Alison C. Jackson Rachel A. Parker David R. Morpeth Alan Burbidge Ian B. Taylor | 2000 | Plant Molecular Biology2000，，6： | 1 |
| 9 | Abscisic acid biosynthesis in tomato: regulation of zeaxanthin epoxidase and 9-cis-epoxycarotenoid dioxygenase mRNAs by light/dark cycles, water stress and abscisic acid显示文摘 | Andrew J. Thompson Alison C. Jackson Rachel A. Parker David R. Morpeth Alan Burbidge Ian B. Taylor | 2000 | Plant Molecular Biology2000，，6： | 1 |
| 10 | Age-related impairment of esophagogastric junction relaxation and bolus flow time显示文摘AIM To investigate the functional effects of abnormal esophagogastric(EGJ) measurements in asymptomatic healthy volunteers over eighty years of age. METHODS Data from 30 young controls(11 M, mean age 37 ± 11 years) and 15 aged subjects(9 M, 85 ± 4 years) were compared for novel metrics of EGJ-function: EGJcontractile integral(EGJ-CI), 'total' EGJ-CI and bolus flow time(BFT). Data were acquired using a 3.2 mm, 25 pressure(1 cm spacing) and 12 impedance segment(2 cm) solid-state catheter(Unisensor and MMS SolarGI system) across the EGJ. Five swallows each of 5 m L liquid(L) and viscous(V) bolus were analyzed. Mean values were compared using Student's t test for normally distributed data or Mann Whitney U-test when non-normally distributed. A P value < 0.05 was considered significant.RESULTS EGJ-CI at rest was similar for older subjects compared to controls. 'Total' EGJ-CI, measured during liquid swallowing, was increased in older individuals when compared to young controls(O 39 ± 7 mm Hg.cm vs C 18 ± 3 mm Hg.cm; P = 0.006). For both liquid and viscous bolus consistencies, IRP4 was increased(L: 11.9 ± 2.3 mm Hg vs 5.9 ± 1.0 mm Hg, P = 0.019 and V: 14.3 ± 2.4 mm Hg vs 7.3 ± 0.8 mm Hg; P = 0.02) and BFT was reduced(L: 1.7 ± 0.3 s vs 3.8 ± 0.2 s and V: 1.9 ± 0.3 s vs 3.8 ± 0.2 s; P < 0.001 for both) in older subjects, when compared to young. A matrix of bolus flow and presence above the EGJ indicated reductions in bolus flow at the EGJ occurred due to both impaired bolus transport through the esophageal body(i.e., the bolus never reached the EGJ) and increased flow resistance at the EGJ(i.e., the bolus retained just above the EGJ).CONCLUSION Bolus flow through the EGJ is reduced in asymptomatic older individuals. Both ineffective esophageal bolus transport and increased EGJ resistance contribute to impaired bolus flow. | Charles Cock Laura K Besanko Carly M Burgstad Alison Thompson Stamatiki Kritas Richard Heddle Robert JL Fraser Taher I Omari | 2017 | World Journal of Gastroenterology2017，23，15： | 0 |
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