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| 1 | 香港华人妇女产后抑郁危险因素的前瞻性研究显示文摘目的:产后抑郁是一种常见的精神障碍,对产妇、新生儿和其它家庭成员导致广泛的伤害。产后抑郁的病因学研究大多是基于西方样本,对其中的社会文化原因也缺乏实证研究。本研究从人口学、心理社会及种族文化因素等方面探讨中国妇女产后抑郁症状学的决定因素。方法:在大学附属综合医院产前门诊连续收集登记的中国孕妇959例,从她们第一次产前检查开始评估(基线),以后分别在孕期的最后3个月、产后即刻和产后3个月时评估。调查涉及的危险因素分6个方面:人口学和社会经济背景,躯体疾病及精神疾病病史, 产前抑郁情绪,围生期应激源,人际关系,和种族文化环境。采用等级回归进行分析。因变量是产后3个月时的抑郁评分。结果:决定产后抑郁症状学的因素有:目前的生活事件,缺乏社会支持,婚姻不满意,既往有故意自伤史,以及产前存在抑郁情绪。婆媳关系不好和没有陪月在产后阶段也与抑郁评分高有关联。结论:西方研究所确立的产后抑郁危险因素大体适用于中国妇女。产褥期的社会文化特点同样对产妇情绪有影响。 | Dominic TS Lee Alexander SK Yip Sandra SM Chan Fiona FY Lee Tony YS Leung Tony KH Chung | 2005 | 中国心理卫生杂志2005，19，9： | 50 |
| 2 | Following a TRAIL: Update on a ligand and its five receptors显示文摘Identification of tumour necrosis factor apoptosis inducing ligand (TRAIL), a TNF family ligand, sparked a torrent of research, following an initial observation that it could kill tumour cells, but spare normal cells. Almost a decade after its discovery, and with five known receptors, the true physiological role of TRAIL is still debated and its anti-tumorigenic properties limited by potential toxicity. This review takes a comprehensive look at the story of this enigmatic ligand, addressing its remaining potential as a therapeutic and providing an overview of the TRAIL receptors themselves. | Fiona C. KIMBERLEY Gavin R. SCREATON | 2004 | Cell Research2004，14，5： | 26 |
| 3 | 经济发展对中国农村家庭时间分配性别模式的影响显示文摘本文运用中国健康与营养调查数据,研究了1991~2006年中国农村的经济发展对农户家庭内部时间分配的性别分工和劳动负担的影响。结果表明,中国农村男性和女性的时间分配都表现出从家庭经营向工资劳动转移的趋势,女性的变化幅度更大一些,而经济发展对男性和女性的家务劳动时间的影响都不显著。研究还发现,经济发展指标的变化与成年男性和女性绝对工作负担的增加以及女性在家庭中相对工作负担的增加显著正相关。 | 畅红琴 董晓媛 Fiona MacPhail | 2009 | 中国农村经济2009，，12： | 22 |
| 4 | 体质指数和腰围对浙江地区成年人糖尿病发生影响的前瞻性研究显示文摘目的 探讨BMI和腰围对成年人糖尿病发病的影响。方法 使用"中国慢性病前瞻性研究"(CKB)浙江省桐乡市数据,剔除基线时自报患有恶性肿瘤、心脏病、脑卒中和糖尿病患者后,纳入分析30-79岁53 916人。采用Cox比例风险模型计算糖尿病发病风险比(HR)。结果 调查对象累计随访391 512人年(平均随访7.26年)。随访期间,男性944人和女性1 643人被新诊断为糖尿病。多因素调整后,与BMI正常组的人群相比,男性超重和肥胖组糖尿病发病的HR值(95%CI)分别为2.72(95%CI:2.47-2.99)和6.27(95%CI:5.33-7.36)。女性超重和肥胖组HR值(95%CI)分别为2.19(95%CI:2.04-2.36)和3.78(95%CI:3.36-4.26);与腰围正常组的人群相比,男性Ⅰ级(85.0-89.9)和Ⅱ级中心性肥胖(≥ 90.0)组糖尿病发病的HR值(95%CI)分别为2.56(2.22-2.95)和4.66(4.14-5.24)。女性Ⅰ级(80.0-84.9)和Ⅱ级中心性肥胖(≥ 85.0)组HR值(95%CI)分别为1.99(1.80-2.21)和3.16(2.90-3.44)。结论 超重/肥胖以及中心性肥胖人群糖尿病发病风险均会升高。在开展控制体重预防糖尿病的同时,更应控制腰围。 | 王浩 胡如英 钱一建 王春梅 谢开婿 陈玲琍 潘东霞 张益丹 卞铮 郭彧 Fiona Bragg 俞敏 李立明 陈铮鸣 | 2018 | 中华流行病学杂志2018，39，6： | 20 |
| 5 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 6 | 重症监护与非重症监护患者的压力性损伤患病率:全州范围的比较显示文摘背景:医院获得性压力性损伤(HAPI)与患病率和病死率的增加有关,被认为在很大程度上是可以预防的。压力性损伤的患病率被视为反映卫生保健质量的一项指标。目的:在全州范围内,比较重症监护室(ICU)患者和非ICU患者的压力性损伤的患病率、严重程度和发生部位。方法 :本研究采用二次数据分析设计,从昆士兰州所有拥有Ⅰ-Ⅲ级重症监护室,并参与了2012-2014年昆士兰床旁审计的卫生医院,提取和分析去识别化处理的压力性损伤数据。样本涵盖所有成人ICU患者和非ICU患者,患者均同意参与昆士兰床旁审计。精神卫生单位除外。结果 :除压力性损伤Ⅰ期外,2012-2014年间,ICU患者HAPI的总患病率为11%,非ICU患者为3%;住院期间,ICU患者发展为压力性损伤的可能性是非ICU患者的3.8倍(RR的95%可信区间为2.7~5.4)。对所有患者来说,骶骨/尾骨都是HAPI最常见的部位(ICU患者为22%,非ICU患者为35%)。然而,ICU患者黏膜压力性损伤的比例(22%)显著高于非ICU患者(2%)。压力性损伤Ⅱ期是HAPI患病率最高的阶段,ICU患者为53%,非ICU患者为63%。 | Fiona Coyer Sandra Miles Sandra Gosley Paul Fulbrook Kirstine Sketcher-Baker Jane-Louise Cook Jacqueline Whitmore | 2017 | 中国护理管理2017，17，9： | 17 |
| 7 | 肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells. | Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone | 2010 | 中华神经外科疾病研究杂志2010，9，1： | 16 |
| 8 | Satellite remote sensing of grasslands:from observation to management显示文摘Aims Grasslands are the world’s most extensive terrestrial ecosystem,and are a major feed source for livestock.Meeting increasing demand for meat and other dairy products in a sustainable manner is a big challenge.At a field scale,Global Positioning System and ground-based sensor technologies provide promising tools for grassland and herd management with high precision.With the growth in availability of spaceborne remote sensing data,it is therefore important to revisit the relevant methods and applications that can exploit this imagery.In this article,we have reviewed the(i)current status of grassland monitoring/observation methods and applications based on satellite remote sensing data,(ii)the technological and methodological developments to retrieve different grassland biophysical parameters and management characteristics(i.e.degradation,grazing intensity)and(iii)identified the key remaining challenges and some new upcoming trends for future development.Important Findings The retrieval of grassland biophysical parameters have evolved in recent years from classical regression analysis to more complex,efficient and robust modeling approaches,driven by satellite data,and are likely to continue to be the most robust method for deriving grassland information,however these require more high quality calibration and validation data.We found that the hypertemporal satellite data are widely used for time series generation,and particularly to overcome cloud contamination issues,but the current low spatial resolution of these instruments precludes their use for field-scale application in many countries.This trend may change with the current rise in launch of satellite constellations,such as RapidEye,Sentinel-2 and even the microsatellites such as those operated by Skybox Imaging.Microwave imagery has not been widely used for grassland applications,and a better understanding of the backscatter behaviour from different phenological stages is needed for more reliable products in cloudy regions.The development of hyperspectral satellite instrumentation and analytical methods will help for more detailed discrimination of habitat types,and the development of tools for greater end-user operation. | Iftikhar Ali Fiona Cawkwell Edward Dwyer Brian Barrett Stuart Green | 2016 | Journal of Plant Ecology2016，9，6： | 15 |
| 9 | Effect of sample size on the response of DEM samples with a realistic grading显示文摘This paper shows that for DEM simulations of triaxial tests using samples with a grading that is representative of a real soil,the sample size significantly influences the observed material response.Four DEM samples with identical initial states were produced:three cylindrical samples bounded by rigid walls and one bounded by a cubical periodic cell.When subjected to triaxial loading,the samples with rigid boundaries were more dilative,stiffer and reached a higher peak stress ratio than the sample enclosed by periodic boundaries.For the rigid-wall samples,dilatancy increased and stiffness decreased with increasing sample size.The periodic sample was effectively homogeneous.The void ratio increased and the contact density decreased close to the rigid walls.This heterogeneity reduced with increasing sample size.The positions of the critical state lines(CSLs) of the overall response in e-log p' space were sensitive to the sample size,although no difference was observed between their slopes.The critical states of the interior regions of the rigid-wall-bounded samples approached that of the homogeneous periodic sample with increasing sample size.The ultimate strength of the material at the critical state is independent of sample size. | Xin Huang Kevin J.Hanley Catherine O'Sullivan Fiona C.Y.Kwok | 2014 | Particuology2014，12，4： | 12 |
| 10 | Current Controversies and the State of the Art in Endovascular Treatment of Vascular Malformations显示文摘Vascular anomalies constitute some of the most difficult diagnostic and therapeutic enigmas that can be encountered in the practice of medicine. The clinical presentations are extremely protean and can range from an asymptomatic birthmark to fulminant。 | Wayne Yakes Alexis Yakes Fiona Rohlffs Krasnodar Ivancev | 2018 | Journal of Interventional Medicine2018，1，2： | 12 |
| 11 | 儿童多导人工耳蜗植入者康复效果影响因素分析显示文摘目的:探讨儿童人工耳蜗植入效果的影响因素及对康复效果的影响,为提高儿童人工耳蜗植入者的康复效果提供参考依据。方法:对76例使用人工耳蜗装置超过1年的儿童患者;使用《儿童人工耳蜗植入者调查问卷》,由经过培训的专业人员与患者及家属通过面对面或电话进行调查。结果:①术前使用过助听器并接受过康复训练时间超过3个月(康复训练组)和未使用过助听器也无康复训练(对照组)的两组患者,在开机后能对环境声音进行识别所需的时间不同,康复训练组患者所需的时间平均为0.9个月,对照组患者为1.9个月,两组差异有显著性(t=2.899,P<0.05)。②6岁以下接受手术(A组)和6岁以上手术(B组)的两组患者,经训练后可以进行基本交流、对话的人数不同,A组为81.4%(35/43),B组为59.3%(16/27),两组差异有显著性(χ2=4.110,P<0.05)。③术前患者及家属的期望值合理(C组)和不合理(D组)的两组患者,术后的满意度存在差异,C组满意率为73.6%(39/53),D组为42.1%(8/19),两组差异有显著性(χ2=6.115,P<0.05)。结论:术后康复效果与术前是否接受过助听器适应训练和康复训练有关;手术年龄越小,术后康复效果越好;术后患者家属的满意度与术前期望值是否合理有关,同时也可影响术后康复效果。 | 孔颖 陈雪清 Fiona Sutherland 王靓 宋妍 李海珍 孟黎晖 刘莎 刘博 莫玲燕 吴燕君 王硕 | 2004 | 中国临床康复2004，8，15： | 10 |
| 12 | Contribution of national bioassessment approaches for assessing ecological water security: an AUSRIVAS case study显示文摘 | Susan J. NICHOLS Fiona J. DYER | 2013 | Frontiers of Environmental Science & Engineering2013，7，5： | 10 |
| 13 | Imaging of bone metastasis: An update显示文摘Early detection of skeletal metastasis is critical for accurate staging and optimal treatment. This paper briefly reviews our current understanding of the biological mechanisms through which tumours metastasise to bone and describes the available imaging methods to diagnose bone metastasis and monitor response to treatment. Among the various imaging modalities currently available for imaging skeletal metastasis, hybrid techniques whichfuse morphological and functional data are the most sensitive and specific, and positron emission tomography(PET)/computed tomography and PET/magnetic resonance imaging will almost certainly continue to evolve and become increasingly important in this regard. | Gerard J O'Sullivan Fiona L Carty Carmel G Cronin | 2015 | World Journal of Radiology2015，7，8： | 10 |
| 14 | 试纸法快速检测工业废水中重金属铜离子显示文摘介绍了一种可以快速、便捷、灵敏地进行现场半定量和定量测定水体中重金属Cu2+浓度的络天青-氨基化纤维素试纸。该试纸的检出限为0.1 mg/L,在pH值为6.0~7.0时,检测的线性范围为0.1~10.0 mg/L,反应时间为120 s。该方法可与微型光谱仪或Cu2+标准比色板联用,可以同时进行定量或者半定量检测。该试纸弥补了显色剂易从试纸上脱落的不足,增强了试纸的稳定性与准确性。该方法可应用于工业废水中Cu2+的测定,与原子吸收分光光度法的测定结果相比较,两者基本一致。 | 李黎 Fiona Regan | 2013 | 工业用水与废水2013，44，5： | 7 |
| 15 | 硒的地球化学与健康显示文摘硒(Se)是天然存在的非金属元素,它是人类和其它动物必需的微量元素,然而过量硒有毒。在所有元素中,硒的安全范围最窄,每日硒摄入量〈40μg会引起硒的饮食不足,但当每日摄入量〉400μg时又会产生毒性,因此需要严格控制人体和其它动物对硒的摄入量,理解硒的环境暴露水平与健康间的关系具有重要意义。地质学基本控制了土壤中硒的浓度, | Fiona Fordyce 周群芳(译) | 2007 | AMBIO-人类环境杂志2007，36，1： | 7 |
| 16 | Post-operative strabismus control and motor alignment for basic intermittent exotropia显示文摘AIM:To assess strabismus control and motor ocular alignment for basic exotropia surgery at 5y follow-up.METHODS:The medical records of 80 consecutive patients aged less than 17 years of age,who underwent surgery for basic exotropia by a single surgeon between years 2000 to 2009 and completed a minimum of 5y follow-up post-operatively were reviewed.Pre- and post-operative characteristics were documented at 1wk,6mo,1,3 and 5y follow-up.Subjects at 5-year follow-up were assigned to the success group if they had a postoperative angle of deviation within 10 prism diopters of exotropia or within 5 prism diopters of esotropia for distance on prism cover test,and had moderate to good strabismus control.The remaining subjects were assigned to the failure group.RESULTS:Post-operative surgical success at one week was 75%,which decreased to 41% at 5y follow-up.The success group was noted to have more patching pre-operatively(P=0.003).The duration of patching a day(P=0.020) and total duration of patching preoperatively(P=0.030) was higher in the success group.Surgical success at 1y(P=0.004) and 3y(P=0.002) were associated with higher surgical success at 5y follow-up.CONCLUSION:Post-operative motor alignment and strabismus control for basic exotropia surgery at 1y and beyond is associated with higher exotropia surgery success at 5-year follow-up.There is an association between pre-operative patching and 5-year surgical success of basic intermittent exotropia surgery. | Fiona Chew Lee Min Bhambi Uellyn Gesite-de Leon Boon Long Quah | 2016 | International Journal of Ophthalmology(English edition)2016，9，7： | 7 |
| 17 | Implementation of a Pediatric Emergency Triage System in Xiamen, China显示文摘 | Gang-Xi Lin Yin-Ling Yang Denise Kudirka Colleen Church Collin K K Yong Fiona Reilly Qi-Yi Zeng | 2016 | Chinese Medical Journal2016，，20： | 7 |
| 18 | 中国成人糖尿病、血糖与结直肠癌发病率:针对50万人的前瞻性研究显示文摘背景糖尿病可致结直肠癌(CRC)的发病风险升高。糖尿病病程和非糖尿病患者的血糖与CRC发病风险之间的相关性仍不清楚。方法2004至2008年前瞻性中国Kadoofe Biobank研究从10个不同地区纳入了512 713名受试者。在10年随访期间,在基线无癌症史的510 136名受试者中共记录有3 024例新发CRC病例(1 745例结肠癌,1 716例直肠癌)。应用Cox回归分析对糖尿病(入组前诊断或筛查发现的)或无糖尿病病史者随机血糖(RPG)水平与CRC发病相关性的校正风险比(HR)进行估计。结果基线时,共有5.8%的受试者患有糖尿病。糖尿病患者发生CRC的校正HR为1.18(95%可信区间1.04~1.33),且发生结肠癌与直肠癌的风险相当[1.19(1.01~1.39)比1.14(0.96~1135)]。这些患者发生CRC的HR随糖尿病病程的延长而下降(趋势P值为0.03)。在入组前无糖尿病的受试者中,其RPG水平与CRC发病呈正相关,基线RPG每升高1 mmol/L其发生CRC的校正HR为1.04(1.02~1.05),且发生结肠癌与直肠癌的风险亦相当[1.03(1.01~1.05)比1.04(1.02~1.06)]。在男性中,糖尿病和RPG与CRC发病风险的相关性高于女性,但其差异无统计学意义(异质性检验的P值分别为0.3和0.2)。讨论在中国成年人中,未诊断糖尿病者其糖尿病和升高的血糖水平与CRC发病风险升高相关。 | Yuanjie Pang Christiana Kartsonak yu Guo Yiping Chen Ling Yang Zheng Bian Fiona Bragg Iona Y Millwood Leijia Shen Songgen Zhou Jiben Liu Junshi Chen Liming Li Michael V Holmes Zhengming Ghen 霍永丰(译) | 2019 | 英国医学杂志中文版2019，22，1： | 6 |
| 19 | 新工科共核知识驱动的ESP课程体系研究显示文摘工程人才人文素养、语言竞争力和专业胜任力的提振是新工科教育面临的时代命题。基于ESP共核特征和'广角+窄角'课程理念,研究首先明晰了ESP课程定位:在多重动态需求下聚焦共核语言素养,并把它转换为语言竞争力和专业胜任力。其次构建了知识、素养、能力及方向四维课程模型,并以此为基础设计了车辆类专业'1+3+N'共核ESP课程体系。借助定量及质性研究表明:实验班的课程设置、实施、背景与课程效果之间均高度正相关(Pearson r>0.70,p<0.01),其中课程效果与对照班具有显著性差异(p<0.01)。课程体系有助于新工科的人文传承和工程人才语言竞争力的提升,可以满足'行业+方向'的新工科大类培养目标。研究将为理工院校和其他高校大类学科ESP改革提供借鉴范式。 | 杨成 Fiona Henderson | 2020 | 高等工程教育研究2020，68，4： | 5 |
| 20 | The impact of teacher written feedback on individual writers显示文摘 | Fiona Hyland | 1998 | Journal of Second Language Writing1998，，3： | 4 |
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