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| 1 | Normal liver stiffness: a study in living donors with normal liver histology显示文摘AIM: To define the normal range of liver stiffness(LS) values using transient elastography in living-related liver transplantation candidate donors with normal liver histology. METHODS: LS was measured using Fibroscan in 50(16 women, 34 men) healthy potential donors(mean age 28.4 ± 5.9 years) who were being evaluated for liver donation for their relatives at the National Liver Institute, Menoufeya University, Egypt. All potential donors had normal liver tests and were negative for hepatitis B or C virus infection. Abdominal ultrasounds showed normal findings. None of the subjects had diabetes, hypertension, renal impairment, heart disease, or body mass index > 30 kg/m2. All subjects had normal liver histology upon liver biopsy. They all donated the right lobe of their liver with successful outcomes.RESULTS: The mean LS was 4.3 ± 1.2 k Pa(range: 1.8-7.1 k Pa). The 5th and 95 th percentiles of normal LS were 2.6 k Pa and 6.8 k Pa, respectively, with a median of 4 k Pa; the interquartile range was 0.6 ± 0.4. LS measurements were not significantly different between men and women(4.4 ± 1.1 k Pa vs 3.9 ± 1.3 k Pa) and did not correlate with age. However, stiffness values were significantly lower in subjects with a body mass index < 26 kg/m2 compared to those with an index ≥ 26 kg/m2(4.0 ± 1.1 k Pa vs 4.6 ± 1.2 k Pa; P <0.05). There were no differences in hospital stay or postoperative bilirubin, albumin,alanine and aspartate transaminases, or creatinine levels(at discharge) between donors with livers stiffness ≤ 4 k Pa and those with stiffness > 4 k Pa. CONCLUSION: Healthy donors with normal liver histology have a median LS of 4 k Pa. Stiffness values are elevated relative to increase in body mass index. | Ayman Alsebaey Naglaa Allam Khalid Alswat Imam Waked | 2015 | World Journal of Hepatology2015，7，8： | 3 |
| 2 | Clinical epidemiology of ulcerative colitis in Arabs based on the Montréal classification显示文摘AIM:To determine the clinical,epidemiological and phenotypic characteristics of ulcerative colitis(UC)in Saudi Arabia by studying the largest cohort of Arab UC patients.METHODS:Data from UC patients attending gastroenterology clinics in four tertiary care centers in three cities between September 2009 and September 2013were entered into a validated web-based registry,inflammatory bowel disease information system(IBDIS).The IBDIS database covers numerous aspects of inflammatory bowel disease.Patient characteristics,disease phenotype and behavior,age at diagnosis,course of the disease,and extraintestinal manifestations were recorded.RESULTS:Among 394 UC patients,males comprised51.0%and females 49.0%.According to the Montréal classification of age,the major chunk of our patients belonged to the A2 category for age of diagnosis at17-40 years(68.4%),while 24.2%belonged to the A3category for age of diagnosis at>40 years.According to the same classification,a majority of patients had extensive UC(42.7%),35.3%had left-sided colitis and29.2%had only proctitis.Moreover,51.3%were in remission,16.6%had mild UC,23.4%had moderate UC and 8.6%had severe UC.Frequent relapse occurred in17.4%patients,infrequent relapse in 77%and 4.8%had chronic disease.A majority(85.2%)of patients was steroid responsive.With regard to extraintestinal manifestations,arthritis was present in 16.4%,osteopenia in 31.4%,osteoporosis in 17.1%and cutaneous involvement in 7.0%.CONCLUSION:The majority of UC cases were young people(17-40 years),with a male preponderance.While the disease course was found to be similar to that reported in Western countries,more similarities were found with Asian countries with regards to the extent of the disease and response to steroid therapy. | Othman R Alharbi Nahla A Azzam Ahmed S Almalki Majid A Almadi Khalid A Alswat Nazia Sadaf Abdulrahman M Aljebreen | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 3 | Assessment of Alpha-Fetoprotein in the Diagnosis of Hepatocellular Carcinoma in Middle Eastern Patients显示文摘 | Faisal M. Sanai Samia Sobki Khalid I. Bzeizi Shaffi A. Shaikh Khalid Alswat Waleed Al-Hamoudi Majid Almadi Faisal Al Saif Ayman A. Abdo | 2010 | Digestive Diseases and Sciences2010，，12： | 2 |
| 4 | The role of endocannabinoids system in fatty liv- er disease and therapeutic potentials 显示文摘 | Alswat KA | 2013 | Saudi J Gastroen- terol2013，19，4： | 1 |
| 5 | New insights into autoimmune liver diseases显示文摘 | Teru Kumagi Khalid Alswat Gideon M. Hirschfield Jenny Heathcote | 2008 | Hepatology Research2008，，8： | 1 |
| 6 | Genome-wide association study of chronic hepatitis B virus infection reveals a novel candidate risk allele on 11q22.3显示文摘 | Ahmed Al-Qahtani Hanif G Khalak Fowzan S Alkuraya Waleed Al-hamoudy Khalid Alswat Mohammed A Al Balwi Ibrahim Al AbdulKareem Faisal M Sanai Ayman A Abdo | 2013 | Journal of Medical Genetics2013，，11： | 1 |
| 7 | Genetic variation at ?1878 (rs2596542) in MICA gene region is associated with chronic hepatitis B virus infection in Saudi Arabian patients显示文摘 | Ahmed A. Al-Qahtani Mashael Al-Anazi Ayman A. Abdo Faisal M. Sanai Waleed Al-Hamoudi Khalid A. Alswat Hamad I. Al-Ashgar Nisreen Khalaf Nisha Viswan Mohammed N. Al-Ahdal | 2013 | Experimental and Molecular Pathology2013，，3： | 1 |
| 8 | Appropriateness and diagnostic yield of upper gastrointestinal endoscopy in an open-access endoscopy system显示文摘 | Abdulrahman Aljebreen Khalid Alswat Majid Almadi | 2013 | Saudi Journal of Gastroenterology2013，，5： | 1 |
| 9 | Genetic variation in interleukin 28B and correlation with chronic hepatitis B virus infection in Saudi Arabian patients显示文摘 | Ahmed A. Al‐Qahtani Mashael R. Al‐Anazi Ayman A. Abdo Faisal M. Sanai Waleed K. Al‐Hamoudi Khalid A. Alswat Hamad I. Al‐Ashgar Nisreen Z. Khalaf Nisha A. Viswan Mohammed N. Al Ahdal | 2014 | Liver Int2014，，7： | 1 |
| 10 | Assessment of Alpha-Fetoprotein in the Diagnosis of Hepatocellular Carcinoma in Middle Eastern Patients显示文摘 | Faisal M. Sanai Samia Sobki Khalid I. Bzeizi Shaffi A. Shaikh Khalid Alswat Waleed Al-Hamoudi Majid Almadi Faisal Al Saif Ayman A. Abdo | 2010 | Digestive Diseases and Sciences2010，，12： | 1 |
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