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| 1 | Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress显示文摘AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors. | Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira | 2017 | World Journal of Gastroenterology2017，23，28： | 6 |
| 2 | Membrane redistributions through multi-intercellular exchanges and serial trogocytosis显示文摘Trogocytosis 是在膜的房间之间的快速的转移并且联系蛋白质。Trogocytic 交换在不同房间类型之间被调查了,主要在二房间的系统,包含一个施主和一种领受人房间类型。这里,我们在一个更复杂的系统学习了 trogocytosis,包含不仅几个有免疫力的房间子集而且多重肿瘤房间。我们证明 CD4+ T 房间, CD8+ T 房间和单核白血球能获得膜补丁和他们由多重同时的 trogocytoses 从不同肿瘤房间包含的未经触动的蛋白质。CD4+ 和 CD8+ T 房间的 trogocytic 能力被发现类似于自体同源的单核白血球的,却劣等。激活的外部血的 mononuclear 房间(PBMC ) 可以也在一个所有自体同源的系统交换在自己之间的膜。为这个原因,单核白血球能够从多重肿瘤房间来源获得膜,并且再把他们转移到自体同源的 T 房间,与一些他们的自己的膜(连续 trogocytosis ) 一起。我们的数据说明在自体同源的激活的有免疫力的受动器房间和他们的环境之间的膜交换的程度,并且包括鈥渂y stander 鈥 ? 房间,本地环境的细胞的内容怎么可以影响有免疫力的受动器房间的功能。 | Estlbahz Alegre Klave-Yune HoWangYin Benolt Favier Jeremy Baudhuin Emilie Lesport Marina Daouya Alvaro Gonzalez Edgardo D Carosella Joel LeMaoult | 2010 | Cell Research2010，20，11： | 2 |
| 3 | Pathophysiologieal role and therapeutic implications of inflammation in dia- betic nephropathy显示文摘 | Luis-Rodriguez D Martinez-Castelao A Gorriz J L De- Alvaro F Navarro-Gonzalez J F | 2012 | World J Diabetes2012，3，： | 1 |
| 4 | Ectopic expression of a mutant form of PKC alpha originally found in human tumors: aberrant subcellular translocation and effects on growth control显示文摘 | Alvaro V Prevostel C Joubert D | 1997 | Oncogene1997，14，： | 1 |
| 5 | Novel domino reactions in β-carbolines with triple bonded dienophiles显示文摘 | Alvaro G G Gema D Ulises A | 2008 | Tetrahedron Lett2008，49，38： | 1 |
| 6 | ABCC8 and ABCC9: ABC transporters that regulate K+ channels显示文摘 | Joseph Bryan Alvaro Mu?oz Xinna Zhang Martina Düfer Gisela Drews Peter Krippeit-Drews Lydia Aguilar-Bryan | 2007 | Pflügers Archiv - European Journal of Physiology2007，，5： | 1 |
| 7 | 显示文摘 | Baleizao C Das D | 2004 | J Catal2004，228，1： | 1 |
| 8 | Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism显示文摘 | Gaudio E Barbaro B Alvaro D | 2006 | Gastroenterology2006，130，4： | 1 |
| 9 | Optimal Operation of a Pumped-storage Hydro Plant that Compensates the Imbalances of a Wind Power Producer 显示文摘 | Alvaro Jaramillo Duque Castronuovo E D Shnchez I | 2011 | Electric Power Systems Research2011，81，9： | 1 |
| 10 | Cholangiocarcinoma:risk factors and clinical presentation 显示文摘 | Gatto M Alvaro D | 2010 | Eur Rev Med Pharmacol Sci2010，14，4： | 1 |
| 11 | In vivo identification of an HLA ‐ G complex as ubiquitinated protein circulating in exosomes显示文摘 | Estibaliz Alegre Vera Rebmann Joel LeMaoult Carmen Rodriguez Peter A. Horn Angel Díaz‐Lagares José I. Echeveste Alvaro González | 2013 | Eur J Immunol2013，，7： | 1 |
| 12 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 13 | Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial显示文摘 | Shamir R Mehta Jean-Francois Tanguay John W Eikelboom Sanjit S Jolly Campbell D Joyner Christopher B Granger David P Faxon Hans-Jurgen Rupprecht Andrzej Budaj Alvaro Avezum Petr Widimsky Philippe Gabriel Steg Jean-Pierre Bassand Gilles Montalescot Carlos | 2010 | The Lancet2010，，9748： | 1 |
| 14 | Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial显示文摘 | Shamir R Mehta Jean-Francois Tanguay John W Eikelboom Sanjit S Jolly Campbell D Joyner Christopher B Granger David P Faxon Hans-Jurgen Rupprecht Andrzej Budaj Alvaro Avezum Petr Widimsky Philippe Gabriel Steg Jean-Pierre Bassand Gilles Montalescot Carlos | 2010 | The Lancet2010，，9748： | 1 |
| 15 | Variants of the BMP15 gene in a cohort of patients with premature ovarian failure 显示文摘 | Tiotiu D Alvaro MB Imbert R | 2010 | Hum R eprod2010，25，： | 1 |
| 16 | Differential patterns of lipid-protein association in fast and slow cholesterol nucleating human gallbladder biles: implications for cholesterol nucleation from biliary lipid carriers显示文摘 | Corradini SG Alvaro D Giacomelli L | 1991 | Biochim Biophys Acta1991，1086，1： | 1 |
| 17 | Serum and billary in- sulin-like growth factor I and vascular endothelial growth factor in determining the cause of obstructive cholestasis 显示文摘 | Alvaro D Macarri G Mancino MG | 2007 | Ann Intern Med2007，147，7： | 1 |
| 18 | The Major Surface Carbohydrates of the Echinococcus granufosus Cyst : Mucin - Type O - Glycans Decorated by Novel Galactose - Based Structures显示文摘 | Alvaro D E Carolina Fontana Adriane R Todeschini | 2009 | Biochemistry2009，48，11： | 1 |
| 19 | Estrogens stimulate prohferation of intrahepatic bihary epithelium in rats 显示文摘 | Alvaro D Alpini G Onori P | 2000 | Gastroenterology2000，119，6： | 1 |
| 20 | Variants of the BMP15 gene in a cohort of patients with premature ovarian failure显示文摘 | Tiotiu D Alvaro Mercadal B Imbert R | 2010 | Hum Reprod2010，25，6： | 1 |
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