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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Neural EGF-like protein 1(NELL-1):Signaling crosstalk in mesenchymal stem cells and applications in regenerative medicine显示文摘Bone tissue regeneration holds the potential to solve both osteoporosis and large skeletal defects,two problems associated with significant morbidity.The differentiation of mesenchymal stem cells into the osteogenic lineage requires a specific microenvironment and certain osteogenic growth factors.Neural EGF Like-Like molecule 1(NELL-1)is a secreted glycoprotein that has proven,both in vitro and in vivo,to be a potent osteo-inductive factor.Furthermore,it has been shown to repress adipogenic differentiation and inflammation.NELL-1 can work synergistically with other osteogenic factors such as Bone Morphogenic Protein(BMP)2 and9,and has shown promise for use in tissue engineering and as a systemically administered drug for the treatment of osteoporosis.Here we provide a comprehensive up-to-date review on the molecular signaling cascade of NELL-1 in mesenchymal stem cells and potential applications in bone regenerative engineering. | Mikhail Pakvasa Alex Alverdy Sami Mostafa Eric Wang Lucy Fu Alexander Li Leonardo Oliveira Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Tong-Chuan He Guillermo A.Ameer Russell R.Reid | 2017 | Genes & Diseases2017，4，3： | 13 |
| 3 | Gastroesophageal reflux disease and severe obesity:Fundoplication or bariatric surgery?显示文摘Increases in the prevalence of obesity and gastroesophageal reflux disease (GERD) have paralleled one another over the past decade, which suggests the possibility of a linkage between these two processes. In both instances, surgical therapy is recognized as the most effective treatment for severe, refractory disease. Current surgical therapies for severe obesity include (in descending frequency) Roux-en-Y gastric bypass, adjustable gastric banding, sleeve gastrectomy, and biliopancreatic diversion with duodenal switch, while fundoplication remains the mainstay for the treatment of severe GERD. In several large series, however, the outcomes and durability of fundoplication in the setting of severe obesity are not as good as those in patients who are not severely obese. As such, bariatric surgery has been suggested as a potential alternative treatment for these patients. This article reviews current concepts in the putative pathophysiological mechanisms by which obesity contributes to gastroesophageal reflux and their implications with regards to surgical therapy for GERD in the setting of severe obesity. | Vivek N Prachand John C Alverdy | 2010 | World Journal of Gastroenterology2010，16，30： | 10 |
| 4 | Protective effects of high-molecular weight Polyethylene Glycol (PEG) in human lung endothelial cell barrier regulation: Role of actin cytoskeletal rearrangement显示文摘 | Eddie T. Chiang Sara M. Camp Steven M. Dudek Mary E. Brown Peter V. Usatyuk Olga Zaborina John C. Alverdy Joe G.N. Garcia | 2008 | Microvascular Research2008，，2： | 2 |
| 5 | Total parenteral nutrition promotes bacterial translocation from the gut显示文摘 | Alverdy JC Aoy SE Moss GS | 1988 | Surgery1988，104，2： | 1 |
| 6 | The effect of glutamine-enrich TPN on gut immune cellularity显示文摘 | Alverdy JC Aoys E Carrington PW | 1992 | J Surg Res1992，52，： | 1 |
| 7 | Glutamine supplemented total parenteral nutrition improves gut immune function显示文摘 | Bruke D Alverdy J C Aoya E | 1989 | Arch Surg1989，124，： | 1 |
| 8 | Glutamine supplemented total parenteral nutrition improves gut immune function显示文摘 | Bruke D Alverdy J C Aoys G S M | | 0，，： | 1 |
| 9 | Laparoscopic intracavitary debridement of peripancreatic necrosis:preliminary report and description of the technique显示文摘 | Alverdy J Vargish T Desai T | 2000 | Surgery2000，127，1： | 1 |
| 10 | The re-emerging role of the intestinal microflora in critical illness and inflammation:why the gut hypothesis of sepsis syndrome will not go away显示文摘 | Alverdy J C Chang E B | 2008 | J Leukoc Biol2008，83，3： | 1 |
| 11 | The effect of glutamine- enriched TPN on gut immune cellularity显示文摘 | Alverdy Ja Aoys E Weiss - Garrington P | 1992 | J Surg Res1992，52，： | 1 |
| 12 | Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha显示文摘 | BERGQVIST S ALVERDI V MENGEL B | 2009 | Proc Natl Acad Sci USA2009，106，19： | 1 |
| 13 | Duodenal Switch Provides Superior Resolution of Metabolic Comorbidities Independent of Weight Loss in the Super-obese (BMI?≥?50?kg/m2) Compared with Gastric Bypass显示文摘 | Vivek N. Prachand Marc Ward John C. Alverdy | 2010 | Journal of Gastrointestinal Surgery2010，，2： | 1 |
| 14 | Glutamine supplemented total parenteral nutrition improves gut immune function 显示文摘 | Bruke D Alverdy JC Aoya E | 1989 | Arch Surg1989，124，： | 1 |
| 15 | Influence of the critically ill state on host-pathogen interactions within the intestine:Gut-derived sepsis redefined显示文摘 | Alverdy JC Laughlin RS Wu L | 2003 | Grit Care Meal2003，31，2： | 1 |
| 16 | The effect of glutamine-enriched TPN on gut immune cellularity显示文摘 | Alverdy JA Aoys E Weiss-Carrington P | 1992 | J Surg Res1992，52，1： | 1 |
| 17 | Differential steady- state tyrosine phosphorylation of two oligomeric forms of mitochon-drial FOF1ATPsynthase: a structural proteomic analysis 显示文摘 | Di Pancrazio F Bisetto E Alverdi V | 2006 | Proteomics2006，6，3： | 1 |
| 18 | The impact of stress and nutrition on bacterial host interactions at the intestinal ep ithelial surface显示文摘 | Alverdy J Zaborina O Wu L | 2005 | Curr Opin Clin Nutr Metab Care2005，8，2： | 1 |
| 19 | Glutamine supplemented total parenteral nutrition improves gut im-mune function显示文摘 | Bruke D Alverdy J C Aoys G S M | 1989 | Arch Surg1989，，124： | 1 |
| 20 | Glutamine-supplemented total parenteral nutrition improves gut immune function显示文摘 | Burke D J Alverdy J C Aoys E | 1989 | Arch Surg1989，124，12： | 1 |
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