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| 1 | Concepts of oxidative stress and antioxidant defense in Crohn's disease显示文摘Oxygen free radical and lipid peroxides(oxidative stress)are highly reactive and represent very damaging compounds.Oxidative stress could be a major contributing factor to the tissue injury and fibrosis that characterize Crohn’s disease.An imbalance between increased reactive oxygen species levels and decreased antioxidant defenses occurs in Crohn’s patients.Decreased blood levels of vitamins C and E and decreased intestinal mucosal levels of CuZn superoxide dismutase,glutathione,vitamin A,C,E,andβ-carotene have been reported for Crohn’s patients.Increased levels of proinflammatory cytokines,such as interleukin-1 and-8 and tumor necrosis factor,have been detected in inflammatory bowel disease.Oxidative stress significantly increased the production of neutrophils,chemokines,and interleukin-8.These effects were inhibited by antioxidant vitamins and arachidonic acid metabolite inhibitors in human intestinal smooth muscle cells isolated from the bowels of Crohn’s disease patients.The main pathological feature of Crohn’s disease is an infiltration of polymorphonuclear neutrophils and mononuclear cells into the affected part of the intestine.Activated neutrophils produce noxious substances that cause inflammation and tissue injury.Due to the physiological and biochemical actions of reactive oxygen species and lipid peroxides,many of the clinical and pathophysiological features of Crohn’s disease might be explained by an imbalance of increased reactive oxygen species and a net decrease of antioxidant molecules.This review describes the general concepts of free radical,lipid peroxide and antioxidant activities and eventually illustrates their interferences in the development of Crohn’s strictures. | Mohammed A Alzoghaibi | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | Circulatory neutrophil chemokines in statin-treated diabetic patients显示文摘 | Alfadda AA Alzoghaibi MA | | 0，，04： | 1 |
| 3 | Circulatory neutrophil chemokines in sta- tin-treated diabetic patients显示文摘 | Alfadda AA Alzoghaibi MA | 2008 | Saudi Med J2008，29，4： | 1 |
| 4 | Relationship of the Ara- bic version of the asthma control test with ventilatory function tests and levels of exhaled nitric oxide in adult asthmatics显示文摘 | Habib SS Alzoghaibi MA Abba AA | 2014 | Saudi Med J2014，35，4： | 1 |
| 5 | Lipid peroxides, superoxide dismutase and circulating IL-8 and GCP-2 in patients with severe obstructive sleep apnea: a pilot study显示文摘 | Mohammed A. Alzoghaibi Ahmed S. O. BaHammam | 2005 | Sleep and Breathing2005，，3： | 1 |
| 6 | Linoleic acid, but not oleic acid, upregulates the production of interleukin-8 by human intestinal smooth muscle cells isolated from patients with Crohn’s disease显示文摘 | M.A Alzoghaibi S.W Walsh A Willey A.A Fowler Iii M.F Graham | 2003 | Clinical Nutrition2003，，6： | 1 |
| 7 | Circulatory neutrophil chemokines in statin-treated diabetic patients显示文摘 | Alfadda AA Alzoghaibi MA | 2008 | Saudi Med J2008，29，4： | 1 |
| 8 | Lipid peroxides, superoxide dis- mutase and circulating IL-8 and GCP-2 in patients with severe ob- structive sleep apnca: a pilot study 显示文摘 | Alzoghaibi MA Bahammam AS | 2005 | Sleep Breath2005，9，3： | 1 |
| 9 | Lipid peroxides, superoxide dismutase and circulating IL -8 and GCP- 2 in patients with severe obstructive sleep apnea:a pilot study显示文摘 | Alzoghaibi MA Bahammam AS | 2005 | Sleep Breath2005，9，3： | 1 |
| 10 | Exhaled nitric oxide in stable chronic obstructive pulmonary disease显示文摘 | Beg M F Alzoghaibi M A Abba A A | 2009 | Ann Thorac Med2009，4，2： | 1 |
| 11 | Circulatory neutrophil chemokines in statin-treated diabetic patients 显示文摘 | Alfadda AA Alzoghaibi MA | 2008 | Saudi Ned J2008，29，4： | 1 |
| 12 | Relationship of the Arabicversion of the asthma control test with ventilatory function tests andlevels of exhaled nitric oxide in adult asthmatics 显示文摘 | Habib SS Alzoghaibi MA Abba AA | 2014 | Saudi Med J2014，35，4： | 1 |
| 13 | Circulatory neutrophil chemokines in statin-treated diabetic patients 显示文摘 | Alfadda AA Alzoghaibi MA | 2008 | Saudi Med J2008，29，4： | 1 |
| 14 | Exhaled nitric oxide in stable chronic obstructive pulmonary disease 显示文摘 | Beg MFS Alzoghaibi MA Abba AA | 2009 | Ann Thorac Med2009，4，2： | 1 |
| 15 | Circulatory neutrophil chemokines in sta- tin-treated diabetic patients 显示文摘 | Alfadda AA Alzoghaibi MA | 2008 | Saudi Med J2008，29，4： | 1 |
| 16 | Exhaled nitric oxide in stable chronic obstructive pulmonary disease 显示文摘 | Beg MF Alzoghaibi MA Abba AA | 2009 | Ann Thorac Med2009，4，2： | 1 |
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